Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.8.1.4 (
diaphorase
)
2,754
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of DT
diaphorase
on the cytotoxicity (reduction in colony formation frequency) of menadione and 4-nitroquinoline-1-oxide (4NQO) was examined in two fibroblastic cell lines (Chinese hamster V79H3 cells and
NG2
Syrian hamster cells). The addition of dicoumarol (10(-4) M-3 x 10(-4) M), a specific inhibitor of DT
diaphorase
, resulted in an intensification of the cytotoxicity of menadione, supporting the hypothesis that DT
diaphorase
protects cells against the oxidative stress induced by quinones. On the other hand, the toxicity of 4NQO was greatly reduced by the addition of dicoumarol (10(-5) M-3 x 10(-4) M), showing that DT
diaphorase
is the key (or the sole) enzyme involved in the activation of 4NQO in the above cells.
...
PMID:Role of DT diaphorase the cytotoxicity of menadione and 4-nitroquinoline-1-oxide in cultured mammalian fibroblastic cells. 170 87
