Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.7.1.2 (
nitrate reductase
)
3,861
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Nitric oxide is hypothesised to play a role in the immunopathogenesis of
multiple sclerosis
. Raised cerebrospinal fluid and serum levels of the nitric oxide metabolites nitrate and nitrite have been described in patients with
multiple sclerosis
. Cerebrospinal fluid and serum nitrate and nitrite were measured in patients with
multiple sclerosis
, inflammatory and non-inflammatory neurological diseases, and correlated with the albumin quotient, an index of blood-brain-barrier dysfunction. Patients undergoing diagnostic lumbar and vene puncture were prospectively recruited, clinical data were obtained from the hospital records, and the CSF and serum nitrate and nitrite levels were measured by the
nitrate reductase
and Griess reaction methods. Nitrate and nitrite, were raised in the CSF and serum of patients with
multiple sclerosis
and other inflammatory neurological diseases compared to patients with non-inflammatory neurological disorders (median nitrate and nitrite: cerebrospinal fluid = 10.3 microM vs 15.4 microM vs 6.6 microM, P < 0.001, and serum = 49.0 microM vs 46.4 microM vs 38.8 microM, P = 0.02, respectively). CSF nitrate and nitrite levels correlated with the albumin quotient (n = 59, r = 0.42, P < 0.001). This study provides further evidence for a role of nitric oxide in the immunopathogenesis of
multiple sclerosis
and supports a role for nitric oxide as a possible mediator of inflammatory blood-brain-barrier dysfunction.
...
PMID:Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis. 953 89
Multiple sclerosis
is a disease characterized by perivascular infiltrates and demyelination of the white matter in the central nervous system. In this study, we compared the serum and cerebrospinal fluid nitric oxide levels before and after methylprednisolone therapy, and during remission period, and investigated the relationship of nitric oxide to the activity of
multiple sclerosis
. Cerebrospinal fluid and serum nitric oxide levels were measured blind as nitrite plus nitrate, using the
nitrate reductase
and Griess reaction method in 20 patients with
multiple sclerosis
before and after corticosteroid therapy, and during remission period, and in 20 control subjects. Mean cerebrospinal fluid and serum nitric oxide levels were highest in the pretreatment group and lowest in the control group. There was no correlation with nitric oxide levels in these two groups. Although corticosteroid therapy did not have any great effect on Expanded Disability Status Scales, it led to a decrease in nitric oxide levels. The possible cause of this might be the inhibition of nitric oxide synthesis by methylprednisolone, or a decrease in
multiple sclerosis
activity. We conclude that serum or cerebrospinal fluid nitric oxide levels do not reflect the activity in
multiple sclerosis
.
...
PMID:The effect of corticosteroids on serum and cerebrospinal fluid nitric oxide levels in multiple sclerosis. 1160 81
