Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.1 (NADPH-diaphorase)
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Human Gene/Protein
CGI-49 13.0
diaphorase 13.0
Diaphorase 11.9
GPRg1 11.4
70kD) 11.0
protein inhibitor of neuronal nitric oxide synthase 10.8
DIA1 10.4
NADH diaphorase 10.3
neuronal tropomodulin 10.2
MAMDC2 10.2
Malic dehydrogenase 10.1
NADH2 10.0
PR65A 10.0
GluR4c 9.8
STARD6 9.7
collagen alpha-2 9.7
aflatoxin B1-aldehyde reductase 9.7
LC8a 9.5
heat shock protein beta 9.4
ASAL 9.3
annexin A8 9.3
Argininosuccinate synthetase 9.2
ATP synthase F0 subunit 6 9.2
Constitutive NOS 9.2
PGR5 9.2
NADPH2 9.2
nitric oxide synthase 9.1
neuronal nitric oxide synthase 9.0
lipoamide 8.9
KGDHC 8.9
tubulin beta chain 8.8
NMO1 8.8
QR1 8.8
TALH 8.7
REM1 8.7
DLDH 8.6
flavin reductase 8.6
A. nidulans) 8.5
NOS III 8.5
DARP 8.5
receptor activity modifying protein 2 8.5
Succinic dehydrogenase 8.4
NOS-1 8.4
steroid dehydrogenase-like protein 8.4
NADH-coenzyme Q reductase 8.4
NAP4 8.4
MAPK4 8.4
ECA39 8.4
ADCY8 8.4
constitutive nitric oxide synthase 8.3
Signal transducer and activator of transcription 4 8.3
TSA2 8.3
NADPH 8.3
lipoamide dehydrogenase 8.3
progesterone receptor membrane component 2 8.2
cadherin-8 8.2
N-acetylmuramoyl-l-alanine amidase 8.2
S3-12 8.1
keratin 12 8.1
NCAM2 8.1
Dia2 8.0
ENC1 8.0
FIT2 7.9
DTD 7.8
PSPH 7.8
putative oxidoreductase 7.8
MINOR 7.7
3alpha-HSD 7.7
D-lactate dehydrogenase 7.7
CYB5R3 7.7
calbindin 7.6
FADH2 7.5
DIA 7.5
ISP2 7.5
Microtubule-associated protein 1A 7.5
E25 7.5
MT-ND2 7.5
ATP synthase subunit beta 7.5
VK3 7.5
NADH 7.5
FMN 7.5
stumpy 7.4
soluble guanylyl cyclase 7.4
SETA 7.4
kynurenine 3-hydroxylase 7.4
calretinin 7.4
flavoprotein 7.3
PSAT1 7.3
DT-diaphorase 7.3
B4GALT1 7.3
NADP+ 7.2
RNO 7.2
PGP 9.5 7.2
limbic system-associated membrane protein 7.2
isocitric dehydrogenase 7.2
choline acetyltransferase 7.2
NOS1 7.1
argininosuccinate lyase 7.1
ChAT 7.1
GPD 7.1
quinone reductase 7.1
NADP 7.1
EHD2 7.1
argininosuccinate synthetase 7.1
GRIM-19 7.0
HDH 7.0
D-dopachrome tautomerase 7.0
group-specific component 7.0
SGCA 7.0
SON 7.0
Peripherin 7.0
DCIP 7.0
POR 7.0
PLB 6.9
Microtubule-associated protein 2 6.9
mitochondrial transcription termination factor 6.9
isoform a 6.9
glutamate-cysteine ligase modifier subunit 6.9
Engrailed-2 6.9
UCK2 6.8
parvalbumin 6.8
FAD 6.8
C3-C5 6.8
ACSL3 6.8
TFB2M 6.8
TRX 6.8
nucleoside phosphorylase 6.8
FSP27 6.8
granulocyte chemotactic protein-2 6.7
ferredoxin 6.7
oxidoreductase 6.7
NOR1 6.7
Citron 6.7
EF1A 6.7
neuropeptide Y 6.7
NADH dehydrogenase 6.7
NAK 6.6
BBS 6.6
GluR4 6.6
UII 6.6
LDH-B 6.6
NQO1 protein 6.6
phosphoglycolate phosphatase 6.6
GCL 6.6
adrenodoxin reductase 6.5
NAD 6.5
kelch-like ECH-associated protein 1 6.5
FTH1 6.5
glucose dehydrogenase 6.5
SDH 6.5
H16 6.5
6PGD 6.5
Choline acetyltransferase 6.5
FOG 6.5
HDB 6.5
P57 6.5
vasoactive intestinal peptide 6.5
NMNAT 6.5
galanin 6.5
vasoactive intestinal peptide (VIP) 6.5
more...
Disease
Irreversible pulpitis 9.8
Distal colitis 9.2
Total colonic aganglionosis 8.8
vitamin B deficiency 8.5
Lissauer 8.3
Renal pelvis 8.2
Renal pelvis 8.2
Bordetella infection 7.9
AAT2 7.6
Persistent pulmonary hypertension 7.6
DIA 7.5
DTD 7.5
Reflux nephropathy 7.5
Klebs 7.2
Choroid 7.0
Choroid 7.0
AA2 6.8
CGD 6.8
Ileum 6.8
erythrasma 6.7
megarectum 6.7
stage I breast cancer 6.6
Spinal cord ischemia 6.6
cardiosclerosis 6.4
Goldblatt hypertension 6.4
Microangiopathy 6.4
CBS deficiency 6.3
NAME 6.2
TYPE 6.2
Chronic progressive external ophthalmoplegia 6.1
catatonic schizophrenia 6.1
favism 6.0
NCR 5.8
keratocyst 5.8
SGS 5.8
Retinal ischemia 5.8
Economo 5.7
lymphoblastoma 5.7
methemoglobinemia 5.7
alcoholic cardiomyopathy 5.6
AA1 5.6
SGS 5.4
PHS 5.4
PAPA 5.3
pulpitis 5.3
Huntington's disease 5.2
TNS 5.2
SWS 5.2
diabetic hyperglycemia 5.1
acrocyanosis 5.1
liver infection 5.1
Fallopian tube 5.0
vascular headache 5.0
GHD 5.0
HBD 4.9
PCC 4.9
Congenital hypothyroidism 4.9
Bardet-Biedl syndrome 4.9
varices 4.9
centronuclear myopathy 4.8
Zinc deficiency 4.8
nerve lesion 4.8
hyperosmolality 4.8
audiogenic seizure 4.7
myeloblastosis 4.6
ST8 4.6
enzyme deficiency 4.6
glutaric aciduria 4.6
cauda equina syndrome 4.6
spindle cell sarcoma 4.5
anal fissure 4.5
chronic rhinitis 4.5
SD1 4.5
cerebral thrombosis 4.4
DMC 4.4
nasal allergy 4.4
megacolon 4.4
nutritional disorder 4.4
anal atresia 4.3
Krabbe disease 4.3
Bezold 4.3
BCG infection 4.3
esophageal dysmotility 4.2
chronic granulomatous disease 4.2
MELAS 4.1
PNS 4.1
hypertensive encephalopathy 4.1
mastopathy 4.1
Fox 4.1
LMS 4.1
LMS 4.1
neonatal asphyxia 4.0
monoarthritis 4.0
EDA 4.0
cataplexy 4.0
achalasia 3.9
Optic nerve 3.8
MELAS 3.8
AIP 3.7
HYP 3.7
thiamine deficiency 3.7
ED2 3.7
uvea 3.7
NBS 3.7
AIP 3.7
abnormal involuntary movements 3.7
moderate mental retardation 3.7
Goldblatt 3.6
pheochromocytoma 3.6
Hymenolepis 3.6
urethra 3.6
chronic glomerulonephritis 3.6
methylmalonic acidemia 3.6
Ischemic stroke 3.6
erectile dysfunction 3.6
PNET 3.5
HEP 3.5
impotence 3.5
multi-infarct dementia 3.4
lipidosis 3.4
PDR 3.4
PMS 3.4
Goldstein 3.4
galactosemia 3.3
AMN 3.3
trypanosomiasis 3.3
Benson 3.3
arachnoiditis 3.3
nephrosclerosis 3.3
GAD 3.3
SWS 3.3
MSA 3.3
generalized seizure 3.3
parakeratosis 3.3
antidiuresis 3.2
MDI 3.2
diabetic neuropathy 3.2
sensory neuropathy 3.2
renal hypertension 3.2
hyperoxaluria 3.2
vitamin E deficiency 3.2
brain dysfunction 3.1
ischemic colitis 3.1
leukodystrophy 3.1
HCA 3.1
homocystinuria 3.1
Chagas 3.1
leeches 3.1
LMS 3.1
Tongue 3.1
Aujeszky's disease 3.0
SCH 3.0
Phenylketonuria 3.0
gastroschisis 3.0
amebiasis 2.9
SMD 2.9
phenylketonuria 2.9
LCP 2.9
GSH 2.9
mitochondrial myopathy 2.9
more...
Symptom
Macula 7.1
Gasping 7.1
Deafferentation 6.6
dyschezia 5.2
ACHE 5.1
Decreased activity 4.9
Neuropathic pain 4.1
eds 3.9
ketonuria 3.9
clonus 3.5
incoordination 3.2
orofacial pain 3.1
twitching 3.0
urinary frequency 2.9
abnormal gait 2.9
nasal congestion 2.8
pallor 2.7
chronic constipation 2.7
tonic-clonic seizure 2.6
anosmia 2.4
sciatica 2.4
myalgia 2.3
functional recovery 2.3
neuralgia 2.2
tachypnea 1.7
constipation 1.7
polyuria 1.4
seizures 1.3
spasticity 1.3
ophthalmoplegia 1.3
arthralgia 1.2
cerebellar ataxia 1.2
memory loss 1.2
cyanosis 1.1
acute pain 1.0
analgesia 1.0
dystonia 1.0
hypothermia 0.9
anesthesia 0.8
acute stress 0.8
paresthesia 0.7
thinning 0.5
lethargy 0.5
fatigue 0.5
hepatomegaly 0.5
hypotonia 0.5
hemoptysis 0.4
tremor 0.4
starvation 0.4
sleepiness 0.4
respiratory distress 0.3
pain 0.3
anorexia 0.2
spasm 0.1
hypercapnia 0.0
ataxia 0.0
syncope -0.2
distraction -0.2
weakness -0.2
splenomegaly -0.3
insomnia -0.4
agitation -0.6
back pain -0.6
stigma -0.7
exhaustion -0.7
acidity -0.9
vomiting -1.0
headache -1.2
nausea -1.5
overweight -1.7
dyspnea -1.8
collapse -1.8
diarrhea -2.8
Drug
Cocarboxylase 10.2
Pentaerythritol tetranitrate 10.1
Duroquinone 9.4
Coix seed 8.9
NADH 7.6
Atabrine 7.1
FAD 6.8
Kainic acid 6.8
Triptorelin 6.8
CET 6.7
7-Nitroindazole 6.5
NBT 6.3
Sodium nitroprusside 6.2
Idebenone 6.1
Nitric Oxide 6.0
Fenbendazole 5.7
EPL 5.6
Vardenafil 5.6
Ethylenediamine 5.2
Trifluoperazine 5.2
Cibacron Blue 5.1
Primaquine 5.1
Methylene blue 5.0
Photofrin II 5.0
Pyridoxal 5.0
Guanethidine 4.9
Vitamin K 4.9
Orlistat 4.4
Riboflavin 4.4
Aminoguanidine 4.3
DFP 4.1
OMP 4.1
GHRP 3.9
Captopril 3.8
Apomorphine 3.7
Heme 3.7
Glutathione 3.4
L-tyrosine 3.4
Clonidine 3.3
Gastro 3.2
Reserpine 3.0
PFA 3.0
Atropine 2.9
G418 2.9
HCH 2.8
Glycerol 2.8
PCP 2.7
Vitamin B 2.7
Ouabain 2.7
pyridoxal phosphate 2.7
nitroglycerin 2.7
ascorbate 2.6
Ethanol 2.5
ALA 2.5
Amiloride 2.4
BH4 2.4
balanced salt solution 2.4
Ginseng 2.3
Simvastatin 2.3
Retinoic acid 2.3
PTC 2.2
Amiloride 2.2
niacin 2.1
Frontal 2.0
Paraffin 1.9
Gel 1.7
EE2 1.6
Forskolin 1.6
HCG 1.6
AZT 1.6
Bifidobacterium 1.5
Growth hormone 1.5
AZT 1.4
Growth hormone 1.4
Indomethacin 1.4
Taxol 1.4
Vitamin E 1.3
ROS 1.1
p75 1.1
Portal 1.0
caffeine 0.9
vitamin E 0.9
ABC 0.9
Nephron 0.9
Adriamycin 0.8
citric acid 0.7
CTX 0.7
MAP 0.6
ICI 0.6
Histamine 0.6
lysine 0.3
IFN-gamma -0.2
Asn -0.5
Nephron -0.6
CSF -0.9
lactose -1.0
Leaf -1.4
IL-2 -1.8
Dial -1.9
Cardiovasc -2.0
Dermatol -3.4
Enzyme
4NQO reductase 13.0
NADPH-diaphorase 13.0
malate-lactate transhydrogenase 13.0
diaphorase 12.5
asparagusate dehydrogenase 12.0
diaphorase 11.4
NQO1 11.3
EC 1.1.1.108 11.0
12alpha-hydroxysteroid dehydrogenase 10.7
melilotate hydroxylase 10.4
2-aminobenzoyl-CoA monooxygenase/reductase 10.2
D-sorbitol dehydrogenase 10.1
aquacobalamin reductase 9.8
aquacobalamin reductase 9.8
bidirectional hydrogenase 9.7
ferric leghemoglobin reductase 9.7
2-aminobenzoate-CoA ligase 9.7
NO synthase 9.7
NAD+ synthetase 9.5
4-hydroxyproline 2-epimerase 9.4
adrenodoxin reductase 9.1
4-hydroxybutyrate dehydrogenase 9.0
enoate reductase 8.9
nicotinic acid hydroxylase 8.7
glutathione oxidase 8.7
acylcarnitine hydrolase 8.6
D-galactose dehydrogenase 8.6
KGOR 8.5
allantoate amidohydrolase 8.4
protochlorophyllide oxidoreductase 8.3
beta-hydroxybutyrate dehydrogenase 8.2
chorismate synthase 8.2
3beta-HSDH 8.2
EC 1.1.1.47 8.0
hydroxylamine reductase 8.0
hydroxylamine reductase 8.0
hydroxyprostaglandin dehydrogenase 8.0
NADH-cytochrome b5 reductase 7.9
NOS 7.9
putrescine oxidase 7.8
threonine aldolase 7.8
LDT 7.7
nicotinamide adenine dinucleotide glycohydrolase 7.7
transhydrogenase 7.6
NAD+ kinase 7.6
DHOdehase 7.6
dihydrodipicolinate reductase 7.4
EC 1.7.7.1 7.4
glycine reductase 7.4
argininosuccinate lyase 7.3
glycerol-3-phosphate oxidase 7.3
choline acetyltransferase 7.1
fructose-6-phosphate phosphoketolase 7.1
succinic dehydrogenase 7.1
benzoate dioxygenase 7.1
lactic acid dehydrogenase 7.1
flavin reductase 7.1
D-dopachrome tautomerase 7.0
lactic acid dehydrogenase 7.0
NADPH oxidase 6.8
cytochrome b6/f complex 6.8
glycerol dehydrogenase 6.8
argininosuccinate synthetase 6.7
pyruvate:ferredoxin oxidoreductase 6.7
glycerol dehydrogenase 6.7
glyoxylate reductase 6.7
glucose dehydrogenase 6.7
glyoxylate reductase 6.7
glycerol-3-phosphate dehydrogenase 6.7
glycerol-3-phosphate dehydrogenase 6.6
NADH dehydrogenase 6.6
bilirubin oxidase 6.6
gluconate dehydrogenase 6.5
succinate dehydrogenase 6.5
phosphoglycolate phosphatase 6.4
kynurenine 3-monooxygenase 6.4
CPR 6.4
leucine dehydrogenase 6.4
glucose-6-phosphate dehydrogenase 6.4
NAD glycohydrolase 6.3
ferredoxin reductase 6.3
azoreductase 6.1
allantoinase 6.1
esterase D 6.0
tyrosine hydroxylase 6.0
hydrogenase 6.0
lactate oxidase 6.0
hydrogenase 6.0
nicotinamide mononucleotide adenylyltransferase 6.0
guanylate cyclase 6.0
nitrate reductase 5.9
formate dehydrogenase 5.9
alanine dehydrogenase 5.9
cytochrome oxidase 5.9
formate dehydrogenase 5.9
formate dehydrogenase 5.9
nitrite reductase 5.8
6-phosphogluconate dehydrogenase 5.8
6-phosphogluconate dehydrogenase 5.8
nitrite reductase 5.8
nitrite reductase 5.8
UMP kinase 5.8
glucose-6-phosphatase 5.8
malate dehydrogenase 5.8
shikimate dehydrogenase 5.8
nitrate reductase 5.7
nitrate reductase 5.7
nitrate reductase 5.7
nitrate reductase 5.7
p-hydroxybenzoate hydroxylase 5.7
nitrate reductase 5.7
MDH 5.7
sulfite reductase 5.6
sulfite reductase 5.6
oxaloacetate decarboxylase 5.6
p-hydroxybenzoate hydroxylase 5.6
phosphoglucomutase 5.6
sulfite reductase 5.6
MDH 5.6
17beta-HSD 5.6
trypanothione reductase 5.5
3alpha-hydroxysteroid dehydrogenase 5.5
leucine aminopeptidase 5.5
isocitrate dehydrogenase 5.4
NQO2 5.4
salicylate hydroxylase 5.4
acetylcholinesterase 5.3
17beta-HSD 5.3
aspartase 5.3
PHD 5.2
NAD+ oxidoreductase 5.2
glutamate dehydrogenase 5.2
acid phosphatase 5.2
glutamate dehydrogenase 5.2
glutamate dehydrogenase 5.1
dopamine beta-hydroxylase 5.1
acetate kinase 5.1
complex I 5.1
PPH 5.1
phosphoglucose isomerase 5.1
glycerol kinase 5.1
glutamate synthase 5.0
lactic acid dehydrogenase 5.0
glutamate synthase 5.0
carbonyl reductase 5.0
isocitrate dehydrogenase 4.9
condensing enzyme 4.9
xylitol dehydrogenase 4.9
glutamate decarboxylase 4.9
thioredoxin reductase 4.9
biliverdin reductase 4.9
fumarase 4.9
xylitol dehydrogenase 4.8
glutathione reductase 4.8
serine racemase 4.8
serine hydroxymethyltransferase 4.8
dimethylarginine dimethylaminohydrolase 4.7
phenylethanolamine N-methyltransferase 4.7
xanthine dehydrogenase 4.7
phosphoglycerate dehydrogenase 4.7
more...
Compound
Optochin hydrochloride 13.0
S-Methylisothiourea sulfate 13.0
Asparagusate 12.0
1-bromoheptane 11.6
Festuclavine 11.0
Aquacobalamin 11.0
CB 1954 10.9
TNBT 10.7
spirost-5-en-3-ol 10.7
Trichloropropene oxide 10.4
Wuweizisu C 10.4
C10H16O 10.0
2,2,6-trimethylcyclohexanone 9.8
2,2,6-trimethylcyclohexanone 9.8
Ferredoxin 8.9
dihydrolipoamide 8.9
Duroquinone 8.9
p-Nitrobenzoic acid 8.7
L-Homocysteic acid 8.7
nicotinamide 8.7
NMOR 8.6
Avertin 8.6
C14H12N2 8.5
L-dopachrome 8.5
Chlorophyllide 8.4
Fe(CN)3 8.4
Nitrofuran 8.4
L-Kynurenine 8.4
2-cyclohexen-1-one 8.3
NADPH 8.3
NADPH 8.3
1,3-Dinitrobenzene 8.2
2,6-dichlorophenol 8.0
Argininosuccinate 7.9
Chorismate 7.9
Ferricyanide 7.7
7-Ethoxyresorufin 7.7
Chicago Sky Blue 6B 7.7
3-O-methyldopamine 7.6
Methylazoxymethanol 7.6
3-Hydroxykynurenine 7.6
NADH 7.6
Protochlorophyllide 7.5
Pyrithiamine 7.5
NADP 7.4
BHC 7.4
Ethylparaben 7.3
Ferrocyanide 7.3
CIT 7.3
DPN 7.2
Phenanthrenequinone 7.2
Lipozyme 7.2
3-buten-2-one 7.1
Quinolinic acid 7.1
CYN 7.1
FMN 7.1
8-Br-cGMP 7.1
OPDA 7.1
3-buten-2-one 7.0
FMNH 7.0
DCIP 7.0
Pterin 7.0
Sepiapterin 7.0
6R-BH4 7.0
Cinnamyl alcohol 6.9
D-Arginine 6.9
FAD 6.8
Kainic acid 6.8
Kainic acid 6.8
Levcromakalim 6.8
nitric oxide 6.8
Biocytin 6.8
3-Nitrotyrosine 6.8
Relaxant 6.8
Malonate 6.7
C3H7NO 6.7
3-Hydroxykynurenine 6.7
Nitro-L-arginine 6.6
Molybdenum cofactor 6.6
allantoate 6.6
NAD 6.5
C3H7NO 6.5
N'-methylnicotinamide 6.5
NBT 6.5
NAD 6.5
FCB 6.5
Diethyl pyrocarbonate 6.5
1,2,4-benzotriazine 6.4
Trp-P-2 6.4
Phenylarsine oxide 6.3
Tanakan 6.3
hydroxytyramine 6.3
Copper sulfate 6.3
Resazurin 6.1
Zinc protoporphyrin 6.1
docosanoic acid 6.1
3,4-dihydroxybenzaldehyde 6.1
1,4-butanediamine 6.0
Ergot 6.0
22R-hydroxycholesterol 6.0
Cyanine 5.9
N-methylnicotinamide 5.9
DLA 5.9
naphthoquinone 5.9
naphthoquinone 5.9
naphthoquinone 5.9
naphthoquinone 5.9
naphthoquinone 5.9
naphthoquinone 5.9
Polydatin 5.9
4-chloro-1-naphthol 5.9
INT 5.9
Quinacrine 5.8
2-Oxoglutarate 5.8
naphthoquinone 5.8
2-furoic acid 5.8
Ibogaine 5.8
2-aminobenzoic acid 5.8
2-aminobenzoic acid 5.7
pentaerythritol 5.7
BayK8644 5.7
DBB 5.7
Cyclic ADP-ribose 5.7
3,4-dihydroxybenzaldehyde 5.7
2-furoic acid 5.7
FANFT 5.7
Paraformaldehyde 5.7
Nifurtimox 5.6
isocitrate 5.6
Equol 5.6
6-phosphogluconate 5.6
cGMP 5.6
Bethanechol 5.6
androst-4-ene-3,17-dione 5.5
Barbiturate 5.4
DTE 5.4
Glycerol-3-phosphate 5.3
Genipin 5.3
Rotenone 5.3
D-gluconate 5.3
Paraformaldehyde 5.3
glucose-6-phosphate 5.3
Diosgenin 5.3
Methylene blue 5.3
Fumarate 5.3
Neuronal 5.3
Substance P 5.2
phosphate 5.2
Trifluoperazine 5.2
BHA 5.2
Plumbagin 5.2
Glycolate 5.1
Hexamethonium 5.1
DBH 5.1
2-oxobutyrate 5.1
Primaquine 5.1
MGBG 5.1
MGBG 5.1
Neutral Red 5.0
arginine 5.0
more...