Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.99.1 (NADPH-diaphorase)
 3,903 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Kidneys from 90 individuals who had died from atherosclerosis, hypertensive disease, or chronic glomerulonephritis were examined following early autopsies. The nephron epithelium and the endothelium of peritubular capillaries were studied for activities and distribution patterns of NADPH2 dehydrogenase, lactate dehydrogenase, succinate dehydrogenase, and acid and alkaline phosphatases, for relative capillary and connective tissue volumes, and for lymphocyte, monocyte, and plasma cell numbers. A mathematical analysis of the histochemical and morphometric data provided information on the nature of changes in the renal microcirculatory bed and on the roles of free stromal cells in various forms of nephrosclerosis as well as on the zonal distribution of the parameters studied. Intercellular and vascular-cellular links were found to be weakest in the most advanced stage of chronic glomerulonephritis involving reduction of peritubular capillaries. In cardiovascular disorders, the morphofunctional characteristics of the microcirculatory bed and of its volume showed reciprocal changes, probably of a compensatory character.
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PMID:[Interrelation of changes in the epithelium of kidney tubules and interstitium in nephrosclerosis based on morphometric and histochemical data]. 366 62

The authors have evaluated the effects of Simvastatin on the lipid blood spectrum and nitric oxide in patients with chronic glomerulonephritis (CGN). 100 patients with different types of glomerular disease were divided in two groups depending on the treatment scheme: Group B received the traditional therapy, Group A patients received traditional therapy + 20 mg Simvastatin per day. Nitric oxide radicals, NADPF-diaphorase, nitrate reductase, acetylcholinesterase enzymes, as well as total cholesterol, triglycerides, HD, LD, VLD lipoproteins concentration were assessed initially and after three month treatment. It was revealed that the treatment with statins taking into account types of dislipidemia could have an additional renoprotective effect in the patients with different types of chronic glomerular disease.
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PMID:[Effects of simvastatin therapy on the lipid blood spectrum and nitric oxide in patients with chronic glomerulonephritis]. 1966 18