Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.3 (diaphorase)
 5,903 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Young rats were exposed to 2, 5, 8 and 10 Gy 50 kV local irradiation. The epiphyseal region of the proximal tibia was examined with histopathologic, histochemical and enzyme histochemical methods 1 to 90 days after irradiation. One day after irradiation, a decrease in alkaline phosphatase activity was noted and increased activity was found for acid phosphatase, NADH2-diaphorase and glucose-6-phosphate dehydrogenase, especially after 8 and 10 Gy, but also after 5 Gy. Three days after irradiation, all enzymes showed an increased activity and on day 7 the findings resembled those on day 3. Thirty days after irradiation, a return to normal conditions was observed. The most marked morphologic changes were swelling of cells in the hypertrophic cell zone, disturbed order of cells in the zone of proliferation and an increased number of osteoclasts in the metaphyseal bone. These alterations appeared 1 to 3 days after irradiation and normal morphology was seen on day 30 after 2, 5 and 8 Gy and 90 days after irradiation with 10 Gy.
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PMID:Effect of 50 kV irradiation on enzyme activities of growing rat bone. A histopathologic and enzyme histochemical investigation. 630 36

The activities of NADH2-diaphorase, leucine aminopeptidase, and acid phosphatase were studied histochemically in spermatozoa and seminal plasma of 28 ejaculates from 13 men with proven fertility and in 31 ejaculates from 29 men living in infertile marriages. The enzyme activities were correlated with the spermiogram. The NADH2-diaphorase activity was located exclusively in the midpiece of the spermatozoa, while the activities of leucine aminopeptidase and acid phosphatase seemed to be located only on the surface. A positive correlation was found between the NADH2-diaphorase activity and the spermatozoal motility, density, and morphology.
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PMID:Enzyme histochemical studies of human spermatozoa correlated with the spermiogram. 689 11

The histochemical, enzyme-histochemical and ultrastructural characteristics of the adipocyte precursors in human embryos at 6-12 weeks of gestation were studied. Some consequent stages in the histogenesis and differentiation of the fat cells were maintained according to: 1/number and size of the lipid droplets; 2/position of the nucleus. The cells become rounder, accumulate lipid inclusions, acquire eccentric nucleus, gradually gather in clusters. No typical unilocular adipocytes were seen at this stage of fetal development. The enzyme-histochemistry disclosed that the reactions for glucose-6P-dehydrogenase, NADH2 diaphorase and especially lipoprotein lipase were highly expressed. Ultrastructurally the adipocyte precursors were with a great amount of organelles/mitochondria of typical sight, well developed rough and smooth endoplasmatic reticulum/, lipid droplets and glycogen which express their high functional activity. This study could provide criteria for understanding the processes of lipidogenesis and differentiation.
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PMID:Histochemical and ultrastructural criteria for early differentiation of human subcutaneous adipocytes. 1020 88

EDS alkylating agent has been shown to selectively and temporarily kill LCs in adult rats. The first newly formed single LCs appeared at 14th day post ESD and showed detectable activity for 3beta-HSD and NADH2-diaphorase, which became progressively stronger with time after treatment The ultrastructural study revealed that the progenitor LCs differentiated into immature LCs within a week, and two weeks later they were transformed into mature LCs. Therefore, the restoration of new LC population after EDS treatment repeated the dynamics of normal LC development within a similar time range. The dynamics of enzyme activity correlated with structural differentiation of the new LC population.
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PMID:Steroidogenic and structural differentiation of new Leydig cell population following exposure of adult rats to ethane dimethanesulphonate. 1244 69


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