Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.6.99.1 (NADPH-diaphorase)
 3,903 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

NADPH-diaphorase histochemistry was used to study the distribution and density of labeled neurons in the limbic structures and hypothalamus in intact rat. NADPH-diaphorase positive neurons were registered in the basal forebrain-medial septal nucleus (MS), the nuclei of the diagonal band of Broca (VDB, HDB), substancia innominata (SI) and the nucleus basalis of Meynert (B). These areas largely overlap with the cholinergic CH1-CH4 forebrain system of the rodent brain. The order of density of labeled neurons in different regions of the basal forebrain was as following sequence: HDB > VDB > SI > B. The highest densities of the reactive neurons (> 1000 labeled neurons per section 200x200 microm2) was found in the islands of Calleja (ICjs). In the supraoptic (SO) and paraventricular (Pa) nuclei of hypothalamus were recorded > 130 and > 100 labeled units, respectively. The lowest density of labeled neurons was recorded within the SI-B complex: < 10 reactive units. Reactive neurons, their dendrites and axon-like processes within the ICjs, SO, Pa, the lateral nucleus hypothalamus (LH) often surround arterioles which traverse the structures. We suggest that NADPH-diaphorase-reactive (NO-generating) neurons within the ICjs and hypothalamus are involved in regulation of the regional, blood flow (RBF) that is important to adapt the blood flow to changes in neuronal activity of the basal forebrain structures.
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PMID:[NADPH-diaphorase neurons and their interrelationship with microvascular vessels in the basal forebrain limbic structures and hypothalamus]. 1808 Apr 92