Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.4 (
SOR
)
720
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The immediate product of ascorbate oxidation coupled to dopamine-beta-hydroxylation is not dehydroascorbate, as previously thought, but rather semidehydroascorbate. For this reason, the possible participation of the enzyme
semidehydroascorbate reductase
(
SDR
) in cofactor regeneration was investigated. In the adrenal medulla, the primary subcellular localization of this reductase was shown to be in the mitochondria. Submitochondrial fractionation studies indicated that
SDR
is an outer
membrane protein
. Thus, although dopamine-beta-hydroxylase and
SDR
have different subcellular localizations, a physiological role for
SDR
in beta-hydroxylation still appears plausible through reduction of cytosolic semidehydroascorbate. The specific activities of
SDR
in various rat and guinea pig tissues appear to parallel their ascorbate contents, suggesting a similar participation of
SDR
in ascorbate metabolism in other tissues.
...
PMID:Tissue, subcellular, and submitochondrial distributions of semidehydroascorbate reductase: possible role of semidehydroascorbate reductase in cofactor regeneration. 621 23
