Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.4 (SOR)
 720 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The convergence zone method is currently used routinely to quantify valvular regurgitation, particularly mitral insufficiency, but also aortic and tricuspid regurgitation. It is quick to perform, requires relatively little training and remains valid in the presence of atrial fibrillation and in the association of regurgitation-stenosis. It relies on the measurement of output at the level of an isovelocity hemisphere and allows calculation of the regurgitant orifice surface (SOR) and the regurgitant volume per beat (VR). It is reserved for severe regurgitation corresponding to angiographic grade 4: SOR > 40 mm2 and VR > 60 ml for mitral insufficiency, SOR > 30 mm2 and VR > 60 ml for aortic insufficiency, and SOR > 40 mm2 and VR > 40 ml for tricuspid insufficiency.
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PMID:[Quantification of valvular regurgitation by the convergence zone method]. 1287 Jan 90

The literature on pediatric reflux can be divided into studies addressing clinically apparent reflux (vomiting or regurgitation) and reflux as measured by pH probe or other methods. Sodium alginate reduces vomiting and improves parents' assessment of symptoms (strength of recommendation [SOR]: B, small randomized controlled trial [RCT]). Formula thickened with rice cereal decreases the number of postprandial emesis episodes in infants with gastroesophageal reflux disease (GERD) (SOR: B, small RCT). There are conflicting data on the effect of carob bean gum as a formula thickener and its effect on regurgitation frequency (SOR: B, small RCTs). Metoclopramide does not affect vomiting or regurgitation, but is associated with greater weight gain in infants over 3 months with reflux (SOR: B, low-quality RCTs). Carob bean gum used as a formula thickener decreases reflux as measured by intraluminal impedance but not as measured by pH probe (SOR: B, RCT). Omeprazole and metoclopramide each improve the reflux index as measured by esophageal pH probe (SOR: B, RCT). Evidence is conflicting for other commonly used conservative measures (such as positional changes) or other medications for symptomatic relief of infant GERD. There is very limited evidence or expert opinion regarding breastfed infants, particularly with regard to preservation of breastfeeding during therapy.
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PMID:Clinical inquiries. What is the best treatment for gastroesophageal reflux and vomiting in infants? 1583 33