Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.6.99.3 (diaphorase)
 5,903 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sprague-Dawley rats were fed a synthetic diet deficient in or containing thiamin (20 mcg/gm food), riboflavin (50 mcg/gm), or pyridoxine (50 mcg/gm) while receiving either norethindrone (1.0 or 10.0 mg/rat/day) or methocel solution to determine the influence of this oral contraceptive on drug-metabolizing enzymes of female rat liver. Ingestion of high levels of thiamin significantly decreased the activity of cytochrome P-450, NADPH cytochrome c reductase, and the metabolism of aniline and ethylmorphine. Diets containing riboflavin significantly depressed V max for aniline hydroxylation and ethylmorphine demethylation while NADPH cytochrome c reductase was elevated. V max for aniline hydroxylase was the only drug-metabolizing enzyme which was affected by high levels of dietary pyridoxine. Norethindrone slightly depressed or left unaffected the activity of cytochrome P-450 regardless of diet. Norethindrone increased activity of c reductase and ethylmorphine N-demethylase or left it unchanged. Norethindrone induces aniline hydroxylase in all diets except those deficient in thiamin and riboflavin. The effects of norethindrone on the kinetics of aniline metabolism were unexplained by substrate enzyme-binding kinetics. However, it is apparent that dietary status affects the parameters studied and the effects of norethindrone.
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PMID:Influence of norethindrone on drug-metabolizing enzymes of female rat liver in various B-vitamin deficiency states. 40 27