Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.3 (diaphorase)
 5,903 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-seven blood enzymes and proteins, whose structures are presumably controlled by at least 33 genes, were assayed in Arctic and silver foxes by starch gel electrophoresis. Two types of protein and enzyme electrophoretic patterns were distinguished: one exhibiting a single enzyme, the other several isozymes. The two fox species were found to differ in seven of the 27 enzymes and proteins studied: glucose-6-phosphate dehydrogenase, adenylate kinase, erythrocyte carboxylesterase, diaphorase, prealbumin, transferrin, and albumin. No differences were established between the species for the other enzymes and proteins. The data are interpreted as evidence for the existance of a set of enzymes and proteins differentiating the Arctic from the silver fox.
 ...
PMID:Allelic expression in intergeneric fox hybrids (Alopex lagopus x Vulpes vulpes). I. Comparative electrophoretic studies on blood enzymes and proteins in arctic and silver foxes. 101 23

A comparative study of 27 enzymes and proteins in blue and silver foxes was carried out by means of starch gel electrophoresis. The structure of these enzymes and proteins is determined by about 33 genes. It is shown that a number of blood enzymes and proteins of these species is represented by a single electrophoretic form, while lactate dehydrogenase, carboanhydrase, arylesterase, carboxylesterase, diaphorase, hexokinase and tetrasolium oxidase have several forms. It is also found that these species differ in seven enzymes and proteins: diaphorase, G-6-PD, adenylate kinase, carboxylesterase, albumin, prealbumin, transferrins. Other enzymes and proteins are similar in their electrophoretic mobility. The data obtained afford the evidence that the two species (Vulpes vulpes and Alopex lagopus) differ in a set of enzymes and proteins.
 ...
PMID:[Homologous gene expression in intergeneric fox hybrids (Alopex lagopus x Vulpes vulpes). I. Comparative electrophoretic analysis of blood proteins and enzymes in Arctic and silver foxes]. 121 28

The effect of a 20-day administration of aminopyrine (600 mg kg-1) as well as two metabolites of aminopyrine, 4-aminoantipyrine (525 mg kg-1) and 4-acetamidoantipyrine (635 mg kg-1), on several hepatic, kidney and serum enzyme activities were investigated. In the aminopyrine-treated group, a pronounced induction of gamma-glutamyl transpeptidase was shown in the whole homogenate as compared to that in the hepatic microsomes. Serum gamma-glutamyl transpeptidase activity was also increased by administration of aminopyrine or 4-aminoantipyrine. No change in gamma-glutamyl transpeptidase activity was observed in kidney and hepatic cytosolic fractions. In all cases, 4-acetamidoantipyrine treatment showed no significant change in the enzyme activities tested. Under the same experimental condition, the amounts of cytochrome P-450 and b5, the activities of aminopyrine N-demethylase, aniline hydroxylase and carboxylesterase of liver microsomes were all induced in the aminopyrine- and 4-aminoantipyrine-treated rats. The activities of NADPH cytochrome c reductase and NADH ferricyanide reductase were also increased. The results in this paper support the view that repeated administration of aminopyrine induces hepatic membrane-bound enzyme, particularly, gamma-glutamyl transpeptidase activity.
 ...
PMID:Induction of hepatic gamma-glutamyl transpeptidase in rats by repeated administration of aminopyrine. 612 88