Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.5 (NADH dehydrogenase)
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Human Gene/Protein
outer dense fiber protein 2 13.9
actin-related protein T2 13.9
EF-hand domain-containing protein 1 13.9
NDUFV2 protein 13.9
NADH dehydrogenase 13.9
Matrilin 3 12.9
dehydrogenase/reductase member 3 12.9
Ribosomal protein S18 12.9
mitochondrial malate dehydrogenase 2, NAD 12.9
GTP-binding protein SAR1 12.9
CECR2B 12.9
C1QL4 12.9
G8 protein 12.9
NADH dehydrogenase III 12.9
iron-sulfur protein 3 12.7
ATP synthase D chain, mitochondrial 12.3
Ribosomal protein L15 12.3
40S ribosomal protein S23 12.3
tripartite motif-containing 14 12.3
MTND4 12.0
pyruvate dehydrogenase (lipoamide) beta 11.9
SDHA protein 11.9
Ras-related protein Rab-2A 11.9
SLC25A14 11.9
troponin C2 11.9
mitochondrial ribosomal protein L12 11.9
NADH-ubiquinone oxidoreductase chain 1 11.9
ATP synthase gamma chain 11.9
MURF2 11.7
complex I) 11.5
cytochrome c oxidase subunit 3 11.4
RAD23 homolog B 11.3
MTND3 11.3
hemoglobin alpha 2 11.3
Glutathione S-transferase kappa 1 11.3
karyopherin beta 1 11.3
MT-ND2 11.2
Fas-activated serine/threonine kinase 11.2
SRP40 11.1
ATP synthase F0 subunit 6 11.1
LEP503 11.1
CaM-KIIN 11.1
nucleotide binding protein-like 11.1
ATPase subunit 6 11.0
Nuclear apoptosis-inducing factor 1 10.9
RAB-14 10.9
NDUFB5 10.9
SQM1 10.9
Septin-2 10.9
NADH dehydrogenase subunit 4L 10.9
URF2 10.9
NDUFA7 10.9
brain mitochondrial carrier protein-1 10.9
Multidrug resistance protein 3 10.9
ATP5L 10.9
MTCO1 10.7
apolipoprotein A-I binding protein 10.7
MTND6 10.7
NDUFA10 10.7
PGR5 10.6
NDUFB10 10.6
NDUFS2 10.6
IDI2 10.5
ATPase homolog 10.5
TYKY 10.5
MT-ND4 10.5
cytochrome c, somatic 10.5
PSST 10.5
ND4L 10.5
NADH-ubiquinone reductase 10.5
NADH-ubiquinone oxidoreductase 10.5
MITOCHONDRIAL 10.5
MT-ND5 10.5
tryptase beta I 10.4
UQCRH 10.4
Cytochrome c oxidase subunit 1 10.4
MTND5 10.4
HRPAP20 10.4
IDH3B 10.4
rlf 10.4
EXOSC9 10.4
complex I assembly factor 10.4
NDUFS7 10.3
PSST subunit 10.3
tRNA-Arg 10.3
NADH: ubiquinone oxidoreductase 10.3
NDUFS6 10.3
NDUFA4L2 10.3
cytochrome c oxidase subunit III 10.3
NDUFV1 10.2
NDUFC2 10.2
ATPase subunit 8 10.2
HNRNPH2 10.2
NDUFV2 10.2
NDUFAB1 10.2
cytochrome oxidase subunit III 10.2
ropporin 10.2
NADH1 10.2
ND1 10.1
ND5 10.1
MYH15 10.1
NUBPL 10.1
NDUFB9 10.1
succinate dehydrogenase flavoprotein subunit 10.1
NDUFS3 10.0
Malic dehydrogenase 10.0
ret finger protein 10.0
NQO2 9.9
ND3 9.9
NDUFA5 9.9
calmodulin 2 9.9
PRELI 9.9
BRAP2 9.9
MIA40 9.9
NDUFA11 9.8
TM14 9.8
p47 protein 9.8
NDUFA2 9.8
NADH dehydrogenase subunit 3 9.8
MTND1 9.8
ATPase 6 9.8
ND4 9.7
ATP synthase subunit 6 9.7
putative oxidoreductase 9.7
NDUFS4 9.6
GPAA1 9.6
NDUFA1 9.6
ND2 9.5
COX5B 9.5
DCC1 9.5
UQCRC2 9.5
FAD pyrophosphorylase 9.5
ATPase subunit 9 9.4
NDUFA4 9.4
COX3 9.4
MT-ND3 9.3
UQCRC1 9.3
ND6 9.3
ubiquinone-binding protein 9.3
COQ8 9.3
ALG8 9.3
NADH dehydrogenase subunit 5 9.2
ubiquitously expressed transcript 9.2
CHCHD4 9.2
cytochrome oxidase subunit II 9.2
ornithine transporter 9.2
ABAD 9.2
ADP-dependent glucokinase 9.2
thiosulfate sulfurtransferase 9.2
QCR8 9.2
NDUFB8 9.1
ALDH9 9.1
pdhB 9.1
RPL8 9.1
ribosomal protein S3a 9.1
ATP-dependent glucokinase 9.1
NDE1 9.0
NADH dehydrogenase subunit 6 9.0
ubiquinone 9.0
TRIP12 9.0
more...
Disease
Brisket disease 12.3
nanophyetiasis 11.1
Chromophobe cell renal carcinoma 10.7
SCA28 9.6
Complex I deficiency 8.9
SPG20 8.4
Diabetic encephalopathy 8.2
Leber's hereditary optic neuropathy 7.9
pediatric disorder 7.7
SPG7 7.5
NDI 7.4
Echinococcus granulosus infection 7.4
White Spot 7.4
mitochondrial myopathy 7.3
Leigh syndrome 7.3
coenurosis 7.3
mitochondrial encephalomyopathy 7.2
marijuana abuse 7.1
Cogan 7.1
Barth syndrome 6.9
Optic neuropathy 6.6
Kearns-Sayre syndrome 6.5
mitochondrial disease 6.2
Diaz 6.2
MERRF 6.2
Dicrocoelium dendriticum 6.1
MELAS 6.0
MELAS 5.7
riboflavin deficiency 5.7
PPR 5.7
testicular dysfunction 5.6
Schistosoma japonicum 5.6
DIA 5.6
chondrolysis 5.5
PCC 5.4
Crouzon syndrome 5.4
optic atrophy 5.3
dyschondroplasia 5.3
Benson 5.2
FDH 5.2
enterobiasis 5.1
AGA 5.0
Onchocerciasis 4.9
CAA 4.9
Persistent infection 4.9
KMS 4.9
Echinococcus 4.9
tapeworm 4.9
lactic acidosis 4.8
visual dysfunction 4.8
Peripheral arterial disease 4.8
NCR 4.7
Zinc deficiency 4.7
Colon cancer 4.7
fascioliasis 4.7
Rocky Mountain spotted fever 4.6
aggressive lymphoma 4.6
KNO 4.6
CAA 4.5
Hymenolepis 4.5
enzyme deficiency 4.4
DMT1 4.4
Dystonia 4.4
achondroplasia 4.4
Chronic infection 4.3
ADH 4.3
PDR 4.3
multiple disorders 4.2
pheochromocytoma 4.2
metritis 4.1
MDI 4.1
tinea capitis 4.1
malignant ascites 4.1
GBS 4.0
photosensitivity 3.8
Friedreich's ataxia 3.8
Menkes 3.8
Venezuelan equine encephalitis 3.8
onchocerciasis 3.7
myiasis 3.7
cocaine addiction 3.7
craniosynostosis 3.7
refractory anemia 3.7
SRS 3.7
typhus 3.7
bovine leukemia 3.6
thiamine deficiency 3.6
STS 3.6
trichomoniasis 3.5
neuromuscular disorder 3.5
myopathy 3.5
GSH 3.4
CES 3.4
spastic paraplegia 3.4
cocaine abuse 3.3
PAF 3.3
Neumann 3.3
L. infantum 3.3
plant disease 3.2
Mycobacterium 3.2
LAD 3.2
SAD 3.2
Parkinson's disease 3.1
EDC 3.1
cancer recurrence 3.1
mastocytoma 3.1
Dependence 3.0
dilated cardiomyopathy 3.0
scotoma 3.0
AS1 3.0
Endothelial dysfunction 3.0
NHL 2.9
LCA 2.9
ketosis 2.9
SDS 2.9
FAS 2.9
hookworm 2.8
Chagas 2.8
chlorosis 2.8
Neuroblastoma 2.7
Neuroblastoma 2.7
proliferative diabetic retinopathy 2.7
THC 2.7
chikungunya 2.7
iron deficiency 2.6
catalepsy 2.6
parkinsonism 2.6
hypertrophic cardiomyopathy 2.6
Age-related macular degeneration 2.6
childhood ALL 2.6
EMA 2.6
ARC 2.6
tuberculosis 2.5
leprosy 2.5
muscular atrophy 2.5
parasitic disease 2.5
hepatoblastoma 2.4
rumination 2.4
coxsackievirus 2.4
apraxia 2.4
EMT 2.4
motor neuron disease 2.4
cholera 2.4
muscular dystrophy 2.3
ACP 2.3
cardiomyopathy 2.3
schistosomiasis 2.3
PLS 2.3
AAA 2.3
Recruitment 2.2
heart block 2.2
CAP 2.2
hyperhomocysteinemia 2.2
sclera 2.2
worms 2.1
PDB 2.1
neuroblastoma 2.1
fatty liver 2.1
ischemia 2.1
IBM 2.1
more...
Symptom
Respiration stimulated 12.9
ophthalmoplegia 4.5
hyperoxia 3.8
eds 3.8
dysarthria 3.6
hypotonia 3.3
cerebellar ataxia 3.0
starvation 3.0
chorea 2.8
myoclonus 2.8
pallor 2.6
dystonia 2.4
lethargy 2.4
exertional dyspnea 2.1
exhaustion 1.7
weakness 1.7
paresis 1.4
hypercapnia 0.9
ataxia 0.9
fatigue 0.8
collapse 0.1
acidity -0.0
tremor -0.3
anesthesia -1.3
diarrhea -1.9
seizures -2.4
Drug
Nanaomycin D 12.3
Duroquinone 10.3
Tuareg 9.2
URF 8.9
NADH 8.7
Secobarbital 8.6
Demerol 8.4
Demerol 7.8
FAD 7.4
Sodium thiosulfate 7.3
Flavin 7.0
Vanilla 6.7
Abamectin 6.7
Isoniazid 6.3
AGG 6.2
Novantrone 6.2
Cibacron Blue 6.0
Photofrin II 5.8
Geranium 5.8
Dexon 5.5
SMP 5.3
Bosentan 5.1
Bosentan 5.1
Emodin 5.0
Fructose 5.0
EHDP 4.9
Clofibrate 4.7
Emodin 4.7
NaI 4.6
NaI 4.6
NaI 4.6
NaI 4.6
Adriamycin 4.5
Glycerol 4.3
Riboflavin 4.3
Ranitidine 4.2
citric acid 4.2
Xanthium 4.2
ROS 4.1
Photofrin 4.0
Parkin 4.0
Parkin 4.0
ascorbate 3.6
Arsenic trioxide 3.5
Nitric Oxide 3.5
Asn 3.5
NBT 3.5
AZT 3.5
Glutathione 3.5
Meth 3.5
Vitamin K 3.4
IPM 3.3
Amiloride 3.3
Sorafenib 3.3
AZT 3.3
BH4 3.3
GEO 3.3
ADM 3.2
Bayer 3.2
DNase I 3.2
Tacrolimus 3.2
Amiloride 3.0
Gel 3.0
TTC 3.0
ADR 2.9
Propofol 2.8
PCB 2.8
G418 2.7
Capsicum 2.7
TAT 2.6
Ethanol 2.6
Imatinib 2.6
Fraction 2.5
ALA 2.4
Growth hormone 2.3
Growth hormone 2.3
Heme 2.3
Vitamin E 2.2
Glucagon 2.0
p75 1.9
lysine 1.8
vitamin E 1.8
ICI 1.5
lactose 1.4
Histamine 1.4
Mutagen 1.3
Indomethacin 1.2
CaCl2 1.2
CaCl2 1.2
CaCl2 1.2
NH3 1.1
Leaf 1.0
Biopolymers 0.8
ABC 0.8
nitroglycerin 0.7
Nephron 0.7
ampicillin -0.2
IFN-gamma -1.0
Cardiovasc -1.7
Dermatol -3.1
Enzyme
NADH dehydrogenase 13.9
diaphorase 12.3
EC 3.2.1.70 12.3
complex I 11.8
EC 1.1.99.16 10.9
4-N-trimethylaminobutyraldehyde dehydrogenase 10.7
malate oxidase 10.6
mannitol-1-phosphatase 10.2
glutaconyl-CoA decarboxylase 9.9
6-phosphogluconate dehydratase 9.5
DHOdehase 9.5
KGOR 9.4
ADP-dependent glucokinase 9.2
thiosulfate dehydrogenase 9.1
NQO2 9.1
methylmalonyl-CoA epimerase 8.9
ubiquinol-cytochrome c oxidoreductase 8.8
succinate dehydrogenase 8.7
transhydrogenase 8.6
mannitol 1-phosphate dehydrogenase 8.5
EC 1.1.1.39 8.5
thiosulfate dehydrogenase 8.4
dihydrodipicolinate reductase 8.3
heterodisulfide reductase 8.3
bidirectional hydrogenase 8.3
fumarate reductase 8.3
proline dehydrogenase 8.2
phospho-beta-glucosidase 8.2
3-hydroxybutyryl-CoA dehydrogenase 8.1
lactate oxidase 8.1
succinic dehydrogenase 8.1
alpha-ketoglutarate dehydrogenase 8.1
pyruvate:ferredoxin oxidoreductase 8.0
Delta6-desaturase 7.9
membrane-bound hydrogenase 7.9
deoxyhypusine hydroxylase 7.8
D-dopachrome tautomerase 7.8
phosphoenolpyruvate synthase 7.8
glycerol 3-phosphate dehydrogenase 7.8
cytochrome oxidase 7.8
2,3-butanediol dehydrogenase 7.8
SirA 7.8
dihydrolipoamide succinyltransferase 7.7
malate dehydrogenase 7.7
ATP synthase 7.6
PAF acetyltransferase 7.6
lactic acid dehydrogenase 7.6
dihydroxyacetone kinase 7.6
glycerol-3-phosphate dehydrogenase 7.6
isoflavone reductase 7.6
lactic acid dehydrogenase 7.6
glycerol-3-phosphate dehydrogenase 7.5
acetoacetyl-CoA thiolase 7.5
butyryl-CoA dehydrogenase 7.5
isocitrate dehydrogenase 7.4
coproporphyrinogen III oxidase 7.4
NADH-cytochrome b5 reductase 7.4
pyruvate oxidase 7.4
pyruvate oxidase 7.4
CPR 7.4
isovaleryl-CoA dehydrogenase 7.3
isocitrate dehydrogenase 7.2
flavin reductase 7.2
oxalate decarboxylase 7.1
NQO1 7.1
glucose permease 7.1
L-serine dehydratase 7.0
mercuric reductase 7.0
diaphorase 7.0
formate dehydrogenase 6.9
formate dehydrogenase 6.9
fumarase 6.9
dihydroorotate dehydrogenase 6.9
dihydroorotate dehydrogenase 6.9
coproporphyrinogen oxidase 6.9
ADH3 6.8
riboflavin kinase 6.8
formate dehydrogenase 6.8
succinyl-CoA synthetase 6.8
3-hydroxyacyl-CoA dehydrogenase 6.8
aconitase 6.7
shikimate dehydrogenase 6.6
D-amino-acid oxidase 6.6
FADS 6.6
lactic acid dehydrogenase 6.6
deoxyhypusine synthase 6.6
NADPH-diaphorase 6.6
hydrogenase 6.6
hydrogenase 6.5
oxoglutarate dehydrogenase 6.5
3-hydroxyacyl-CoA dehydrogenase 6.5
enoyl-ACP reductase 6.5
propionyl-CoA carboxylase 6.5
glucose dehydrogenase 6.5
enoyl-ACP reductase 6.4
propionyl-CoA carboxylase 6.4
sarcosine oxidase 6.4
CAO 6.4
pyruvate dehydrogenase 6.4
phytochelatin synthase 6.4
pyruvate dehydrogenase 6.4
pyruvate dehydrogenase 6.4
trypanothione reductase 6.4
violaxanthin de-epoxidase 6.4
azoreductase 6.4
sepiapterin reductase 6.3
ferrochelatase 6.3
mannitol dehydrogenase 6.3
nicotinamide phosphoribosyltransferase 6.3
triose-phosphate isomerase 6.3
beta-hydroxybutyrate dehydrogenase 6.3
betaine aldehyde dehydrogenase 6.3
valyl-tRNA synthetase 6.3
chloroperoxidase 6.2
MPP 6.2
aminopeptidase B 6.1
proton-translocating ATPase 6.0
histidase 6.0
3-mercaptopyruvate sulfurtransferase 6.0
acyl-CoA dehydrogenase 6.0
acetate kinase 6.0
SOR 6.0
peroxiredoxin 6.0
formaldehyde dehydrogenase 6.0
rhodanese 5.9
pantothenate kinase 5.9
isoleucyl-tRNA synthetase 5.9
SOR 5.9
acyl-CoA dehydrogenase 5.8
citrate synthase 5.8
condensing enzyme 5.8
MDH 5.7
6-phosphogluconate dehydrogenase 5.7
6-phosphogluconate dehydrogenase 5.7
EPT 5.7
nitrate reductase 5.6
nitrate reductase 5.6
p-nitrophenylphosphatase 5.6
protochlorophyllide oxidoreductase 5.6
protoporphyrinogen oxidase 5.5
nitrate reductase 5.5
sulfite reductase 5.5
sulfite reductase 5.5
SCS 5.5
nitrate reductase 5.5
nitrate reductase 5.5
nitrate reductase 5.5
sulfite reductase 5.5
phospholipid hydroperoxide glutathione peroxidase 5.4
fructokinase 5.4
glycerol kinase 5.3
nitrous oxide reductase 5.3
FAST 5.3
aldolase 5.3
manganese peroxidase 5.3
NADPH oxidase 5.2
MDH 5.2
ubiquitin-protein ligase 5.2
pyruvate kinase 5.2
dihydropteridine reductase 5.2
more...
Compound
Adriamycin aglycone 13.9
Rifamycin S 11.9
Syrosingopine 11.9
Xanthomegnin 11.5
Succinic acid monomethyl ester 11.3
Fenpyroximate 10.9
CoQ6 10.8
D-Carnitine 10.7
2-bromobenzoic acid 10.7
1,2,3-benzothiadiazole 10.5
Quinalizarin 10.4
5-Methoxyindole 10.3
Coproporphyrin III 10.2
3-succinoylpyridine 10.1
2,2',5,5'-TCB 10.0
Coproporphyrin III 9.9
Duroquinone 9.8
2,2,4-trimethyl-1,2-dihydroquinoline 9.7
Methacrylonitrile 9.7
D-Proline 9.5
Spartin 9.3
Sedoheptulose 9.2
Glyceollin 9.2
Glyceollin 9.2
1-Methyl-4-phenylpyridinium 9.0
ubiquinone 8.9
Janus Green B 8.9
NADH 8.7
Protopine 8.7
Adrenochrome 8.6
Ferricyanide 8.6
6-hydroxynicotinic acid 8.4
6-hydroxynicotinic acid 8.4
dimethyl succinate 8.4
FMN 8.2
Amytal 8.2
2,6-dichlorophenol 8.1
Enterobactin 8.1
Rotenone 8.1
L-lactaldehyde 8.0
protoporphyrinogen IX 8.0
ubiquinol 8.0
Quinone 8.0
3'-amino-3'-deoxythymidine 7.9
Ethoxyquin 7.9
Ethionamide 7.9
2,6-dibromophenol 7.9
2-chlorobenzoic acid 7.7
Antimycin 7.7
TMPD 7.7
Vinclozolin 7.7
1,2,3,6-tetrahydropyridine 7.6
Zafirlukast 7.6
1,2,3,6-tetrahydropyridine 7.6
CoQ 7.6
Deguelin 7.6
FMNH 7.5
Anthraquinone 7.5
TPB 7.5
Gramicidin S 7.5
FAD 7.3
Sodium deoxycholate 7.2
dihydroxyacetone-phosphate 7.2
dihydrolipoamide 7.2
TCTP 7.2
Ethionine 7.2
mannitol-1-phosphate 7.1
4-phenylpyridine 7.1
1-Nitropyrene 7.1
Malate 7.0
heptyl 7.0
heptyl 7.0
Tetrabenazine 7.0
Juglone 7.0
succinic acid 7.0
pimelic acid 6.9
NAD 6.9
NAD 6.9
S-allylcysteine 6.9
DCIP 6.9
Pyrroloquinoline quinone 6.8
Catalpol 6.8
3-chlorophenol 6.8
Rhein 6.8
Delphinidin 6.8
Deoxycholic acid 6.8
PCMB 6.7
PCMB 6.7
PCMB 6.7
PCMB 6.6
Cytochrome c 6.6
Flavin 6.6
Pyocyanin 6.6
Xanthohumol 6.6
Rifabutin 6.5
Thiram 6.4
ETH 6.4
4-OHT 6.4
2,4,6-tribromophenol 6.4
Gliotoxin 6.4
Tetrabromobisphenol A 6.4
Phenothiazine 6.3
COX 6.2
Flavone 6.2
Thiram 6.2
COI 6.2
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.2
2,4,6-tribromophenol 6.2
DGE 6.2
MPTP 6.2
DGE 6.2
Glycerol-3-phosphate 6.2
DGE 6.2
CDP-ethanolamine 6.2
Clofazimine 6.2
isocitrate 6.1
Fumarate 6.1
cyanide 6.1
MPP 6.1
meso-diaminopimelate 6.1
Diamide 6.1
DBCP 6.1
MPP 6.1
Sarcosine 6.1
Formoterol 6.0
DBI 6.0
PBG 5.9
Endosulfan 5.9
decyl 5.9
decyl 5.9
NADPH 5.9
NADPH 5.9
4-hydroxyphenylacetic acid 5.8
naphthoquinone 5.8
naphthoquinone 5.8
naphthoquinone 5.8
naphthoquinone 5.8
naphthoquinone 5.8
naphthoquinone 5.7
OCTA 5.7
naphthoquinone 5.7
Cyt 5.6
Enflurane 5.6
Na2S 5.6
Naringin 5.6
pyrroline-5-carboxylate 5.6
CCP 5.5
Cholic acid 5.5
3-(dimethylamino)propyl 5.5
6-Hydroxydopamine 5.5
nicotinamide 5.5
Lipozyme 5.4
NADP 5.4
superoxide radical 5.4
Thymoquinone 5.4
2-oxoglutarate 5.4
CoM 5.4
2-methoxyphenol 5.4
TBT 5.3
Lycopene 5.3
more...