Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.3 (diaphorase)
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Human Gene/Protein
NDUFV2 protein 12.4
EF-hand domain-containing protein 1 12.4
TRM112-like protein 12.4
hemoglobin gamma-G 12.4
outer dense fiber protein 2 12.4
NADH dehydrogenase 12.4
actin-related protein T2 12.4
diaphorase 12.4
CGI-49 12.4
NADH diaphorase 12.3
Ribosomal protein S18 11.4
NADH dehydrogenase III 11.4
G8 protein 11.4
Matrilin 3 11.4
mitochondrial malate dehydrogenase 2, NAD 11.4
dehydrogenase/reductase member 3 11.4
CECR2B 11.4
C1QL4 11.4
GTP-binding protein SAR1 11.4
iron-sulfur protein 3 11.3
Diaphorase 11.0
ubiquinone-binding protein 10.8
tripartite motif-containing 14 10.8
Ribosomal protein L15 10.8
UQCR 10.8
CD81 antigen 10.8
ferritin, light polypeptide 10.8
ATP synthase D chain, mitochondrial 10.8
40S ribosomal protein S23 10.8
outer dense fiber of sperm tails 2 10.8
MTND4 10.5
mitochondrial ribosomal protein L12 10.4
Ras-related protein Rab-2A 10.4
SLC25A14 10.4
pyruvate dehydrogenase (lipoamide) beta 10.4
pyruvate carboxylase, mitochondrial 10.4
NADH-ubiquinone oxidoreductase chain 1 10.4
ATP synthase gamma chain 10.4
troponin C2 10.4
SDHA protein 10.4
TM7SF3 10.4
70kD) 10.4
DIA1 10.4
MURF2 10.3
NADH-ubiquinone reductase 10.1
NADH-coenzyme Q reductase 10.1
complex I) 10.0
SQM1 10.0
Core protein II 9.9
cytochrome c oxidase subunit 3 9.9
UQCRC1 9.8
RAD23 homolog B 9.8
hemoglobin alpha 2 9.8
ATP6V0A1 9.8
zinc finger protein 165 9.8
karyopherin beta 1 9.8
MTND3 9.8
Glutathione S-transferase kappa 1 9.8
MT-ND2 9.7
Fas-activated serine/threonine kinase 9.7
LEP503 9.6
SRP40 9.6
nucleotide binding protein-like 9.6
ubiquinol-cytochrome c reductase complex 9.6
neuronal tropomodulin 9.6
Nucleoside diphosphokinase 9.6
ATP synthase F0 subunit 6 9.6
CaM-KIIN 9.6
NADH2 9.6
ATPase subunit 6 9.5
Malic dehydrogenase 9.5
brain mitochondrial carrier protein-1 9.4
NADH cytochrome b5 reductase 9.4
COQ8 9.4
Multidrug resistance protein 3 9.4
URF2 9.4
NDUFB5 9.4
RAB-14 9.4
NADH dehydrogenase subunit 4L 9.4
tubulin alpha chain 9.4
more...
Disease
Brisket disease 10.8
nanophyetiasis 9.6
Chromophobe cell renal carcinoma 9.2
SCA28 8.1
vitamin B deficiency 7.9
Pyridoxine deficiency 7.6
DTD 7.3
Chloracne 7.3
Lissauer 7.3
Bordetella infection 7.3
PPPP 7.2
Persistent pulmonary hypertension 7.0
mitochondrial myopathy 7.0
SPG20 7.0
DIA 6.9
Reflux nephropathy 6.9
EBSS 6.8
mitochondrial encephalomyopathy 6.8
Diabetic encephalopathy 6.7
Complex I deficiency 6.5
RCA1 6.5
Leber's hereditary optic neuropathy 6.4
Leigh syndrome 6.3
FCU 6.2
pediatric disorder 6.2
CGD 6.2
Ileum 6.2
disorders of amino acid metabolism 6.1
erythrasma 6.1
SPG7 6.1
stage I breast cancer 6.0
NDI 6.0
Echinococcus granulosus infection 6.0
White Spot 6.0
coenurosis 5.8
cardiosclerosis 5.8
Microangiopathy 5.8
CBS deficiency 5.7
marijuana abuse 5.7
Klebs 5.6
Cogan 5.6
hereditary sensory neuropathy 5.6
Chronic progressive external ophthalmoplegia 5.6
MELAS 5.5
Barth syndrome 5.4
methemoglobinemia 5.4
favism 5.4
Hepatocarcinogenesis 5.4
MELAS 5.2
riboflavin deficiency 5.2
keratocyst 5.2
SGS 5.2
Retinal ischemia 5.2
Optic neuropathy 5.1
lymphoblastoma 5.1
Kearns-Sayre syndrome 5.1
alcoholic cardiomyopathy 5.0
Spinal cord ischemia 5.0
Thyroid gland 4.9
mitochondrial disease 4.9
SGS 4.8
coprophagy 4.8
enzyme deficiency 4.8
Choroid 4.8
Choroid 4.8
lactic acidosis 4.8
PAPA 4.7
Diaz 4.7
MERRF 4.7
Dicrocoelium dendriticum 4.7
diabetic hyperglycemia 4.5
acrocyanosis 4.5
liver infection 4.5
SM1 4.4
PCC 4.4
Worms 4.4
GHD 4.4
HBD 4.3
MIN 4.3
MIN 4.3
more...
Symptom
Respiration stimulated 11.4
ACHE 4.5
Decreased activity 4.3
ketonuria 4.3
ophthalmoplegia 4.0
hyperoxia 3.5
eds 3.3
hypotonia 3.3
drooling 3.0
incoordination 2.6
clubbing 2.6
orofacial pain 2.5
muscle rigidity 2.3
urinary frequency 2.3
abnormal gait 2.3
nasal congestion 2.2
cerebellar ataxia 2.2
muscle stiffness 2.1
hypertonia 2.1
cyanosis 2.1
dysarthria 2.1
pallor 2.1
chronic constipation 2.1
tonic-clonic seizure 2.0
anosmia 1.8
starvation 1.8
dystonia 1.7
lethargy 1.5
hepatomegaly 1.5
twitching 1.4
chorea 1.4
myoclonus 1.3
functional recovery 1.3
weakness 1.2
tachypnea 1.1
paraparesis 1.0
collapse 0.9
paresis 0.9
HSA 0.8
ataxia 0.8
exertional dyspnea 0.7
exhaustion 0.7
memory loss 0.6
fatigue 0.5
hemiplegia 0.4
acute stress 0.2
respiratory distress 0.1
constipation 0.1
seizures 0.0
hypothermia -0.1
hemoptysis -0.2
anesthesia -0.2
tremor -0.2
flushing -0.2
spasticity -0.3
myalgia -0.3
anorexia -0.4
arthralgia -0.4
acidity -0.5
hypercapnia -0.6
analgesia -0.8
thinning -1.1
agitation -1.2
sleepiness -1.2
stigma -1.3
pain -1.4
vomiting -1.6
nausea -2.1
dyspnea -2.4
headache -2.4
diarrhea -3.4
Drug
Juvela 11.4
Nanaomycin D 10.8
Cocarboxylase 9.6
Duroquinone 8.8
NADH 8.8
Tuareg 7.8
FAD 7.6
URF 7.5
Diethylpropion 7.4
Pegaspargase 7.2
Naftidrofuryl 7.1
Secobarbital 7.1
Idebenone 7.1
Demerol 7.0
Flavin 6.6
Atabrine 6.5
Demerol 6.4
Dodecyl Sulfate 6.2
Chlorate 6.2
Cicletanine 6.0
Cibacron Blue 5.8
Sodium thiosulfate 5.8
Palmitoyl 5.8
Malonaldehyde 5.8
Doxapram 5.8
Clofibrate 5.6
Photofrin II 5.4
Vanilla 5.3
NBT 5.2
Trifluoperazine 5.2
Abamectin 5.2
Vitamin K 5.1
Fenbendazole 5.1
Atovaquone 5.0
Vardenafil 5.0
SMP 4.8
Isoniazid 4.8
AGG 4.8
Novantrone 4.8
Aminoguanidine 4.7
Ethylenediamine 4.6
Atovaquone 4.6
Cytidine 4.5
Miltefosine 4.5
Asparaginase 4.4
Geranium 4.4
Bezafibrate 4.3
ascorbate 4.2
Kainic acid 4.1
Nitric Oxide 4.1
Dexon 4.0
Glutathione 3.8
Riboflavin 3.8
all-trans-retinol 3.8
Bosentan 3.7
Bosentan 3.7
Photofrin 3.6
DFP 3.5
Emodin 3.5
Fructose 3.5
Monensin 3.5
Sodium nitroprusside 3.5
EHDP 3.4
ROS 3.4
AZT 3.3
Vitamin E 3.3
CPR 3.3
GHRP 3.3
Captopril 3.2
Ethanol 3.2
Emodin 3.2
citric acid 3.2
Adriamycin 3.2
Metrizamide 3.2
linolenate 3.2
AZT 3.2
Apomorphine 3.1
Parkin 3.1
Parkin 3.1
Methylene blue 3.1
more...
Enzyme
diaphorase 12.4
malate-lactate transhydrogenase 12.4
4NQO reductase 12.4
NADH dehydrogenase 12.3
diaphorase 11.9
asparagusate dehydrogenase 11.4
NADPH-diaphorase 11.4
CPR 10.9
EC 3.2.1.70 10.8
NQO1 10.7
EC 1.1.1.108 10.4
complex I 10.4
aquacobalamin reductase 10.2
12alpha-hydroxysteroid dehydrogenase 10.1
methylviologen-reducing hydrogenase 10.1
malate oxidase 9.7
ubiquinol-cytochrome c oxidoreductase 9.6
D-sorbitol dehydrogenase 9.5
EC 1.1.99.16 9.4
4-N-trimethylaminobutyraldehyde dehydrogenase 9.2
bidirectional hydrogenase 9.1
ferric leghemoglobin reductase 9.1
DHOdehase 9.0
NADH-cytochrome b5 reductase 9.0
NAD+ synthetase 8.9
benzoate dioxygenase 8.8
4-hydroxyproline 2-epimerase 8.8
adrenodoxin reductase 8.7
3beta-HSDH 8.6
4-hydroxybutyrate dehydrogenase 8.4
CMP-sialic acid:lactosylceramide sialyltransferase 8.4
glutaconyl-CoA decarboxylase 8.4
p-hydroxyphenylacetate 3-hydroxylase 8.3
sucrose-phosphatase 8.2
transhydrogenase 8.2
succinate dehydrogenase 8.2
succinic dehydrogenase 8.2
nicotinic acid hydroxylase 8.1
beta-hydroxybutyrate dehydrogenase 8.1
glutathione oxidase 8.1
acylcarnitine hydrolase 8.0
D-galactose dehydrogenase 8.0
6-phosphogluconate dehydratase 8.0
thiosulfate dehydrogenase 8.0
KGOR 7.9
dihydrodipicolinate reductase 7.8
allantoate amidohydrolase 7.8
hydroxylamine oxidase 7.8
cytochrome oxidase 7.7
LTB4 omega-hydroxylase 7.7
ADP-dependent glucokinase 7.7
thiosulfate dehydrogenase 7.6
chorismate synthase 7.6
GDPase 7.6
fumarate reductase 7.5
malate dehydrogenase 7.5
flavin reductase 7.5
lactic acid dehydrogenase 7.4
methylmalonyl-CoA epimerase 7.4
EC 1.1.1.47 7.4
vanillyl-alcohol oxidase 7.4
glycerol-3-phosphate dehydrogenase 7.4
SsuE 7.4
D-dopachrome tautomerase 7.4
glycerol-3-phosphate dehydrogenase 7.4
lactic acid dehydrogenase 7.4
hydroxyprostaglandin dehydrogenase 7.4
aryl hydrocarbon hydroxylase 7.3
ADPase 7.3
glycerol-3-phosphate oxidase 7.3
L-amino-acid oxidase 7.2
nicotinamide adenine dinucleotide glycohydrolase 7.1
mannitol 1-phosphate dehydrogenase 7.1
EC 1.1.1.39 7.0
demethylase 7.0
NAD+ kinase 7.0
membrane-bound hydrogenase 7.0
butyryl-CoA dehydrogenase 7.0
ecdysone 20-monooxygenase 6.9
alpha-ketoglutarate dehydrogenase 6.9
more...
Compound
Optochin hydrochloride 12.4
Adriamycin aglycone 12.4
S-Methylisothiourea sulfate 12.4
Ubisemiquinone 11.4
Asparagusate 11.4
Bis(p-bromophenyl) ether 11.4
1-bromoheptane 11.0
Hyponitrite 10.8
undecylbenzene 10.4
Rifamycin S 10.4
Syrosingopine 10.4
CB 1954 10.3
Xanthomegnin 10.1
spirost-5-en-3-ol 10.1
Funiculosin 10.1
ubiquinol 9.9
Succinic acid monomethyl ester 9.8
Stigmatellin 9.8
Trichloropropene oxide 9.8
Tirandamycin 9.8
Diphenyliodonium chloride 9.6
TNBT 9.5
Nitromin 9.4
CoQ6 9.3
D-Carnitine 9.2
Sinulariolide 9.2
1,2,3-benzothiadiazole 9.1
Quinalizarin 8.9
5-Methoxyindole 8.8
2-hydroxynaphthoquinone 8.8
NADH 8.8
Pyrrolnitrin 8.8
Coproporphyrin III 8.7
2-hydroxynaphthoquinone 8.7
3-succinoylpyridine 8.6
Cytochrome c1 8.6
2,2',5,5'-TCB 8.5
dihydrolipoamide 8.4
Ferricyanide 8.4
Coproporphyrin III 8.4
FMNH 8.4
Propylhexedrine 8.4
Ethylmorphine 8.3
2,6-dichlorophenol 8.3
Ferredoxin 8.3
Duroquinone 8.3
Ametantrone 8.3
L-Histidinol 8.3
nicotinamide 8.3
2,2,4-trimethyl-1,2-dihydroquinoline 8.2
Diphenyl ether 8.2
Methacrylonitrile 8.2
Antimycin 8.2
p-Nitrobenzoic acid 8.1
Actinorhodin 8.1
ubiquinone 8.1
Nitroethane 8.1
Paraxanthine 8.1
NMOR 8.0
D-Proline 8.0
7-Ethoxycoumarin 8.0
DCIP 8.0
L-dopachrome 7.9
Diethylpropion 7.9
FMN 7.9
NADPH 7.9
NADPH 7.9
Fe(CN)3 7.8
Coumarin 7 7.8
3-mercapto-1,2-propanediol 7.8
Spartin 7.8
Mono-n-butyl phthalate 7.8
Nitrofuran 7.8
Coumarin 7 7.8
Sedoheptulose 7.8
p-Nitroanisole 7.8
Glyceollin 7.7
Glyceollin 7.7
Hexobarbital 7.7
1,3-Dinitrobenzene 7.6
more...