Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.4 (
SOR
)
720
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We describe the identification and characterization of a novel PcG gene in C. elegans, sor-1, which is involved in global repression of Hox genes. sor-1 encodes a novel protein with an RNA-binding activity. We provide evidence that
SOR
-1 and the previously identified
RNA-binding protein
SOP-2 may constitute an RNA-binding complex in Hox gene repression.
SOR
-1 and SOP-2 directly interact with each other and are colocalized in nuclear bodies. The localization of
SOR
-1 depends on SOP-2. Surprisingly, homologs of
SOR
-1 and SOP-2 are not found in other organisms, including the congeneric species C. briggsae, suggesting an unexpected lack of evolutionary constraint on an essential global gene regulatory system.
...
PMID:RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans. 1650 Nov 68
