Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.6.99.3 (diaphorase)
 5,903 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A male with mitochondrial myopathy, encephalopathy, lactic acidemia, and strokelike episodes is reported. He had also recurrent episodes of ileus. Muscle biopsy revealed ragged-red fibres. The cytochemistry of cytochrome c oxidase (CCO) showed scattered nonstained fibres, while all muscle fibres were heavily stained by immunocytochemistry using CCO antibody. These findings suggest that partical CCO deficiency may be present in the skeletal muscles of the patient. NADH cytochrome c reductase in the patient's muscle mitochondria was low compared with normal controls (about 26%), although succinate cytochrome c reductase was normal. Coenzyme Q10 administration (90 mg/day) did not improve CSF lactate levels, but did decrease plasma lactate levels. His muscle weakness slightly improved.
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PMID:Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes with recurrent abdominal symptoms and coenzyme Q10 administration. 282 4

Content of cytochromes P-450 and b5 as well as activities of amidopyrine demethylase, aniline hydroxylase and NADPH cytochrome c reductase were studied in liver tissue of rats with occlusive and strangulational ileus. Distinct inhibition of main microsomal enzymes activity and decrease of cytochromes content in hepatocytes occurred independently on the type of acute intestinal obstruction. Within early periods after surgical operation of the acute intestinal obstruction all the alterations observed were maintained especially distinctly in the strangulational type of the disease.
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PMID:[State of the microsomal oxidative system of the rat liver in acute intestinal obstruction]. 342 Jul 99