Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.1 (NADPH-diaphorase)
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Human Gene/Protein
nitric oxide synthase 2055
diaphorase 1890
NADPH 952
NADH 477
neuronal nitric oxide synthase 278
Sep 248
NAD 228
reductase 182
acetylcholinesterase 143
olfactory 129
tyrosine hydroxylase 125
NADP 120
substance P 120
neuropeptide Y 118
Mol 114
choline acetyltransferase 110
somatostatin 104
oxidoreductase 102
inducible nitric oxide synthase 102
calbindin 101
polypeptide 93
calcitonin 84
ferredoxin 81
axonal 80
FAD 77
lactate dehydrogenase 76
superoxide dismutase 76
parvalbumin 75
endoplasmic reticulum 68
cytochrome c 67
glucose-6-phosphate dehydrogenase 66
calretinin 64
flavoprotein 63
GABA 62
CA1 61
peroxidase 60
ATP 60
alkaline phosphatase 59
acid phosphatase 56
vasoactive intestinal peptide 53
gut 52
NAD+ 52
NADP+ 51
FMN 50
glial fibrillary acidic protein 49
guanylate cyclase 46
eNOS 45
catalase 44
calmodulin 42
microsomal 41
vasoactive intestinal peptide (VIP) 40
cytochrome 40
DT-diaphorase 39
galanin 39
ATPase 38
soluble guanylyl cyclase 38
lipoamide dehydrogenase 37
CA3 35
GSH 35
NMDA receptor 34
Diaphorase 34
vasopressin 33
NADH diaphorase 32
vascular endothelium 32
glutathione reductase 32
esterase 32
lipopolysaccharide 31
endothelial nitric oxide synthase 28
constitutive nitric oxide synthase 27
glutathione peroxidase 26
NADH dehydrogenase 25
membrane-bound 24
oxytocin 24
xanthine oxidase 23
c-fos 23
PCC 22
malate dehydrogenase 22
NADH2 22
glucose-6-phosphatase 21
alcohol dehydrogenase 21
more...
Disease
NAME 121
Huntington's disease 63
ischemia 52
cancer 48
diabetes 46
varices 39
Alzheimer's disease 37
GSH 35
tumor 33
hypertension 31
pheochromocytoma 22
PCC 22
Parkinson's disease 20
SDS 19
uterus 18
depression 18
heart failure 15
urethra 14
carcinogenesis 14
schizophrenia 13
cholera 13
hepatocellular carcinoma 12
epilepsy 12
cold 12
cerebral ischemia 11
amyotrophic lateral sclerosis 10
erectile dysfunction 10
neuroblastoma 10
dehydration 10
atherosclerosis 9
stroke 9
melanoma 9
Chagas 9
carcinoma 8
mole 8
Lissauer 8
breast cancer 8
mole 8
dysplasia 8
DIA 7
epididymis 7
ureter 7
celiac disease 7
methemoglobinemia 7
vagina 7
Mycobacterium 6
obesity 6
asthma 6
hyperglycemia 6
encephalopathy 6
Choroid 6
malnutrition 6
SEM 6
pulmonary hypertension 6
Choroid 6
chronic granulomatous disease 6
cholestasis 5
status epilepticus 5
fits 5
impotence 5
tuberculosis 5
SCH 5
Evans 5
cirrhosis 5
herpes simplex 5
paraplegia 5
achalasia 5
ulcerative colitis 5
DBA 5
sepsis 4
multiple sclerosis 4
Crohn's disease 4
worms 4
intraocular pressure 4
movement disorder 4
dementia 4
pertussis 4
Pancreas 4
disinhibition 4
uterine cervix 4
more...
Symptom
pain 39
seizures 25
anesthesia 24
fatigue 9
functional recovery 8
analgesia 7
weakness 4
myalgia 4
hypothermia 4
starvation 4
constipation 4
tremor 3
respiratory distress 3
headache 3
Neuropathic pain 3
Deafferentation 2
twitching 2
spasticity 2
ataxia 2
pallor 2
anorexia 2
Decreased activity 2
eds 2
dystonia 2
incoordination 2
vomiting 2
Macula 2
arthralgia 2
thinning 2
sleepiness 2
memory loss 1
collapse 1
overweight 1
polyuria 1
syncope 1
stigma 1
sciatica 1
tonic-clonic seizure 1
hemoptysis 1
splenomegaly 1
acute pain 1
hypotonia 1
insomnia 1
acidity 1
nasal congestion 1
nausea 1
ACHE 1
urinary frequency 1
hepatomegaly 1
agitation 1
distraction 1
neuralgia 1
clonus 1
chronic constipation 1
back pain 1
ophthalmoplegia 1
cyanosis 1
abnormal gait 1
cerebellar ataxia 1
spasm 1
hypercapnia 1
lethargy 1
diarrhea 1
paresthesia 1
orofacial pain 1
exhaustion 1
ketonuria 1
Gasping 1
anosmia 1
acute stress 1
tachypnea 1
dyspnea 1
dyschezia 1
Drug
NADH 509
FAD 77
Nitric Oxide 21
ascorbate 17
NBT 13
lysine 9
Kainic acid 9
Sodium nitroprusside 9
Ethanol 7
nitroglycerin 7
Glutathione 7
Cardiovasc 6
Gel 6
Vitamin K 5
Heme 5
Methylene blue 5
ROS 5
caffeine 5
vitamin E 4
Nephron 4
Captopril 4
Atropine 3
HCH 3
EE2 3
IFN-gamma 3
Clonidine 3
L-tyrosine 3
Pentaerythritol tetranitrate 3
PCP 3
Dermatol 3
MAP 3
DFP 2
Glycerol 2
ALA 2
Ouabain 2
G418 2
citric acid 2
CET 2
CTX 2
niacin 2
pyridoxal phosphate 2
Riboflavin 2
Indomethacin 2
Cibacron Blue 2
ABC 2
CSF 2
Retinoic acid 2
Trifluoperazine 2
Bifidobacterium 2
Apomorphine 2
Idebenone 1
AZT 1
Guanethidine 1
Simvastatin 1
Histamine 1
Vardenafil 1
PTC 1
Ethylenediamine 1
Reserpine 1
Asn 1
Vitamin E 1
Atabrine 1
Orlistat 1
Growth hormone 1
Adriamycin 1
Fenbendazole 1
7-Nitroindazole 1
Aminoguanidine 1
Taxol 1
PFA 1
Ginseng 1
Amiloride 1
Amiloride 1
Growth hormone 1
lactose 1
BH4 1
OMP 1
GHRP 1
Dial 1
Duroquinone 1
more...
Enzyme
NADPH-diaphorase 3903
diaphorase 1920
NQO1 1903
diaphorase 1893
NO synthase 1564
NOS 211
NADPH oxidase 144
acetylcholinesterase 141
tyrosine hydroxylase 119
choline acetyltransferase 110
succinate dehydrogenase 92
lactate dehydrogenase 91
superoxide dismutase 82
glucose-6-phosphate dehydrogenase 78
peroxidase 74
guanylate cyclase 65
cytochrome oxidase 63
alkaline phosphatase 60
ATPase 59
acid phosphatase 57
CPR 55
catalase 46
adrenodoxin reductase 39
complex I 37
glutathione reductase 33
malate dehydrogenase 31
succinic dehydrogenase 30
nitrate reductase 29
hydrogenase 28
glutathione peroxidase 28
hydrogenase 28
NADPH oxidase 28
NADH dehydrogenase 25
nitrate reductase 24
nitrate reductase 24
nitrate reductase 24
nitrate reductase 24
nitrate reductase 24
alcohol dehydrogenase 24
glycerol-3-phosphate dehydrogenase 22
glycerol-3-phosphate dehydrogenase 22
xanthine oxidase 21
glucose-6-phosphatase 21
glutamate dehydrogenase 20
glutamate dehydrogenase 19
glutamate dehydrogenase 19
transhydrogenase 17
NADH-cytochrome b5 reductase 16
phosphodiesterase 16
isocitrate dehydrogenase 16
beta-hydroxybutyrate dehydrogenase 14
nitrite reductase 13
nitrite reductase 13
nitrite reductase 13
glucose dehydrogenase 13
monoamine oxidase 13
hexokinase 13
phosphorylase 13
heme oxygenase 13
isocitrate dehydrogenase 13
cholinesterase 13
glutathione S-transferase 12
renin 12
protochlorophyllide oxidoreductase 12
gamma-glutamyl transpeptidase 10
reverse transcriptase 10
6-phosphogluconate dehydrogenase 10
protein kinase 10
6-phosphogluconate dehydrogenase 10
HSD 10
argininosuccinate synthetase 9
thioredoxin reductase 9
aspartate aminotransferase 9
leucine aminopeptidase 9
lipase 8
pyruvate dehydrogenase 8
lactic acid dehydrogenase 8
glutamate decarboxylase 8
argininosuccinate lyase 8
trypsin 8
more...
Compound
nitric oxide 1346
NADPH 958
NADPH 957
nicotinamide 814
phosphate 803
NADH 506
arginine 387
Dec 306
NAD 284
NADP 241
NAD 228
oxygen 166
calcium 147
sodium 147
cGMP 123
glutamate 95
water 94
glucose 90
hydrogen 82
FAD 78
DNA 71
salt 67
GABA 63
GABA 62
ATP 60
Clin 54
Neuronal 53
CIT 51
FMN 51
iron 49
nitrate 46
ethanol 42
GSH 39
nitrogen 39
GSH 39
sulfate 38
CO2 35
5-HT 34
NMDA 32
pyridine 31
acetate 31
GMP 27
H2O2 27
potassium 27
gamma-aminobutyric acid 27
silver 27
formaldehyde 26
tyrosine 25
formaldehyde 24
His 23
cyanide 23
cysteine 23
alcohol dehydrogenase 22
fluorine 22
aldehyde 22
Ferredoxin 21
naphthoquinone 20
SDS 20
naphthoquinone 20
ammonium 20
naphthoquinone 20
naphthoquinone 20
ACh 20
naphthoquinone 20
naphthoquinone 20
copper 20
ADP 20
naphthoquinone 20
methionine 19
EDTA 18
ADP 18
Triton X-100 18
ADP 18
noradrenaline 17
glucose-6-phosphate 17
aldehyde 17
EDTA 17
NBT 16
leucine 16
Substance P 15
more...