Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.7.1.2 (nitrate reductase)
 3,861 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Until now, only a few strains of V. cincinnatiensis have been isolated. This study describes a further three isolates which originated in one case from a stool specimen of an immunocompromised elder patient suffering from enteritis and in two cases from the rennin stomachs of aborted bovine fetuses. These strains grew on TCBS, CIN, MacConkey and XLD plates. Their biochemical activities were dependent on NaCl concentration, in particular the formation of indole, lysine and ornithine decarboxylases, arginine dihydrolase, the reduction of nitrate and behaviour in the Voges-Proskauer test. Moreover, lysine decarboxylase and nitrate reductase were temperature-dependent. The knowledge of these hitherto unknown phenotypical characteristics may facilitate the diagnosis of the pathogen.
 ...
PMID:Contribution to some phenotypical characteristics of Vibrio cincinnatiensis. Studies in one strain of a diarrhoeic human patient and in two isolates from aborted bovine fetuses. 830 3

Campylobacter jejuni is an important human pathogen that causes millions of cases of food-borne enteritis each year. The C. jejuni respiratory chain is highly branched and contains at least four enzymes predicted to contain a metal binding pterin (MPT), with the metal being either molybdenum or tungsten. Also predicted are two separate transport systems, one for molybdenum encoded by modABC and a second for tungsten encoded by tupABC. Both transport systems were mutated and the activities of the four predicted MPT-containing enzymes were assayed in the presence of molybdenum and tungsten in wild-type and mod and tup backgrounds. Results indicate that mod is primarily a molybdenum transporter that can also transport tungsten, while tup is a tungsten-specific transporter. The MPT containing enzymes nitrate reductase, sulphite oxidase, and SN oxide reductase are strict molybdoenzymes while formate dehydrogenase prefers tungsten. A ModE-like protein regulates both transporters, repressing mod in the presence of both molybdenum and tungsten and tup only in the presence of tungsten. Like other ModE proteins, the C. jejuni ModE binds DNA through a helix-turn-helix DNA binding domain, but unlike other members of the ModE family it does not have a metal binding domain.
 ...
PMID:Molybdenum and tungsten in Campylobacter jejuni: their physiological role and identification of separate transporters regulated by a single ModE-like protein. 1991 2