Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: EC:1.7.1.4 (
nitrite reductase
)
1,847
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of a non-selective blocker of NO synthases LNNA in a dose of 25 mg/kg and nitrates KNO
3
, NaNO
3
, Mg(NO
3
)
2
, and Ca(NO
3
)
2
in doses of 5 and 50 mg/kg were studied on the model of experimental ischemic
stroke
induced by bilateral occlusion of the common carotid arteries. Wistar rats were randomized into 40 treatment (n=960) and 8 control (n=192) groups. Treatment group rats received injection of either nitrate, or LNNA, or a combination LNNA+nitrate. All substances were administered intraperitoneally 1 h prior to brain ischemia or 5 sec after occlusion of the common carotid arteries. Control rats received the same volume of 0.9% NaCl at the same terms. The non-selective inhibitor of NO synthases LNNA administered against the background of brain ischemia increased neurological deficit and animal mortality. Nitrate/
nitrite reductase
system had protective properties depending on the cation of nitrate and concentration of a nitrate during inhibition of NO synthase system under conditions of brain ischemia and hypoxia.
...
PMID:Protective Role of Nitrate/Nitrite Reductase System during Transient Global Cerebral Ischemia. 2979 13
