Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.3 (complex I)
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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
NADH dehydrogenase 0.227
complex I) 0.043
NADH-ubiquinone oxidoreductase 0.033
NADH-ubiquinone reductase 0.015
NADH 0.013
ubiquinone 0.010
NDUFS4 0.007
B13 0.005
ND1 0.004
NADH: ubiquinone oxidoreductase 0.003
PSST 0.003
NDUFS3 0.003
NDUFS2 0.003
ND5 0.003
NADH-coenzyme Q reductase 0.003
NDUFV1 0.003
ND4 0.002
NDUFS1 0.002
cytochrome c oxidase 0.002
NDUFS7 0.002
PSST subunit 0.002
NDUFV2 0.002
NDUFS8 0.002
NDUFA1 0.002
ND6 0.002
NDUFB11 0.002
complex I assembly factor 0.002
NDUFAF1 0.002
ND3 0.001
oxidoreductase 0.001
MELAS 0.001
TYKY 0.001
GRIM-19 0.001
ACAD9 0.001
ATP synthase 0.001
NAD 0.001
ATP 0.001
NDUFA4 0.001
OXPHOS 0.001
NDUFS6 0.001
NDUFAF2 0.001
FMN 0.001
MPP 0.001
NDUFA7 0.001
NDUFB8 0.001
FOXRED1 0.001
TMEM126B 0.001
ND2 0.001
NDUFA10 0.001
ND4L 0.001
NDUFC2 0.001
citrate synthase 0.001
iron-sulfur protein 3 0.001
flavoprotein 0.001
cytochrome c 0.001
mitochondrial acyl carrier protein 0.001
alpha-ketoglutarate dehydrogenase 0.001
TYKY subunit 0.001
NDUFAB1 0.001
NDUFA12 0.001
MTND1 0.001
GRIM19 0.001
NUBPL 0.001
cytochrome b 0.001
aconitase 0.000
NDUFA11 0.000
NDUFA2 0.000
NDUFB10 0.000
cytochrome 0.000
NDUFV3 0.000
MT-ND2 0.000
quinone oxidoreductase 0.000
ROS 0.000
MT-ND4 0.000
NAD+ 0.000
reductase 0.000
LHON 0.000
NDUFA8 0.000
MTND4 0.000
NDUFS5 0.000
more...
Disease
Leigh syndrome 0.003
Leber's hereditary optic neuropathy 0.003
Complex I deficiency 0.002
mitochondrial disease 0.002
Parkinson's disease 0.001
lactic acidosis 0.001
mitochondrial myopathy 0.001
MELAS 0.001
MELAS 0.001
mitochondrial encephalomyopathy 0.001
GOA1 0.000
optic atrophy 0.000
early parkinson's 0.000
Hereditary optic atrophy 0.000
MTND6*LDYT14459A 0.000
Infantile cardiomyopathy 0.000
Kearns-Sayre syndrome 0.000
OPA1 0.000
parkinsonism 0.000
GSH 0.000
Hyper-beta-alaninemia 0.000
Brisket disease 0.000
Metabolic myopathy 0.000
Disorders of mitochondrial metabolism 0.000
SCAE 0.000
3-Hydroxyisobutyric aciduria 0.000
ischemia 0.000
SPG7 0.000
myopathy 0.000
MERRF 0.000
neuroblastoma 0.000
CMT2K 0.000
encephalopathy 0.000
LSFC 0.000
nanophyetiasis 0.000
Distal Myopathy 0.000
cardiomyopathy 0.000
PDH deficiency 0.000
PARK7 0.000
Chromophobe cell renal carcinoma 0.000
enzyme deficiency 0.000
Fecal peritonitis 0.000
Chronic progressive external ophthalmoplegia 0.000
DEFECT 0.000
sideroblastic anemia 0.000
Neonatal anoxia 0.000
encephalomyelopathy 0.000
leukoencephalopathy 0.000
hypertrophic cardiomyopathy 0.000
MILS 0.000
Alpers 0.000
Barth syndrome 0.000
Friedreich's ataxia 0.000
SCA28 0.000
Alzheimer's disease 0.000
EBSS 0.000
HPA1 0.000
Pearson's syndrome 0.000
Diabetic encephalopathy 0.000
Carotid body 0.000
Carotid body 0.000
Carotid body 0.000
Fazio-Londe 0.000
PARK6 0.000
MNGIE 0.000
CMT4A 0.000
cancer 0.000
NDI 0.000
Huntington's disease 0.000
SDS 0.000
type 2 diabetes 0.000
early onset schizophrenia 0.000
Richner-Hanhart syndrome 0.000
pediatric disorder 0.000
developmental delay 0.000
neuropathy 0.000
PPR 0.000
PCC 0.000
Brown-Vialetto-Van Laere syndrome 0.000
OPA3 0.000
more...
Symptom
Respiration stimulated 0.000
hypotonia 0.000
External ophthalmoplegia 0.000
Exercise intolerance 0.000
ophthalmoplegia 0.000
dystonia 0.000
ataxia 0.000
weakness 0.000
hyperoxia 0.000
collapse 0.000
Cold intolerance 0.000
starvation 0.000
seizures 0.000
cerebellar ataxia 0.000
myoclonus 0.000
spasticity 0.000
dysarthria 0.000
adipsia 0.000
bradykinesia 0.000
impaired motor coordination 0.000
aphagia 0.000
Extrapyramidal symptoms 0.000
paraparesis 0.000
Decreased activity 0.000
athetosis 0.000
male subfertility 0.000
tremor 0.000
visual hallucination 0.000
fatigue 0.000
hangover 0.000
hypothermia 0.000
neurological disability 0.000
functional recovery 0.000
motor symptom 0.000
clumsiness 0.000
Anoxia 0.000
ketonuria 0.000
cachexia 0.000
hepatomegaly 0.000
hypercapnia 0.000
vomiting 0.000
drooling 0.000
consciousness disturbance 0.000
exhaustion 0.000
muscle cramps 0.000
lethargy 0.000
chorea 0.000
hemiplegia 0.000
myalgia 0.000
emaciation 0.000
eds 0.000
anorexia 0.000
anesthesia 0.000
bitter taste 0.000
respiratory distress 0.000
despair 0.000
enuresis 0.000
acidity 0.000
incoordination 0.000
thinning 0.000
polydipsia 0.000
pallor 0.000
constipation 0.000
paresis 0.000
nausea 0.000
diarrhea 0.000
polyuria 0.000
bone pain 0.000
exertional dyspnea 0.000
chills 0.000
hepatosplenomegaly 0.000
headache 0.000
analgesia 0.000
arthralgia 0.000
spasm 0.000
nausea and vomiting 0.000
splenomegaly 0.000
insomnia 0.000
Ill 0.000
overweight 0.000
more...
Drug
NADH 0.013
ROS 0.000
FAD 0.000
Parkin 0.000
Parkin 0.000
Nanaomycin D 0.000
Idebenone 0.000
Duroquinone 0.000
Mubritinib 0.000
Haloperidol Decanoate 0.000
Bupleurum root 0.000
ascorbate 0.000
7-Nitroindazole 0.000
URF 0.000
SMP 0.000
Tuareg 0.000
Atabrine 0.000
citric acid 0.000
vitamin E 0.000
Secobarbital 0.000
Demerol 0.000
Riboflavin 0.000
Flavin 0.000
THF 0.000
Epidoxorubicin 0.000
Glutathione 0.000
Vinpocetine 0.000
Abamectin 0.000
ROX 0.000
Demerol 0.000
Adenosine triphosphate 0.000
2-Methoxyestradiol 0.000
Dronedarone 0.000
Fipronil 0.000
Isoniazid 0.000
Ciprofibrate 0.000
3,4-Dihydroxyphenylalanine 0.000
Adriamycin 0.000
Sodium thiosulfate 0.000
Simvastatin 0.000
Methylene blue 0.000
Aricept 0.000
Paliperidone 0.000
Ranolazine 0.000
Ranolazine 0.000
Sesamol 0.000
Flupenthixol 0.000
Fructose 0.000
AGG 0.000
lysine 0.000
Gel 0.000
Vanilla 0.000
Arsenic trioxide 0.000
Florfenicol 0.000
Guanidine 0.000
Guanidine 0.000
Rebamipide 0.000
Caspofungin 0.000
Rasagiline 0.000
Podophyllum 0.000
SPP 0.000
Atovaquone 0.000
Indomethacin 0.000
Tibolone 0.000
Agomelatine 0.000
Carbenoxolone 0.000
Liraglutide 0.000
Heme 0.000
Novantrone 0.000
Pramipexole 0.000
Flavopiridol 0.000
Papaverine 0.000
Olmesartan 0.000
ISP 0.000
Emodin 0.000
Nitric Oxide 0.000
Cibacron Blue 0.000
Pramipexole 0.000
EHDP 0.000
Atovaquone 0.000
more...
Enzyme
complex I 1.000
NADH dehydrogenase 0.225
diaphorase 0.089
succinate dehydrogenase 0.015
cytochrome oxidase 0.006
ATP synthase 0.001
MPP 0.001
citrate synthase 0.001
CPR 0.001
aconitase 0.001
alpha-ketoglutarate dehydrogenase 0.000
ubiquinol-cytochrome c oxidoreductase 0.000
fumarate reductase 0.000
NQO1 0.000
succinic dehydrogenase 0.000
pyruvate dehydrogenase 0.000
malate dehydrogenase 0.000
ATPase 0.000
superoxide dismutase 0.000
transhydrogenase 0.000
pyruvate dehydrogenase 0.000
AMP-activated protein kinase 0.000
pyruvate dehydrogenase 0.000
hydrogenase 0.000
hydrogenase 0.000
oxaloacetate tautomerase 0.000
NADPH oxidase 0.000
catalase 0.000
EC 3.2.1.70 0.000
diaphorase 0.000
NADPH oxidase 0.000
isocitrate dehydrogenase 0.000
isocitrate dehydrogenase 0.000
AMPK 0.000
membrane-bound hydrogenase 0.000
sulfane sulfurtransferase 0.000
glycerol-3-phosphate dehydrogenase 0.000
glycerol-3-phosphate dehydrogenase 0.000
heterodisulfide reductase 0.000
OxdA 0.000
AMPK 0.000
malate oxidase 0.000
caspase-3 0.000
acyl-CoA dehydrogenase 0.000
EC 1.1.99.16 0.000
lactate dehydrogenase 0.000
NADPH-diaphorase 0.000
glutathione peroxidase 0.000
4-N-trimethylaminobutyraldehyde dehydrogenase 0.000
formate dehydrogenase 0.000
tyrosine hydroxylase 0.000
acyl-CoA dehydrogenase 0.000
bidirectional hydrogenase 0.000
fumarase 0.000
glycerol 3-phosphate dehydrogenase 0.000
thiosulfate dehydrogenase 0.000
formate dehydrogenase 0.000
formate dehydrogenase 0.000
pterin-4alpha-carbinolamine dehydratase 0.000
6-phosphogluconate dehydratase 0.000
glutathione reductase 0.000
glutaconyl-CoA decarboxylase 0.000
xanthine oxidase 0.000
proline dehydrogenase 0.000
NADH-cytochrome b5 reductase 0.000
NQO2 0.000
lactic acid dehydrogenase 0.000
monoamine oxidase 0.000
creatine kinase 0.000
lactate oxidase 0.000
lactic acid dehydrogenase 0.000
energy-linked transhydrogenase 0.000
KGOR 0.000
protein kinase 0.000
electron transfer flavoprotein dehydrogenase 0.000
BCKDH 0.000
succinyl-CoA synthetase 0.000
3-hydroxyacyl-CoA dehydrogenase 0.000
glycine dehydrogenase 0.000
glycine dehydrogenase 0.000
more...
Compound
NADH 0.013
ubiquinone 0.009
Rotenone 0.007
ubiquinol 0.002
NAD 0.001
oxygen 0.001
NAD 0.001
ATP 0.001
MPP 0.001
MPP 0.001
FMN 0.001
MPTP 0.001
CoQ 0.001
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 0.000
DNA 0.000
1-Methyl-4-phenylpyridinium 0.000
iron 0.000
ADP 0.000
ADP 0.000
ADP 0.000
succinic acid 0.000
Metformin 0.000
nicotinamide 0.000
Metformin 0.000
FAD 0.000
NADPH 0.000
NADPH 0.000
cyanide 0.000
Adriamycin aglycone 0.000
CoQ6 0.000
Decylubiquinone 0.000
H2O2 0.000
coenzyme Q10 0.000
4-phenylpyridine 0.000
glutamate 0.000
Bullatacin 0.000
TMPD 0.000
Ubisemiquinone 0.000
Antimycin 0.000
2-oxoglutarate 0.000
Fenpyroximate 0.000
GSH 0.000
GSH 0.000
Quinone 0.000
decyl 0.000
decyl 0.000
glucose 0.000
superoxide radical 0.000
Amytal 0.000
4'-Epiadriamycin 0.000
Syrosingopine 0.000
Rifamycin S 0.000
3,4-Dihydroxyphenylacetaldehyde 0.000
COX 0.000
FMNH 0.000
Xanthomegnin 0.000
4-chloroquinazoline 0.000
Ethylmalonic acid 0.000
Cytochrome c 0.000
NADP 0.000
hydrogen 0.000
Vitavax 0.000
Succinic acid monomethyl ester 0.000
Rapanone 0.000
AcPyAD 0.000
Tirandamycin 0.000
Rugulosin 0.000
Coenzyme Q10 0.000
Paraquat 0.000
ammonium 0.000
Duroquinone 0.000
heptyl 0.000
heptyl 0.000
1-benzyl-1,2,3,4-tetrahydroisoquinoline 0.000
Gracillin 0.000
Deguelin 0.000
N-acetylcysteine 0.000
Paraquat 0.000
DBI 0.000
L-Galactono-1,4-lactone 0.000
more...