Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.6.99.3 (diaphorase)
 5,903 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of chronic adriamycin treatment on cellular defence mechanisms against free radicals has been determined in rats. To that end, the changes in vitamin E content, activity of superoxide dismutase, catalase and factors of the glutathione system were measured in heart, kidneys and liver after 24 and 52 days of treatment. Moreover, damage was assessed by measuring the activity of NADPH- and NADH-cytochrome c reductase. The results concerning the components of the oxidative defence systems in male rats showed reductions in the activity of superoxide dismutase and catalase in renal tissue and in factors of the glutathione system in liver tissue. In cardiac tissue an increased activity of catalase and elevated content of total glutathione were found. Vitamin E content was increased in liver and to a lesser extent, in kidneys. The activity of Se-dependent glutathione peroxidase sharply decreased only in liver. Major differences between male and female rats were not observed in renal and cardiac tissue, as far as protective factors were concerned. However, a decrease in catalase activity was detectable earlier in male kidneys. The protective factors in liver of female rats were far less susceptible to in vivo treatment with adriamycin, as compared to liver of male rats. Decreased activity of the cytochrome reductases was found in liver of male rats. In male renal tissue only cytochrome c reductase activity was significantly reduced. Male cardiac tissue showed no signs of biochemical damage, although from histological examination in a parallel study [J Natl Cancer Inst 76: 299-307 (1986)] lesions were evident. In female rats no damage was found in liver, kidneys and heart.
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PMID:The effect of chronic adriamycin treatment on heart kidney and liver tissue of male and female rat. 337 82

The investigation was carried out on 86 white non-inbred male rats. Hypokinesia was produced by putting the animals into pencil-boxes for 1,2 and 4 weeks. The changes in specific volumes of various hepatic microvessels under hypokinesia and under hypokinesia combined with metyrapone administration were studied sterologically. NAD-diaphorase activity in hepatocytes and in the interlobular connective tissue was estimated photometrically. hypokinesia produces certain changes in the specific volume of all the hepatic microvessels studied, but the degree and character of the volumetric relations revealed between these microvessels are different. At metyrapone administration, the volumetric changes in various microvessels occur with greater regularity. The changes in NAD-diaphorase activity under the same conditions occur slower and by the end of the experiment the enzymatic activity returns to the initial level.
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PMID:[Functional and morphological characteristics of rat liver microvessels in hypokinesia]. 709 90