Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.1 (NADPH-diaphorase)
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Human Gene/Protein
nitric oxide synthase 2055
diaphorase 1890
NADPH 952
NADH 477
neuronal nitric oxide synthase 278
Sep 248
NAD 228
reductase 182
acetylcholinesterase 143
olfactory 129
tyrosine hydroxylase 125
NADP 120
substance P 120
neuropeptide Y 118
Mol 114
choline acetyltransferase 110
somatostatin 104
oxidoreductase 102
inducible nitric oxide synthase 102
calbindin 101
polypeptide 93
calcitonin 84
ferredoxin 81
axonal 80
FAD 77
superoxide dismutase 76
lactate dehydrogenase 76
parvalbumin 75
endoplasmic reticulum 68
cytochrome c 67
glucose-6-phosphate dehydrogenase 66
calretinin 64
flavoprotein 63
GABA 62
CA1 61
peroxidase 60
ATP 60
alkaline phosphatase 59
acid phosphatase 56
vasoactive intestinal peptide 53
gut 52
NAD+ 52
NADP+ 51
FMN 50
glial fibrillary acidic protein 49
guanylate cyclase 46
eNOS 45
catalase 44
calmodulin 42
microsomal 41
cytochrome 40
vasoactive intestinal peptide (VIP) 40
galanin 39
DT-diaphorase 39
soluble guanylyl cyclase 38
ATPase 38
lipoamide dehydrogenase 37
GSH 35
CA3 35
NMDA receptor 34
Diaphorase 34
vasopressin 33
NADH diaphorase 32
vascular endothelium 32
glutathione reductase 32
esterase 32
lipopolysaccharide 31
endothelial nitric oxide synthase 28
constitutive nitric oxide synthase 27
glutathione peroxidase 26
NADH dehydrogenase 25
oxytocin 24
membrane-bound 24
c-fos 23
xanthine oxidase 23
PCC 22
malate dehydrogenase 22
NADH2 22
hemoglobin 21
glutamate dehydrogenase 21
alcohol dehydrogenase 21
PGP 9.5 21
glucose-6-phosphatase 21
VIP 20
insulin 20
heme oxygenase-1 20
thymus 20
Gen 20
guanylyl cyclase 19
SDS 19
cytochrome P450 19
flavin reductase 19
adenosine triphosphatase 18
collagen 18
cytochrome b 18
ADP 18
glutamic acid decarboxylase 17
glutamate receptor 17
phosphodiesterase 16
albumin 16
quinone reductase 16
SOD 16
P21 15
CO2 14
AMP 14
angiotensin II 14
cholecystokinin 14
CPR 14
calcium-binding protein 14
spermatozoa 14
lipoamide 14
VIII 13
LDH 13
SDH 13
dimeric 13
P14 13
Pseudomonas 13
SIN 13
cytokine 13
glucose dehydrogenase 13
isocitrate dehydrogenase 13
phosphatase 13
hexokinase 13
cytochrome P-450 13
cytochrome c oxidase 12
renin 12
AChE 12
muscarinic receptor 12
ChAT 12
myosin 12
A-I 11
inducible form 11
bradykinin 11
erythroid 11
CA2 11
P10 11
P450 11
cytochrome b5 11
olfactory receptor 11
dynorphin 10
xenobiotic 10
asymmetrical 10
SON 10
ANOVA 10
neurofilament protein 10
kit 10
Rec 10
serum albumin 10
apoE 10
interferon-gamma 10
dopamine beta-hydroxylase 9
leucine aminopeptidase 9
neuron-specific enolase 9
nerve growth factor 9
E14 9
Walker 9
DAF 9
Catalase 9
Neuropeptide Y 9
SNAP 9
more...
Disease
NAME 121
Huntington's disease 63
ischemia 52
cancer 48
diabetes 46
varices 39
Alzheimer's disease 37
GSH 35
tumor 33
hypertension 31
pheochromocytoma 22
PCC 22
Parkinson's disease 20
SDS 19
uterus 18
depression 18
heart failure 15
urethra 14
carcinogenesis 14
cholera 13
schizophrenia 13
epilepsy 12
cold 12
hepatocellular carcinoma 12
cerebral ischemia 11
neuroblastoma 10
erectile dysfunction 10
dehydration 10
amyotrophic lateral sclerosis 10
melanoma 9
atherosclerosis 9
stroke 9
Chagas 9
breast cancer 8
carcinoma 8
dysplasia 8
Lissauer 8
mole 8
mole 8
DIA 7
ureter 7
celiac disease 7
vagina 7
epididymis 7
methemoglobinemia 7
Choroid 6
Mycobacterium 6
hyperglycemia 6
asthma 6
obesity 6
Choroid 6
malnutrition 6
SEM 6
pulmonary hypertension 6
encephalopathy 6
chronic granulomatous disease 6
fits 5
Evans 5
herpes simplex 5
status epilepticus 5
cholestasis 5
impotence 5
achalasia 5
SCH 5
paraplegia 5
tuberculosis 5
cirrhosis 5
ulcerative colitis 5
DBA 5
dyskinesia 4
cardiosclerosis 4
dementia 4
neuropathy 4
hepatitis 4
enzyme deficiency 4
Pancreas 4
NCR 4
worms 4
diabetic neuropathy 4
nerve lesion 4
sepsis 4
movement disorder 4
pertussis 4
uterine cervix 4
MCF 4
multiple sclerosis 4
chronic renal failure 4
PNS 4
EDA 4
AIDS 4
glioma 4
cytomegalovirus 4
plaque 4
hemolytic anemia 4
sepsis 4
intraocular pressure 4
Crohn's disease 4
cognitive impairment 4
Pancreas 4
sleep disorders 4
disinhibition 4
cornea 3
keratocyst 3
NBS 3
parkinsonism 3
addiction 3
colitis 3
pulmonary tuberculosis 3
Duchenne muscular dystrophy 3
psychological stress 3
inflammatory bowel disease 3
coronary heart disease 3
pulpitis 3
encephalomyelitis 3
Fox 3
immunodeficiency 3
Fallopian tube 3
myopathy 3
CGD 3
adenocarcinoma 3
brain dysfunction 3
immaturity 3
virus infection 3
portal hypertension 3
viral hepatitis 3
GAD 3
Krabbe disease 3
cardiovascular disease 3
alcohol abuse 3
Steroids 3
PCP 3
Bardet-Biedl syndrome 3
DTD 3
gastroesophageal reflux disease 3
bladder cancer 3
hyperosmolality 3
Melanoma 3
myeloblastosis 3
megacolon 3
phenylketonuria 3
tetanus 2
neurological disease 2
trypanosomiasis 2
polyneuropathy 2
sensory neuropathy 2
African trypanosomiasis 2
mental retardation 2
retinitis pigmentosa 2
leptospirosis 2
PSA 2
retinopathy 2
thiamine deficiency 2
Schistosoma mansoni 2
seminal vesicles 2
infectious diseases 2
leukemia 2
hernia 2
liver metastases 2
Pineal 2
rabies 2
more...
Symptom
pain 39
seizures 25
anesthesia 24
fatigue 9
functional recovery 8
analgesia 7
weakness 4
myalgia 4
hypothermia 4
starvation 4
constipation 4
tremor 3
respiratory distress 3
headache 3
Neuropathic pain 3
Deafferentation 2
twitching 2
spasticity 2
ataxia 2
pallor 2
anorexia 2
Decreased activity 2
eds 2
dystonia 2
incoordination 2
vomiting 2
Macula 2
arthralgia 2
thinning 2
sleepiness 2
memory loss 1
collapse 1
overweight 1
polyuria 1
syncope 1
stigma 1
sciatica 1
tonic-clonic seizure 1
hemoptysis 1
splenomegaly 1
acute pain 1
hypotonia 1
insomnia 1
acidity 1
nasal congestion 1
nausea 1
ACHE 1
urinary frequency 1
hepatomegaly 1
agitation 1
distraction 1
neuralgia 1
clonus 1
chronic constipation 1
back pain 1
ophthalmoplegia 1
cyanosis 1
abnormal gait 1
cerebellar ataxia 1
spasm 1
hypercapnia 1
lethargy 1
diarrhea 1
paresthesia 1
orofacial pain 1
exhaustion 1
ketonuria 1
Gasping 1
anosmia 1
acute stress 1
tachypnea 1
dyspnea 1
dyschezia 1
Drug
NADH 509
FAD 77
Nitric Oxide 21
ascorbate 17
NBT 13
lysine 9
Kainic acid 9
Sodium nitroprusside 9
Ethanol 7
nitroglycerin 7
Glutathione 7
Gel 6
Cardiovasc 6
Vitamin K 5
ROS 5
Methylene blue 5
Heme 5
caffeine 5
Captopril 4
Nephron 4
vitamin E 4
Atropine 3
MAP 3
EE2 3
Clonidine 3
IFN-gamma 3
L-tyrosine 3
HCH 3
Pentaerythritol tetranitrate 3
PCP 3
Dermatol 3
DFP 2
Glycerol 2
ABC 2
ALA 2
Ouabain 2
G418 2
Riboflavin 2
CET 2
Trifluoperazine 2
niacin 2
CSF 2
Retinoic acid 2
pyridoxal phosphate 2
citric acid 2
Cibacron Blue 2
CTX 2
Indomethacin 2
Bifidobacterium 2
Apomorphine 2
Idebenone 1
AZT 1
Guanethidine 1
Simvastatin 1
Histamine 1
Vardenafil 1
PTC 1
Ethylenediamine 1
Reserpine 1
Asn 1
Vitamin E 1
Atabrine 1
ICI 1
p75 1
Fenbendazole 1
Adriamycin 1
7-Nitroindazole 1
Cocarboxylase 1
Amiloride 1
Amiloride 1
Growth hormone 1
Pyridoxal 1
Primaquine 1
AZT 1
Growth hormone 1
Orlistat 1
Aminoguanidine 1
Ginseng 1
Photofrin II 1
PFA 1
Triptorelin 1
Paraffin 1
Taxol 1
BH4 1
HCG 1
OMP 1
GHRP 1
Nephron 1
Dial 1
Duroquinone 1
Frontal 1
balanced salt solution 1
Forskolin 1
lactose 1
Coix seed 1
Leaf 1
EPL 1
IL-2 1
Gastro 1
Vitamin B 1
Portal 1
Enzyme
NADPH-diaphorase 3903
diaphorase 1920
NQO1 1903
diaphorase 1893
NO synthase 1564
NOS 211
NADPH oxidase 144
acetylcholinesterase 141
tyrosine hydroxylase 119
choline acetyltransferase 110
succinate dehydrogenase 92
lactate dehydrogenase 91
superoxide dismutase 82
glucose-6-phosphate dehydrogenase 78
peroxidase 74
guanylate cyclase 65
cytochrome oxidase 63
alkaline phosphatase 60
ATPase 59
acid phosphatase 57
CPR 55
catalase 46
adrenodoxin reductase 39
complex I 37
glutathione reductase 33
malate dehydrogenase 31
succinic dehydrogenase 30
nitrate reductase 29
hydrogenase 28
NADPH oxidase 28
glutathione peroxidase 28
hydrogenase 28
NADH dehydrogenase 25
nitrate reductase 24
alcohol dehydrogenase 24
nitrate reductase 24
nitrate reductase 24
nitrate reductase 24
nitrate reductase 24
glycerol-3-phosphate dehydrogenase 22
glycerol-3-phosphate dehydrogenase 22
xanthine oxidase 21
glucose-6-phosphatase 21
glutamate dehydrogenase 20
glutamate dehydrogenase 19
glutamate dehydrogenase 19
transhydrogenase 17
isocitrate dehydrogenase 16
NADH-cytochrome b5 reductase 16
phosphodiesterase 16
beta-hydroxybutyrate dehydrogenase 14
heme oxygenase 13
nitrite reductase 13
cholinesterase 13
isocitrate dehydrogenase 13
nitrite reductase 13
nitrite reductase 13
hexokinase 13
phosphorylase 13
monoamine oxidase 13
glucose dehydrogenase 13
renin 12
protochlorophyllide oxidoreductase 12
glutathione S-transferase 12
6-phosphogluconate dehydrogenase 10
protein kinase 10
HSD 10
reverse transcriptase 10
gamma-glutamyl transpeptidase 10
6-phosphogluconate dehydrogenase 10
argininosuccinate synthetase 9
aspartate aminotransferase 9
thioredoxin reductase 9
leucine aminopeptidase 9
pyruvate dehydrogenase 8
lipase 8
lactic acid dehydrogenase 8
formate dehydrogenase 8
luciferase 8
trypsin 8
argininosuccinate lyase 8
glutamate decarboxylase 8
phosphoglucomutase 8
phosphoglucose isomerase 7
carbonic anhydrase 7
lactic acid dehydrogenase 7
ERK 7
formate dehydrogenase 7
formate dehydrogenase 7
glucose oxidase 7
glyceraldehyde-3-phosphate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
adenylate kinase 6
pyruvate kinase 6
enolase 6
glyceraldehyde-3-phosphate dehydrogenase 6
dopamine beta-hydroxylase 6
carboxylesterase 6
glyceraldehyde-3-phosphate dehydrogenase 6
beta-galactosidase 6
pyruvate dehydrogenase 6
pyruvate dehydrogenase 6
protein kinase C 6
tyrosinase 6
mitogen-activated protein kinase 6
arginase 6
ACS 5
alanine aminotransferase 5
MDH 5
aldehyde dehydrogenase 5
beta-glucuronidase 5
aryl hydrocarbon hydroxylase 5
flavin reductase 5
aldolase 5
glyceraldehyde-3-phosphate dehydrogenase 5
5'-nucleotidase 5
bidirectional hydrogenase 5
MDH 5
aldehyde dehydrogenase 5
caspase-3 5
NAD glycohydrolase 4
nitrogenase 4
calcineurin 4
PHD 4
fumarase 4
adenylate cyclase 4
aconitase 4
PKG 4
ceruloplasmin 4
ACE 4
xanthine dehydrogenase 4
aldehyde dehydrogenase 4
gamma-glutamylcysteine synthetase 4
11beta-hydroxysteroid dehydrogenase 4
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
creatine kinase 4
glycerol dehydrogenase 3
chymotrypsin 3
bilirubin oxidase 3
PCP 3
glycerol kinase 3
4NQO reductase 3
proteasome 3
hydroxyprostaglandin dehydrogenase 3
azoreductase 3
lactic acid dehydrogenase 3
myosin ATPase 3
glutamate synthase 3
ferredoxin reductase 3
peroxiredoxin 3
phospholipase A2 3
pyruvate:ferredoxin oxidoreductase 3
dihydrofolate reductase 3
ATP synthase 3
glutamine synthetase 3
thrombin 3
citrate synthase 3
D-sorbitol dehydrogenase 3
lactate oxidase 3
more...
Compound
nitric oxide 1346
NADPH 958
NADPH 957
nicotinamide 814
phosphate 803
NADH 506
arginine 387
Dec 306
NAD 284
NADP 241
NAD 228
oxygen 166
sodium 147
calcium 147
cGMP 123
glutamate 95
water 94
glucose 90
hydrogen 82
FAD 78
DNA 71
salt 67
GABA 63
GABA 62
ATP 60
Clin 54
Neuronal 53
FMN 51
CIT 51
iron 49
nitrate 46
ethanol 42
GSH 39
nitrogen 39
GSH 39
sulfate 38
CO2 35
5-HT 34
NMDA 32
acetate 31
pyridine 31
GMP 27
gamma-aminobutyric acid 27
silver 27
potassium 27
H2O2 27
formaldehyde 26
tyrosine 25
formaldehyde 24
cysteine 23
His 23
cyanide 23
aldehyde 22
fluorine 22
alcohol dehydrogenase 22
Ferredoxin 21
naphthoquinone 20
naphthoquinone 20
naphthoquinone 20
naphthoquinone 20
copper 20
SDS 20
ACh 20
ADP 20
naphthoquinone 20
naphthoquinone 20
ammonium 20
naphthoquinone 20
methionine 19
ADP 18
ADP 18
Triton X-100 18
EDTA 18
noradrenaline 17
glucose-6-phosphate 17
EDTA 17
aldehyde 17
leucine 16
NBT 16
tryptophan 15
urea 15
Glutamate 15
Substance P 15
glycerol 14
tryptophan 14
zinc 14
tryptophan 14
lysine 14
hydroxylamine 14
AMP 14
galactose 14
hydroxylamine 14
tryptophan 14
Nicotine 14
Phe 14
pyrene 13
pentose 13
pentose 13
pentose 13
pentose 13
2-oxoglutarate 13
Cereb 13
Yellow 13
glutamine 12
CB 1954 12
dihydrolipoamide 12
hexose 12
cAMP 12
hexose 11
BHC 11
methanol 11
DEAE 11
hexose 11
8-Br-cGMP 11
hydroquinone 11
hexose 11
ornithine 10
ornithine 10
ammonia 10
bromide 10
phenol 10
alanine 10
molybdenum 10
phenazine 10
isocitrate 10
serine 10
ornithine 10
ornithine 10
2,6-dichlorophenol 10
ornithine 10
GSSG 9
nickel 9
Kainic acid 9
iodine 9
DPN 9
retinoic acid 9
Methylene blue 9
Kainic acid 9
CoA 9
isoxazole 8
dUTP 8
Mg2+ 8
N-acetylcysteine 8
manganese 8
Calcitonin 8
L-DOPA 8
superoxide radical 8
ubiquinone 8
selenium 7
Gly 7
NO3 7
mercury 7
PGE 7
AMPA 7
malic acid 7
DBA 7
HCl 7
PAS 7
Tris 6
INT 6
more...