Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.6.5.4 (SOR)
 720 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transurethral incision of the prostate and bladder neck (TIPBn) was compared with transurethral resection of the prostate (TURP) followed by bladder neck incision in the treatment of 22 patients with outflow obstruction caused by a small prostate adenoma (below 15 gm). Eleven patients underwent TIPBn and another 11 TURP. An evaluation of the urodynamic findings and subjective symptoms was undertaken before the operation and 3 months afterwards. Urodynamic findings were evaluated, based upon uroflowmetry, i.e., in terms of maximum flow rate, average flow rate, voiding time, initiation time and residual rate. All patients in the TIPBn group revealed an improvement in every urodynamic parameter (MFR: from 6.1 to 10.8 ml/sec, AFR: from 3.1 to 5.8 ml/sec, Voiding time: from 95.5 to 24.2 sec/100 ml, Initiation time: 34.3 to 10.2 sec, Residual rate: 31.6 to 17.8%, in mean value). Ten out of the 11 in the TIPBn group subjectively considered the result to be good. The improvements in the urodynamic parameters in the TIPBn group were statistically comparable to those in the TURP. The improvements in voiding time and initiation time, however, tended to be much better in the TIPBn group. We conclude that TIPBn can be the operation of choice in the treatment of outflow obstruction caused by a small prostate.
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PMID:[Transurethral incision of the prostate and bladder neck for the treatment of outflow obstruction caused by a small benign prostate]. 170 Jan 81

Uroflowmetry was examined in 192 patients with obstructive urinary symptoms. They were 173 males with obstructive diseases in lower urinary tract (302 uroflowmetric studies) and 19 males with neurogenic bladder (29 uroflowmetric studies). We classified the patterns of uroflowmetric curve into 6 types: N type (normal), NB type (neurogenic bladder: wave like curve), OB type (obstructive diseases: flat curve), AP type (anterior peak), PP type (posterior peak) and OT type (others). The 331 uroflowmetric curves were classified into the above 6 types, and the relationship between each type of flow curve and other uroflowmetric parameters (voided volume = VV, residual urine volume = RU, maximum flow rate = MFR, average flow rate = AFR) was analyzed. The types of 229 flow studies (140 patients) in benign prostatic hypertrophy were OB (77.7%), AP (16.6%), OT (3.9%), N (0.9%) and PP (0.9%). The types of 39 flow studies (25 patients) in prostatic cancer and 13 studies (8 patients) in urethral stricture were similar; 92.3% of the flow studies being classified into OB type. The types of 21 flow studies (10 patients) in so-called bladder neck contraction were OB (42.9%), AP (33.3%), OT (14.3%) and NB (9.5%). AP type flow curves were more frequent than other in obstructive diseases.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Study on voiding disturbance in elderly males. II. Analysis of the patterns in uroflowmetric studies in patients with obstructive diseases in lower urinary tract and neurogenic bladder]. 241 65

We performed uroflowmetric study in 8 boys (7 approximately 14 years old), 20 young adults (19 approximately 39 years old) and 552 elderly men (40 approximately 93 years old) with a DISA 21C10 mictiometer, and obtained 753 studies. Uroflowmetric studies were classified into 6 patterns: N type (normal), NB type (neurogenic bladder: wave-like curve), OB type (obstructive diseases: flat curve), AP type (anterior peak), PP type (posterior peak) and OT type (others). We studied the relationship between age and uroflowmetry with patterns and flow rates (maximum flow rate = MFR, average flow rate = AFR). In men over 19 years old, flow rates (MFR, AFR) decreased proportionally with age (MFR: 2.9 ml/s/10 years old, AFR: 1.6 ml/s/10 years old). In elderly men (over 40 years old), the N type flow curve decreased and OB type flow curves increased gradually with age.
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PMID:[Study of voiding disturbances in elderly males. III. Analysis of flow rates and patterns in uroflowmetric studies: comparison between children, young adults and elderly men]. 361 23

The aim of the study was the estimation of the right ventricular function in patients with hypertrophic cardiomyopathy (HC). 20 patients, 14 men and 6 women of age 23-50 with echocardiography diagnosed hypertrophic cardiomyopathy were examined. Equilibrium gated radionuclide angiography was performed in all patients. Right and left ventricle ejection fraction (EF), 1/3 first ejection fraction (1/3EF), maximal and average rate of emptying (MER, AER), time to peak emptying (TTPE), 1/3 first filling fraction (1/3FF), maximal and average rate of filling (MFR, AFR), time to peak filling (TTPF) and MFR/MER ratio were calculated. Analysing function of right ventricle in patients with HC impaired diastolic function was observed. MFR was 1.44 +/- 0.54EDV/s,AFR-0.95 +/- 0.24EDV/s, 1/3 FF-0.49 +/- 0.09. Positive correlation between right and left ventricle MFR was found (r = 0.62; p < 0.01). Mean value of RVEF was 40.8 +/- 7%, 1/3EF-17.5 +/- 5%, MER-1.88 +/- 0.4EDV/s, AER-1.59 +/- 0.4EDV/s. Decreased ejection fractions of the right ventricle in patients with the thickest interventricular septum were observed. Mean value of the time to peak emptying was short (x = 68.6 ms). Regional ejection fractions from septum region of RV were decreased. It was the result of the abnormal function of the interventricular septum in patients with hypertrophic cardiomyopathy. Indexes of RV function in the two groups of patients were also analysed: with and without left ventricular outflow tract obstruction. Mean value of RV systolic and diastolic function indexes were similar in two groups of patients. In conclusion, impairment of the right ventricle diastolic function in patients with hypertrophic cardiomyopathy is predominated. The more diastolic function of the RV deteriorates the worse diastolic function of the left ventricle remains in patients with HC.
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PMID:[Evaluation of right ventricular function in patients with hypertrophic cardiomyopathy]. 875 24

Bladder function changes significantly in pregnancy. This study prospectively examined voiding function in a nulliparous cohort. A total of 200 nulliparous women were seen twice during pregnancy and 2-5 months postpartum. Flowmetry, ultrasound estimation of residual urine and translabial ultrasound of bladder neck mobility were evaluated. The Liverpool nomograms were used to calculate maximum and average flow rate (MFR and AFR) centiles. Flowmetry was available on 186 women at 6-18 weeks, 165 women at 32-39 weeks and 162 women 2-5 months postpartum. Voided volumes decreased from 253 to 180 ml during pregnancy (p<0.001), increasing again to 198 ml postpartum. MFR centiles increased during pregnancy [from 49 (SD 28) to 58 (SD 29), p=0.003], and this trend continued postpartum [to 61.8 (SD 26.8), p<0.001]. Changes correlated weakly but significantly with changes in several parameters of bladder neck mobility (e.g. urethral rotation and MFR centiles, r=0.182, p=0.027). MFR and AFR centiles increase in pregnancy and with childbirth, and increases correlate weakly with changes in bladder neck mobility.
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PMID:Voiding function in pregnancy and puerperium. 1545 91