Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.3 (complex I)
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Human Gene/Protein
NDUFS6 subunit 11.8
NDUFV2 protein 11.8
actin-related protein T2 11.8
transmembrane protein 126B 11.8
NDUFA7 11.8
NDUFS6 protein 11.8
NADH dehydrogenase 11.8
NADH-ubiquinone oxidoreductase 11.8
LYR motif containing 2 11.8
B14.5b 11.8
NADH-coenzyme Q reductase 11.8
KBTBD3 11.8
ATP5G 11.8
outer dense fiber protein 2 11.8
PRO1853 11.8
NUCM 11.8
MTND4L 11.8
EF-hand domain-containing protein 1 11.8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 11.8
LYRM3 11.8
PSST subunit 11.7
NDUFS7 11.7
TMEM126B 11.6
NDUFS6 11.5
NDUFS4 11.5
FOXRED1 11.5
NADH-ubiquinone reductase 11.5
NDUFAF1 11.4
complex I assembly factor 11.4
complex I) 11.4
ACAD9 protein 11.4
NDUFS5 11.4
TYKY 11.4
C20orf7 11.4
NADH-ubiquinone oxidoreductase chain 1 11.4
NDUFS8 11.4
NDUFS2 11.3
iron-sulfur protein 3 11.3
PSST 11.3
NDUFC2 11.3
NDUFS3 11.3
TMEM186 11.2
ACAD9 11.2
NDUFA1 11.2
NDUFB11 11.2
NDUFV3 11.1
NDUFAF2 11.1
NDUFAB1 11.1
TYKY subunit 11.1
NDUFA10 11.1
NADH: ubiquinone oxidoreductase 11.1
NDUFV1 11.1
NDUFS1 11.0
NUBPL 11.0
NDUFV2 11.0
MTND1 10.9
NADH dehydrogenase (ubiquinone) Fe-S protein 2 10.8
SGDH 10.8
zinc finger protein 432 10.8
MRS2L 10.8
NADH dehydrogenase III 10.8
C3orf1 10.8
GTP-binding protein SAR1 10.8
EARS2 protein 10.8
mitochondrial malate dehydrogenase 2, NAD 10.8
ATP5SL 10.8
angiopoietin-related protein 2 10.8
ATP1G1 10.8
Myosin light chain 3 10.8
CECR2B 10.8
progestin and adipoQ receptor family member III 10.8
sideroflexin 4 10.8
Matrilin 3 10.8
low molecular mass ubiquinone-binding protein 10.8
Ribosomal protein S18 10.8
dehydrogenase/reductase member 3 10.8
G8 protein 10.8
C1QL4 10.8
ATP synthase gamma chain 10.8
MTND2 10.8
more...
Disease
MTND6*LDYT14459A 11.8
early parkinson's 11.8
Infantile cardiomyopathy 11.8
Hereditary optic atrophy 11.8
Complex I deficiency 11.0
GOA1 10.8
Brisket disease 10.2
Hyper-beta-alaninemia 10.2
Metabolic myopathy 10.2
Disorders of mitochondrial metabolism 9.8
3-Hydroxyisobutyric aciduria 9.8
SCAE 9.8
Leber's hereditary optic neuropathy 9.3
Distal Myopathy 9.0
nanophyetiasis 9.0
LSFC 9.0
Leigh syndrome 9.0
CMT2K 8.8
Chromophobe cell renal carcinoma 8.6
MELAS 8.5
mitochondrial disease 8.4
mitochondrial encephalomyopathy 8.4
Fecal peritonitis 8.3
DEFECT 8.3
MELAS 8.3
SPG7 8.1
Neonatal anoxia 8.0
mitochondrial myopathy 7.9
MILS 7.7
PDH deficiency 7.6
SCA28 7.6
MERRF 7.4
HPA1 7.4
Fazio-Londe 7.3
Chronic progressive external ophthalmoplegia 7.3
EBSS 7.3
encephalomyelopathy 7.2
CMT4A 7.2
MNGIE 7.2
Pearson's syndrome 7.1
Diabetic encephalopathy 7.1
Kearns-Sayre syndrome 7.1
lactic acidosis 7.1
OPA1 7.0
PARK7 6.9
early onset schizophrenia 6.7
PARK6 6.7
Richner-Hanhart syndrome 6.7
Alpers 6.7
pediatric disorder 6.6
OPA3 6.6
Brown-Vialetto-Van Laere syndrome 6.6
Carotid body 6.5
Carotid body 6.5
Carotid body 6.5
optic atrophy 6.5
Barth syndrome 6.4
PARK1 6.4
Extrahepatic cholestasis 6.4
SPG20 6.4
sideroblastic anemia 6.4
residual schizophrenia 6.3
NEK1 6.3
Sepsis-associated encephalopathy 6.3
Mitochondrial DNA depletion 6.1
Wolcott-Rallison syndrome 6.0
Conduction disorders 6.0
NDI 6.0
RP9 5.8
audiogenic epilepsy 5.8
enzyme deficiency 5.7
Bergeron 5.6
harlequin 5.6
hyperornithinemia 5.6
Optic neuropathy 5.5
disorders of amino acid metabolism 5.5
Parkinson's disease 5.5
PARK8 5.5
CRD1 5.4
AN2 5.4
more...
Symptom
Respiration stimulated 10.8
External ophthalmoplegia 9.0
Exercise intolerance 7.3
Cold intolerance 5.7
hypotonia 5.2
ophthalmoplegia 5.0
adipsia 4.3
impaired motor coordination 4.2
Extrapyramidal symptoms 4.2
aphagia 4.2
dystonia 4.1
hyperoxia 4.0
athetosis 3.8
male subfertility 3.8
Decreased activity 3.7
visual hallucination 3.6
cerebellar ataxia 3.4
ataxia 3.3
hangover 3.3
myoclonus 3.2
bradykinesia 3.2
paraparesis 3.0
neurological disability 2.9
dysarthria 2.9
motor symptom 2.9
clumsiness 2.7
Anoxia 2.7
ketonuria 2.7
weakness 2.7
spasticity 2.6
collapse 2.6
drooling 2.4
starvation 2.4
consciousness disturbance 2.1
muscle cramps 2.0
chorea 1.8
emaciation 1.8
eds 1.8
cachexia 1.7
hepatomegaly 1.6
tremor 1.5
seizures 1.5
hypercapnia 1.4
hemiplegia 1.4
functional recovery 1.4
bitter taste 1.3
lethargy 1.3
hypothermia 1.3
despair 1.2
myalgia 1.1
enuresis 1.1
incoordination 1.0
exhaustion 0.9
fatigue 0.8
polydipsia 0.7
anorexia 0.6
vomiting 0.5
pallor 0.5
thinning 0.3
paresis 0.3
acidity 0.2
polyuria 0.2
bone pain 0.2
respiratory distress 0.1
exertional dyspnea 0.1
constipation 0.1
chills -0.3
hepatosplenomegaly -0.3
nausea -0.4
anesthesia -0.8
arthralgia -1.0
diarrhea -1.0
spasm -1.0
analgesia -1.4
nausea and vomiting -1.4
splenomegaly -1.5
insomnia -1.6
Ill -1.6
headache -1.6
sleepiness -1.8
more...
Drug
Nanaomycin D 10.2
Mubritinib 9.5
Haloperidol Decanoate 9.2
Duroquinone 9.2
Bupleurum root 8.6
NADH 8.0
Idebenone 7.9
Tuareg 7.2
7-Nitroindazole 6.9
Atabrine 6.9
URF 6.9
Secobarbital 6.5
Demerol 6.4
Parkin 6.3
Parkin 6.3
SMP 6.0
Epidoxorubicin 6.0
FAD 6.0
Demerol 5.8
Vinpocetine 5.6
Abamectin 5.6
ROX 5.6
ROS 5.5
Ciprofibrate 5.5
3,4-Dihydroxyphenylalanine 5.5
2-Methoxyestradiol 5.4
Flavin 5.4
Dronedarone 5.4
Sodium thiosulfate 5.2
Fipronil 5.1
Aricept 5.1
Paliperidone 5.1
Riboflavin 5.0
Flupenthixol 5.0
Sesamol 5.0
Ranolazine 4.8
Ranolazine 4.8
Vanilla 4.7
Florfenicol 4.6
Adenosine triphosphate 4.6
Rebamipide 4.6
Rasagiline 4.5
Isoniazid 4.5
Podophyllum 4.4
Guanidine 4.4
Guanidine 4.4
Atovaquone 4.4
Caspofungin 4.4
Tibolone 4.3
Agomelatine 4.3
SPP 4.2
Carbenoxolone 4.2
AGG 4.2
Novantrone 4.2
Pramipexole 4.1
Flavopiridol 4.1
Olmesartan 4.1
Methylene blue 4.1
Pramipexole 4.1
Liraglutide 4.0
Atovaquone 4.0
Papaverine 3.9
ISP 3.9
Simvastatin 3.9
Emodin 3.9
Cibacron Blue 3.9
EHDP 3.9
Desferal 3.8
Arsenic trioxide 3.8
Propidium 3.8
Photofrin II 3.8
ascorbate 3.8
Geranium 3.8
Fructose 3.7
Desferal 3.7
Bezafibrate 3.7
Clofibrate 3.7
Emodin 3.6
Glutathione 3.6
citric acid 3.6
more...
Enzyme
complex I 11.8
NADH dehydrogenase 11.8
diaphorase 10.4
EC 3.2.1.70 10.2
oxaloacetate tautomerase 10.0
sulfane sulfurtransferase 9.5
OxdA 9.2
ubiquinol-cytochrome c oxidoreductase 9.0
succinate dehydrogenase 8.9
EC 1.1.99.16 8.8
4-N-trimethylaminobutyraldehyde dehydrogenase 8.6
malate oxidase 8.6
pterin-4alpha-carbinolamine dehydratase 8.2
cytochrome oxidase 8.1
thiosulfate dehydrogenase 8.1
fumarate reductase 8.0
MPP 7.9
membrane-bound hydrogenase 7.8
heterodisulfide reductase 7.8
bidirectional hydrogenase 7.8
glutaconyl-CoA decarboxylase 7.8
alpha-ketoglutarate dehydrogenase 7.7
aconitase 7.5
6-phosphogluconate dehydratase 7.4
KGOR 7.3
energy-linked transhydrogenase 7.3
transhydrogenase 7.3
BCKDH 7.3
ADP-dependent glucokinase 7.1
glycine dehydrogenase 7.1
glycine dehydrogenase 7.1
electron transfer flavoprotein dehydrogenase 7.1
citrate synthase 7.0
glycerol 3-phosphate dehydrogenase 7.0
ATP synthase 6.9
succinic dehydrogenase 6.9
CPR 6.9
methylmalonyl-CoA epimerase 6.8
hydroxylamine reductase 6.8
hydroxylamine reductase 6.8
NQO2 6.5
ABA 8'-hydroxylase 6.5
isoflavone reductase 6.5
EC 1.1.1.39 6.4
glycine dehydrogenase 6.4
DHOdehase 6.4
thiosulfate dehydrogenase 6.4
proline dehydrogenase 6.3
m-AAA protease 6.3
dihydrodipicolinate reductase 6.2
NQO1 6.1
malate dehydrogenase 6.1
acylglycerol kinase 6.1
TUT 6.1
phospho-beta-glucosidase 6.1
acyl-CoA dehydrogenase 6.1
pyruvate dehydrogenase 6.1
3-hydroxybutyryl-CoA dehydrogenase 6.1
pyruvate dehydrogenase 6.1
lactate oxidase 6.1
oxoglutarate dehydrogenase 6.1
sarcosine dehydrogenase 6.0
pyruvate dehydrogenase 6.0
hydrogenase 6.0
lactic acid dehydrogenase 6.0
pyruvate:ferredoxin oxidoreductase 6.0
hydrogenase 6.0
succinyl-CoA synthetase 5.9
glycerol-3-phosphate dehydrogenase 5.9
lactic acid dehydrogenase 5.9
NADH-cytochrome b5 reductase 5.9
formate dehydrogenase 5.9
glycerol-3-phosphate dehydrogenase 5.9
diaphorase 5.9
formate dehydrogenase 5.9
formate dehydrogenase 5.9
acyl-CoA dehydrogenase 5.9
fumarase 5.8
Delta6-desaturase 5.8
cathepsin F 5.8
more...
Compound
Adriamycin aglycone 11.8
Ubisemiquinone 10.8
Decylubiquinone 10.5
Rotenone 9.9
Fenpyroximate 9.8
Syrosingopine 9.8
Rifamycin S 9.8
4'-Epiadriamycin 9.8
CoQ6 9.7
Bullatacin 9.7
4-chloroquinazoline 9.5
Xanthomegnin 9.5
Ethylmalonic acid 9.5
Rapanone 9.2
3,4-Dihydroxyphenylacetaldehyde 9.2
AcPyAD 9.2
Rugulosin 9.2
Tirandamycin 9.2
Succinic acid monomethyl ester 9.2
1-Methyl-4-phenylpyridinium 9.0
Gracillin 9.0
L-Galactono-1,4-lactone 8.8
Duroquinone 8.7
ubiquinone 8.7
Luteoskyrin 8.6
D-Carnitine 8.6
ubiquinol 8.5
Vitavax 8.5
Petasin 8.5
1,2,3-benzothiadiazole 8.5
Amdro 8.3
1-benzyl-1,2,3,4-tetrahydroisoquinoline 8.3
Squamocin 8.3
Quinalizarin 8.3
Sennoside A 8.3
Tetrahydroberberine 8.2
5-Methoxyindole 8.2
Tetrahydroberberine 8.2
Coproporphyrin III 8.1
NADH 8.0
C4H8O3 8.0
3-succinoylpyridine 8.0
Cubebin 8.0
CoQ 8.0
4-phenylpyridine 8.0
MPP 7.9
Bullatacin 7.9
2,2',5,5'-TCB 7.9
MPP 7.9
TMPD 7.9
Deguelin 7.8
Coproporphyrin III 7.8
1H-indazole-3-carboxylic acid 7.7
Di-n-butyltin dichloride 7.7
2,2,4-trimethyl-1,2-dihydroquinoline 7.6
Methacrylonitrile 7.6
Stigmatellin 7.6
Amytal 7.6
Dequalinium chloride 7.6
Adrenochrome 7.6
Pyrvinium 7.6
L-lactaldehyde 7.6
C5H5NO 7.5
Decursinol 7.5
Naphthazarin 7.5
D-Proline 7.4
FMN 7.4
Antimycin 7.2
Spartin 7.2
FMNH 7.2
Oxmetidine 7.2
Enniatin B 7.2
Sedoheptulose 7.2
Bilobalide 7.2
Glyceollin 7.1
Glyceollin 7.1
DBI 7.1
dichloropalladium 7.1
Phytanic acid 7.1
Nilutamide 7.0
more...