Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.8.1.4 (diaphorase)
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Human Gene/Protein
CGI-49 13.5
diaphorase 13.5
lipoamide dehydrogenase 13.3
solute carrier family 25 member 19 12.5
Myosin light chain 3 12.5
SH3 domain-binding glutamic acid-rich-like protein 3 12.5
complement Factor H-related protein 1 12.5
lipoamide 12.2
Diaphorase 12.1
troponin I type 3 11.9
DLDH 11.9
dihydrolipoamide acetyltransferase 11.7
lipoic acid-containing protein 11.5
70kD) 11.5
DRC2 11.2
dihydrolipoamide succinyltransferase 11.1
E3BP 11.0
pdhB 11.0
KGDHC 11.0
Glycine synthase 10.9
lat1 10.9
tubulin alpha-1 chain 10.7
neuronal tropomodulin 10.7
Nucleoside diphosphokinase 10.7
GIN1 10.7
NADH2 10.7
DIA1 10.6
neurofilament triplet L protein 10.5
NADH diaphorase 10.4
GluR4c 10.3
protein inhibitor of neuronal nitric oxide synthase 10.3
STARD6 10.2
DRS1 10.2
aflatoxin B1-aldehyde reductase 10.2
Lipoyltransferase 10.2
2-oxoglutarate dehydrogenase 10.2
pyruvate dehydrogenase complex 10.1
cvHSP 10.0
iron-sulfur protein 3 10.0
CHED 10.0
LC8a 10.0
IMMT 10.0
LIPT1 10.0
alpha-ketoglutarate dehydrogenase 10.0
NADPH2 9.9
BCKDH 9.9
DHTKD1 9.9
E2k 9.8
fructose-bisphosphate aldolase C 9.8
ASAL 9.8
Argininosuccinate synthetase 9.7
succinate dehydrogenase flavoprotein subunit 9.7
alpha 1 collagen 9.6
Malic dehydrogenase 9.6
PDHA 9.5
PDHB 9.5
E1 alpha 9.4
aconitase 2 9.4
MTND1 9.4
H-protein 9.4
NMO1 9.3
Chloride intracellular channel protein 1 9.2
Pyruvate dehydrogenase 9.2
pyruvate dehydrogenase 9.2
BOLA3 9.2
REM1 9.2
PDHC 9.1
mu-crystallin 9.1
PRMT9 9.0
glycine decarboxylase 9.0
UDP-glucuronic acid decarboxylase 9.0
Succinic dehydrogenase 8.9
septin 2 8.9
FADH2 8.9
steroid dehydrogenase-like protein 8.9
MAPK4 8.9
NADH-coenzyme Q reductase 8.9
QR1 8.9
ADCY8 8.9
protein X 8.8
Signal transducer and activator of transcription 4 8.8
flavin reductase 8.7
ALDH9 8.7
DNASE1L3 8.7
S3-12 8.6
gcv 8.6
E3 protein 8.6
glycine dehydrogenase 8.6
flavoprotein 8.6
FAD synthetase 8.6
ATP binding protein 8.5
FAD 8.5
stumpy 8.4
plastin 3 8.4
PEP3 8.4
PRMT8 8.4
PRMT2 8.3
DTD 8.3
NADH 8.3
coronin-1 8.3
PSPH 8.3
lipoyltransferase 8.3
putative serine/threonine protein kinase 8.3
putative oxidoreductase 8.3
3alpha-HSD 8.2
MINOR 8.2
DLST 8.2
AKAP4 8.2
PKG1 8.2
CYB5R3 8.2
neuronal nitric oxide synthase 8.1
NQO1 protein 8.1
CKMT1 8.1
transacylase 8.1
LPD 8.0
DCIP 8.0
Microtubule-associated protein 1A 8.0
ISP2 8.0
NADPH 8.0
MT-ND2 8.0
GLRX5 8.0
VK3 8.0
electron transfer flavoprotein-ubiquinone oxidoreductase 8.0
PRMT3 8.0
Bactericidal/permeability-increasing protein 8.0
PDHA1 8.0
D-lactate dehydrogenase 7.9
P78 7.9
NFU1 7.9
SETA 7.9
NADP+ 7.9
ACO2 7.9
EF-Ts 7.8
BCKD kinase 7.8
PSAT1 7.8
DIA 7.8
B4GALT1 7.8
quinolinate phosphoribosyltransferase 7.7
DT-diaphorase 7.7
nitric oxide synthase 7.7
LRG-47 7.7
NBL 7.7
quinone reductase 7.7
peroxiredoxin 4 7.7
NAD+ 7.7
isocitric dehydrogenase 7.7
sarcosine dehydrogenase 7.7
58kDa 7.7
TFEC 7.7
COX17 7.6
aconitate hydratase 7.6
cyclophilin 40 7.6
GPD 7.6
EHD2 7.6
proteasome subunit alpha 7.6
Cyclin A1 7.5
glutamate dehydrogenase 1 7.5
LDH-B 7.5
NDUFV1 7.5
HDH 7.5
more...
Disease
Phosphoenolpyruvate carboxykinase deficiency 13.5
Lipoamide dehydrogenase deficiency 11.5
CHED 9.9
PDH deficiency 9.0
vitamin B deficiency 9.0
Lissauer 8.4
Bordetella infection 8.4
Persistent pulmonary hypertension 8.1
DTD 8.0
Reflux nephropathy 8.0
DIA 7.8
CGD 7.3
Ileum 7.3
ANM 7.3
erythrasma 7.2
stage I breast cancer 7.1
cardiosclerosis 6.9
Microangiopathy 6.9
CBS deficiency 6.8
Klebs 6.7
Chronic progressive external ophthalmoplegia 6.7
glutaric aciduria 6.6
favism 6.5
Friedreich's ataxia 6.5
hyperglycinemia 6.3
keratocyst 6.3
SGS 6.3
Retinal ischemia 6.3
lymphoblastoma 6.2
PDC 6.2
methemoglobinemia 6.2
alcoholic cardiomyopathy 6.1
PC deficiency 6.1
Spinal cord ischemia 6.1
Reye 6.1
Lip 6.1
SGS 5.9
Choroid 5.9
Choroid 5.9
PAPA 5.8
Leigh syndrome 5.8
GCE 5.8
Gull 5.8
propionic acidemia 5.7
diabetic hyperglycemia 5.6
acrocyanosis 5.6
liver infection 5.6
Rotor 5.6
maple syrup urine disease 5.6
Enzyme inhibition 5.5
GHD 5.5
lactic acidosis 5.5
Bardet-Biedl syndrome 5.4
centronuclear myopathy 5.3
testicular dysfunction 5.3
audiogenic seizure 5.2
Copper deficiency 5.2
myeloblastosis 5.1
LAD 5.1
HTL 5.0
spindle cell sarcoma 5.0
chronic rhinitis 5.0
SD1 5.0
farmer's lung 5.0
cerebral thrombosis 4.9
NAME 4.9
PHS 4.9
nutritional disorder 4.9
galactosemia 4.8
anal atresia 4.8
chronic granulomatous disease 4.7
enzyme deficiency 4.7
Infestation 4.6
clonorchiasis 4.6
MELAS 4.6
mastopathy 4.6
neonatal asphyxia 4.5
Diaphragm 4.5
PCC 4.4
mitochondrial myopathy 4.4
MVA 4.3
MELAS 4.3
bovine leukemia 4.3
HYP 4.2
MCD 4.2
thiamine deficiency 4.2
varices 4.2
pulpitis 4.2
uvea 4.2
NBS 4.2
Kearns-Sayre syndrome 4.2
abnormal involuntary movements 4.2
moderate mental retardation 4.2
Hymenolepis 4.1
methylmalonic acidemia 4.1
cauda equina syndrome 4.1
myoclonus epilepsy 4.0
HEP 4.0
Huntington's disease 4.0
Fallopian tube 4.0
lipidosis 3.9
L. infantum 3.9
Goldstein 3.9
PMS 3.9
CLN3 3.8
AMN 3.8
Benson 3.8
Chagas 3.8
parakeratosis 3.8
antidiuresis 3.7
MDI 3.7
renal hypertension 3.7
Leber's hereditary optic neuropathy 3.6
leukodystrophy 3.6
homocystinuria 3.6
Tongue 3.6
Dissociation 3.6
Rosenthal 3.6
Aujeszky's disease 3.5
Phenylketonuria 3.5
EDA 3.5
cataplexy 3.5
phenylketonuria 3.4
GSH 3.4
fear and anxiety 3.4
vitamin B12 deficiency 3.3
impotence 3.2
tubular necrosis 3.2
Thymus 3.2
Thymus 3.2
Thymus 3.2
Krabbe disease 3.2
neuromuscular disorder 3.1
pheochromocytoma 3.1
G6PD deficiency 3.1
Schmidt 3.1
chronic glomerulonephritis 3.1
SDS 3.1
hepatoblastoma 3.1
brain dysfunction 3.1
immaturity 3.0
Fox 3.0
DES 3.0
neoplastic process 3.0
MICA 3.0
postherpetic neuralgia 2.9
primary biliary cirrhosis 2.8
trypanosomiasis 2.8
Mycoplasma 2.8
lymphosarcoma 2.8
metabolic disorder 2.8
epididymis 2.8
SCH 2.8
myopathy 2.8
EDC 2.7
erectile dysfunction 2.7
Fibrillation 2.7
sleep disorders 2.7
uropathy 2.7
Luminal 2.7
more...
Symptom
Decreased activity 4.4
ketonuria 4.4
orofacial pain 3.6
eds 3.4
urinary frequency 3.4
abnormal gait 3.4
nasal congestion 3.3
chronic constipation 3.2
tonic-clonic seizure 3.1
hypotonia 3.0
anosmia 2.9
incoordination 2.7
memory loss 2.7
twitching 2.5
ataxia 2.3
pallor 2.2
tachypnea 2.2
functional recovery 2.1
ophthalmoplegia 1.8
starvation 1.7
cyanosis 1.6
anorexia 1.3
acute stress 1.3
constipation 1.2
lethargy 1.0
seizures 1.0
hypothermia 1.0
hepatomegaly 1.0
hemoptysis 0.9
weakness 0.9
fatigue 0.8
spasticity 0.8
myalgia 0.8
arthralgia 0.7
dystonia 0.5
collapse 0.3
respiratory distress 0.2
thinning 0.0
agitation -0.1
sleepiness -0.1
stigma -0.2
pain -0.3
analgesia -0.3
acidity -0.4
anesthesia -0.4
vomiting -0.5
nausea -1.0
dyspnea -1.3
headache -1.3
abdominal pain -1.4
Drug
Cocarboxylase 10.7
FAD 8.5
NADH 8.4
Atabrine 7.6
Phenprocoumon 7.0
Flavin 6.7
Trypanothione 6.5
Fenbendazole 6.2
NBT 6.1
Vardenafil 6.1
Ethylenediamine 5.7
Kainic acid 5.7
Trifluoperazine 5.7
Cibacron Blue 5.6
Riboflavin 5.5
Photofrin II 5.5
Vitamin K 5.4
DFP 5.2
Sodium valproate 5.2
Captopril 4.9
pyridoxal phosphate 4.8
Aminoguanidine 4.8
L-tyrosine 4.6
Sodium nitroprusside 4.6
Clofibrate 4.4
GHRP 4.4
Apomorphine 4.2
Methylene blue 4.2
Nitric Oxide 4.2
AGG 3.9
Gastro 3.7
ascorbate 3.5
Glutathione 3.4
citric acid 3.4
Fraction 3.2
Amiloride 2.9
MgSO4 2.9
Heme 2.9
TAC 2.8
Ginseng 2.8
Simvastatin 2.8
PTC 2.7
Amiloride 2.7
Gel 2.6
niacin 2.6
lysine 2.6
Ethanol 2.6
THF 2.5
Paraffin 2.4
Glycerol 2.3
Fragment 2.3
TAT 2.3
Clonidine 2.3
Ouabain 2.2
HCG 2.1
Bifidobacterium 2.0
Taxol 1.9
ROS 1.8
Vitamin E 1.8
PCP 1.6
p75 1.6
Portal 1.5
caffeine 1.4
Adriamycin 1.3
Albumin 1.3
Mutagen 1.0
EE2 0.6
DNase I 0.5
vitamin E 0.4
Nephron 0.4
CTX 0.2
TiO2 0.0
Asn -0.0
IL-2 -0.3
MAP -0.4
lactose -0.5
Leaf -0.9
Cardiovasc -2.1
Dermatol -3.5
Enzyme
diaphorase 13.5
4NQO reductase 13.5
asparagusate dehydrogenase 13.5
malate-lactate transhydrogenase 13.5
2-methylisocitrate dehydratase 12.5
NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase 12.5
NADPH-diaphorase 12.5
ferric leghemoglobin reductase 12.2
lipoate acetyltransferase 12.0
dihydrolipoyl transacylase 12.0
bis-gamma-glutamylcystine reductase 11.9
diaphorase 11.9
NQO1 11.8
dihydrolipoamide succinyltransferase 11.7
EC 1.1.1.108 11.5
12alpha-hydroxysteroid dehydrogenase 11.2
2-oxoisovalerate dehydrogenase 11.2
p-benzoquinone reductase 11.2
D-sorbitol dehydrogenase 10.6
4-N-trimethylaminobutyraldehyde dehydrogenase 10.3
bidirectional hydrogenase 10.2
2-oxoglutarate decarboxylase 10.2
mercuric reductase 10.1
NAD+ synthetase 10.0
diacetyl reductase 10.0
alpha-ketoglutarate dehydrogenase 9.9
4-hydroxyproline 2-epimerase 9.9
glycine reductase 9.9
coenzyme A disulfide reductase 9.8
branched-chain alpha-keto acid dehydrogenase 9.8
adrenodoxin reductase 9.7
PdxJ 9.5
proteasome ATPase 9.5
4-hydroxybutyrate dehydrogenase 9.5
BCKA 9.4
pyruvate dehydrogenase 9.4
pyruvate dehydrogenase 9.4
T-protein 9.3
pyruvate dehydrogenase 9.3
nicotinic acid hydroxylase 9.2
glutathione oxidase 9.2
D-galactose dehydrogenase 9.1
acylcarnitine hydrolase 9.1
allantoate amidohydrolase 8.9
trypanothione reductase 8.8
glycine decarboxylase 8.8
NADH peroxidase 8.8
glycine dehydrogenase 8.8
glycine dehydrogenase 8.8
pyruvate decarboxylase 8.7
chorismate synthase 8.7
3beta-HSDH 8.7
fructose-6-phosphate phosphoketolase 8.6
NADH-cytochrome b5 reductase 8.6
beta-hydroxybutyrate dehydrogenase 8.5
EC 1.1.1.47 8.5
oxoglutarate dehydrogenase 8.5
hydroxyprostaglandin dehydrogenase 8.5
organomercurial lyase 8.3
acetate CoA-transferase 8.3
oligoribonuclease 8.3
IMP cyclohydrolase 8.2
nicotinamide adenine dinucleotide glycohydrolase 8.2
glycine dehydrogenase 8.1
transhydrogenase 8.1
NAD+ kinase 8.1
butyrate kinase 8.1
pyruvate dehydrogenase phosphatase 8.0
desulfinase 8.0
phosphotransbutyrylase 8.0
dihydrodipicolinate reductase 7.9
leucine dehydrogenase 7.9
EC 1.7.7.1 7.9
PTR1 7.8
glycerol-3-phosphate oxidase 7.8
electron transfer flavoprotein dehydrogenase 7.7
NAD+ oxidoreductase 7.7
sarcosine dehydrogenase 7.7
disulfide reductase 7.7
succinic dehydrogenase 7.6
flavin reductase 7.6
MetE 7.6
urocanase 7.5
NO synthase 7.5
D-dopachrome tautomerase 7.5
thioredoxin reductase 7.4
lactic acid dehydrogenase 7.4
aspartate semialdehyde dehydrogenase 7.4
arginyl-tRNA synthetase 7.4
Dm-dNK 7.3
nicotinic acid phosphoribosyltransferase 7.3
glycerol-3-phosphate dehydrogenase 7.3
glycerol-3-phosphate dehydrogenase 7.3
PDH 7.3
FADS 7.3
glycerol dehydrogenase 7.3
LipB 7.2
EC 4.4.1.5 7.2
lactic acid dehydrogenase 7.2
octopine dehydrogenase 7.2
glycerol dehydrogenase 7.2
argininosuccinate lyase 7.1
NAD glycohydrolase 7.1
butyryl-CoA dehydrogenase 7.1
bilirubin oxidase 7.1
fumarase 7.1
pyruvate oxidase 7.0
glutathione reductase 7.0
pyruvate oxidase 7.0
STK2 7.0
NADH dehydrogenase 7.0
glucose dehydrogenase 7.0
heterodisulfide reductase 6.9
succinate dehydrogenase 6.9
CPR 6.8
quinolinic acid phosphoribosyltransferase 6.8
NOS 6.8
peptidyl-tRNA hydrolase 6.8
ferredoxin reductase 6.8
glutamic dehydrogenase 6.7
pyrroline-5-carboxylate dehydrogenase 6.6
isocitrate dehydrogenase 6.6
formate dehydrogenase 6.6
azoreductase 6.6
amidophosphoribosyltransferase 6.6
formate dehydrogenase 6.6
formate dehydrogenase 6.6
glutamate racemase 6.6
allantoinase 6.6
esterase D 6.5
nicotinamide mononucleotide adenylyltransferase 6.5
malate dehydrogenase 6.5
glucose-6-phosphate dehydrogenase 6.5
MDH 6.4
choline acetyltransferase 6.4
aconitase 6.4
alanine dehydrogenase 6.4
succinyl-CoA synthetase 6.4
argininosuccinate synthetase 6.4
EC 3.6.1.1 6.4
citrate lyase 6.4
hydrogenase 6.4
hydrogenase 6.4
nitrite reductase 6.3
MDH 6.3
nitrite reductase 6.3
nitrite reductase 6.3
UMP kinase 6.3
serine hydroxymethyltransferase 6.3
nitrate reductase 6.3
shikimate dehydrogenase 6.3
D-amino-acid oxidase 6.3
isocitrate dehydrogenase 6.3
lactic acid dehydrogenase 6.2
cysteine conjugate beta-lyase 6.2
p-hydroxybenzoate hydroxylase 6.2
acetate kinase 6.2
6-phosphogluconate dehydrogenase 6.2
6-phosphogluconate dehydrogenase 6.2
MsrA 6.1
more...
Compound
Asparagusate 13.5
S-Methylisothiourea sulfate 13.5
Optochin hydrochloride 13.5
dihydrolipoamide 12.4
1-bromoheptane 12.1
5-Methoxyindole 11.5
CB 1954 11.4
spirost-5-en-3-ol 11.2
Trichloropropene oxide 10.9
2-Fluoroadenine 10.9
TNBT 10.6
EH2 10.3
Menadiol 10.2
Lipozyme 10.1
Dihydrolipoic acid 9.8
DEPA 9.6
S-(carboxymethyl)cysteine 9.3
S-(carboxymethyl)cysteine 9.3
Ferredoxin 9.3
p-Nitrobenzoic acid 9.2
nicotinamide 9.2
DEPA 9.2
NMOR 9.1
L-dopachrome 9.0
Fe(CN)3 8.9
Nitrofuran 8.9
1,3-Dinitrobenzene 8.7
2-nitroso-1-naphthol 8.6
Ferricyanide 8.5
FAD 8.5
Chorismate 8.4
2-methylcitric acid 8.4
NADH 8.4
2-hydroxybutanoic acid 8.3
2-oxoadipate 8.3
2,6-dichlorophenol 8.2
Chicago Sky Blue 6B 8.2
7-Ethoxyresorufin 8.2
Avertin 8.1
DCIP 8.1
NADPH 8.0
NADPH 8.0
2-hydroxybutanoic acid 8.0
Pyrithiamine 8.0
Vitamin K epoxide 7.9
BHC 7.9
NADP 7.9
hydroxytyramine 7.8
Ethylparaben 7.8
Ferrocyanide 7.8
Phenanthrenequinone 7.7
3-buten-2-one 7.6
DPN 7.6
3-buten-2-one 7.5
NAD 7.5
NAD 7.4
D-Arginine 7.4
Acetyl phosphate 7.3
C3H7NO 7.2
FMNH 7.2
Nifurtimox 7.1
Molybdenum cofactor 7.1
allantoate 7.1
C3H7NO 7.0
1,2-dithiolane 7.0
N'-methylnicotinamide 7.0
Phenothiazine 7.0
FCB 7.0
Diethyl pyrocarbonate 7.0
Lip 7.0
DTE 6.9
SCMC 6.9
1,2,4-benzotriazine 6.9
Trp-P-2 6.9
Dehydroascorbic acid 6.9
Mercaptopropionic acid 6.9
Phenylarsine oxide 6.8
Copper sulfate 6.8
FMN 6.7
ethyl formate 6.7
Chloroacetaldehyde 6.7
PDH 6.7
glutaryl-CoA 6.7
Resazurin 6.6
2-oxoglutarate 6.6
INT 6.6
naphthoquinone 6.6
naphthoquinone 6.6
naphthoquinone 6.6
naphthoquinone 6.6
naphthoquinone 6.6
docosanoic acid 6.6
3,4-dihydroxybenzaldehyde 6.6
naphthoquinone 6.6
Triphosphate 6.6
1,4-butanediamine 6.5
CoQ9 6.5
naphthoquinone 6.5
22R-hydroxycholesterol 6.5
N-methylnicotinamide 6.4
DLA 6.4
NBT 6.4
NMN 6.3
2-Oxoglutarate 6.3
Biocytin 6.3
2-furoic acid 6.3
Flavin 6.3
Cyclic ADP-ribose 6.2
DBB 6.2
Malonate 6.2
3,4-dihydroxybenzaldehyde 6.2
DCVC 6.2
2-furoic acid 6.2
FANFT 6.2
TPP 6.1
6-phosphogluconate 6.1
alpha-ketoisocaproate 6.1
KIV 6.0
isopropylbenzene 6.0
acetyl-CoA 6.0
Barbiturate 5.9
3-hydroxybutyric acid 5.9
nitric oxide 5.9
Glycerol-3-phosphate 5.8
CIT 5.8
Diosgenin 5.8
isocitrate 5.8
Fumarate 5.8
Kainic acid 5.7
Kainic acid 5.7
phosphate 5.7
Quinacrine 5.7
8-Br-cGMP 5.7
Trifluoperazine 5.7
BHA 5.7
Plumbagin 5.7
phenazine 5.7
Quinone 5.6
Pyruvate 5.6
2-oxobutyrate 5.6
MGBG 5.6
MGBG 5.6
3-hydroxy-2-butanone 5.6
nitrosobenzene 5.5
Nitro-L-arginine 5.5
Digitonin 5.5
2-furoic acid 5.5
Arsenate 5.5
Nicotinic acid adenine dinucleotide phosphate 5.5
Riboflavin 5.4
Nicotinic acid adenine dinucleotide phosphate 5.4
Coenzyme A 5.4
ADP-glucose 5.4
Cyanine 5.4
Rotenone 5.4
5H-pyrido[4,3-b]indole 5.4
DMPP 5.4
Formate 5.4
ubiquinol 5.3
T13 5.3
more...