Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.6.5.3 (complex I)
8,901 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein NADH dehydrogenase 2018 NADH 1618 ATP 1154 Mol 866 ubiquinone 690 Sep 592 complex I) 498 NAD 450 cytochrome c 372 cytochrome c oxidase 360 oxidoreductase 309 NADH-ubiquinone oxidoreductase 292 cytochrome 282 reductase 281 ADP 274 ROS 251 superoxide dismutase 234 ATP synthase 228 B13 210 NADPH 203 catalase 202 ATPase 198 ND1 185 GSH 178 polypeptide 171 caspase-3 170 cytochrome b 169 NADH-ubiquinone reductase 166 tRNA 164 citrate synthase 162 membrane-bound 154 insulin 139 NAD+ 138 FMN 137 flavoprotein 136 ND4 131 ND5 130 EPR 125 MPP 117 endoplasmic reticulum 115 ND6 101 FAD 97 lactate dehydrogenase 93 malate dehydrogenase 87 glutathione peroxidase 87 MELAS 86 membrane protein 85 aconitase 84 alpha-synuclein 82 SDS 81 NDUFS4 78 AMP-activated protein kinase 75 ferredoxin 75 ND2 75 ND3 74 Bcl-2 74 tyrosine hydroxylase 72 OXPHOS 71 DT-diaphorase 71 nitric oxide synthase 69 quinone oxidoreductase 68 p53 68 SOD 67 pyruvate dehydrogenase 65 PGC 63 AMPK 63 alpha-ketoglutarate dehydrogenase 59 mTOR 59 ubiquitin 56 AMP 55 TNF 55 Chlamydomonas 54 creatine kinase 54 proteasome 54 MnSOD 53 Gen 50 NADP 50 NADH: ubiquinone oxidoreductase 50 CO2 48 glutathione reductase 46 more...

Disease Parkinson's disease 817 cancer 395 ischemia 240 tumor 234 Leigh syndrome 205 GSH 178 mitochondrial disease 176 Leber's hereditary optic neuropathy 161 lactic acidosis 161 diabetes 156 Alzheimer's disease 142 neuroblastoma 122 parkinsonism 112 stroke 108 cardiomyopathy 93 encephalopathy 90 type 2 diabetes 86 myopathy 82 SDS 81 mitochondrial myopathy 75 obesity 72 heart failure 68 epilepsy 57 optic atrophy 56 depression 54 cold 52 MELAS 52 tumorigenesis 51 breast cancer 50 neuropathy 50 mitochondrial encephalomyopathy 48 hepatocellular carcinoma 47 tumor growth 46 MELAS 46 sepsis 46 sepsis 46 schizophrenia 44 myocardial ischemia 44 Huntington's disease 42 dementia 41 carcinoma 41 hypertrophic cardiomyopathy 40 hypertension 39 tumor progression 38 amyotrophic lateral sclerosis 37 tuberculosis 36 hyperglycemia 36 pheochromocytoma 34 Complex I deficiency 34 leukemia 33 Mycobacterium 33 fatty liver 32 cognitive impairment 31 developmental delay 30 myocardial infarction 30 cerebral ischemia 25 carcinogenesis 25 Kearns-Sayre syndrome 25 bipolar disorder 24 OPA1 24 PCC 24 respiratory failure 24 cardiovascular disease 23 malnutrition 23 lung cancer 23 glioma 22 leukoencephalopathy 22 cholera 21 blindness 21 adenocarcinoma 21 enzyme deficiency 20 multiple sclerosis 20 Echinococcus 19 Friedreich's ataxia 19 worms 19 deafness 19 osteosarcoma 19 malaria 19 fits 18 dilated cardiomyopathy 18 more...

Symptom weakness 67 seizures 65 hypotonia 62 collapse 47 ataxia 44 dystonia 39 starvation 36 ophthalmoplegia 30 fatigue 25 hyperoxia 23 anesthesia 18 tremor 15 vomiting 13 hypothermia 12 cerebellar ataxia 11 myoclonus 11 spasticity 11 functional recovery 10 diarrhea 8 dysarthria 8 exhaustion 7 pain 6 paraparesis 6 hypercapnia 6 respiratory distress 6 bradykinesia 6 anorexia 6 Exercise intolerance 5 nausea 5 cachexia 5 acidity 5 headache 5 hepatomegaly 5 lethargy 4 thinning 4 myalgia 4 analgesia 3 hemiplegia 3 constipation 3 dyspnea 2 paresis 2 External ophthalmoplegia 2 neurological disability 2 overweight 2 chorea 2 Decreased activity 2 sleepiness 1 ketonuria 1 Anoxia 1 pallor 1 emaciation 1 enuresis 1 adipsia 1 Respiration stimulated 1 hepatosplenomegaly 1 arthralgia 1 consciousness disturbance 1 Ill 1 drooling 1 muscle cramps 1 clumsiness 1 chills 1 angina 1 motor symptom 1 insomnia 1 polydipsia 1 hangover 1 spasm 1 splenomegaly 1 nausea and vomiting 1 polyuria 1 athetosis 1 visual hallucination 1 impaired motor coordination 1 exertional dyspnea 1 Cold intolerance 1 aphagia 1 bone pain 1 male subfertility 1 bitter taste 1 more...

Drug NADH 1617 ROS 251 FAD 97 ascorbate 88 vitamin E 44 lysine 42 Parkin 42 Parkin 42 citric acid 33 THF 23 Gel 20 Cardiovasc 19 Glutathione 18 CSF 14 Adriamycin 13 Asn 12 DNase I 11 Indomethacin 11 Dermatol 9 Ethanol 9 Idebenone 8 Heme 7 Riboflavin 7 Simvastatin 7 SMP 7 Fructose 7 Adenosine triphosphate 6 Biopolymers 6 ICI 6 Vitamin E 6 Methylene blue 6 Nitric Oxide 6 Isoniazid 6 Propofol 5 caffeine 5 Glycerol 5 Angiotensin II 5 nitroglycerin 5 Leaf 5 AZT 5 niacin 5 AZT 5 ADM 5 lactose 5 MAP 5 Arsenic trioxide 5 IL-2 4 MRC 4 Imatinib 4 Frontal 4 AGG 4 Flavin 4 PCB 3 7-Nitroindazole 3 Mutagen 3 TTC 3 ABC 3 ALA 3 IFN-beta 3 p75 3 IFN-gamma 3 URF 3 NH3 3 Fipronil 3 TAT 3 ETS 3 balanced salt solution 3 PCP 3 Nephron 3 Ranolazine 2 Tacrolimus 2 Ranolazine 2 Apomorphine 2 Duroquinone 2 Cibacron Blue 2 CaCl2 2 Photofrin 2 Vinpocetine 2 CaCl2 2 2-Methoxyestradiol 2 more...

Enzyme complex I 8901 diaphorase 2164 NADH dehydrogenase 2067 succinate dehydrogenase 1057 cytochrome oxidase 696 ATPase 319 superoxide dismutase 302 ATP synthase 243 catalase 215 CPR 176 citrate synthase 166 AMP-activated protein kinase 127 MPP 122 NQO1 122 caspase-3 120 protein kinase 114 lactate dehydrogenase 104 mitogen-activated protein kinase 103 pyruvate dehydrogenase 98 NADPH oxidase 96 NADPH oxidase 91 malate dehydrogenase 89 glutathione peroxidase 89 aconitase 89 AMPK 76 alpha-ketoglutarate dehydrogenase 73 tyrosine hydroxylase 69 pyruvate dehydrogenase 66 pyruvate dehydrogenase 65 AMPK 63 hydrogenase 61 hydrogenase 61 succinic dehydrogenase 60 peroxidase 60 creatine kinase 56 proteasome 55 isocitrate dehydrogenase 47 glutathione reductase 47 isocitrate dehydrogenase 46 fumarate reductase 46 diaphorase 45 monoamine oxidase 42 xanthine oxidase 42 NADPH-diaphorase 37 glutathione S-transferase 35 ERK 35 transhydrogenase 32 protein kinase C 30 glycerol-3-phosphate dehydrogenase 30 glycerol-3-phosphate dehydrogenase 30 NO synthase 29 RNA polymerase 28 trypsin 28 caspase-9 28 aspartate aminotransferase 28 glyceraldehyde-3-phosphate dehydrogenase 27 PARP 25 alanine aminotransferase 25 glyceraldehyde-3-phosphate dehydrogenase 24 ubiquinol-cytochrome c oxidoreductase 24 acyl-CoA dehydrogenase 23 alcohol dehydrogenase 23 alkaline phosphatase 22 acetylcholinesterase 22 phosphatidylinositol 3-kinase 22 glyceraldehyde-3-phosphate dehydrogenase 21 aldehyde dehydrogenase 21 glyceraldehyde-3-phosphate dehydrogenase 21 luciferase 21 aldehyde dehydrogenase 20 aldehyde dehydrogenase 20 glyceraldehyde-3-phosphate dehydrogenase 20 aldehyde dehydrogenase 19 aldehyde dehydrogenase 19 pyruvate kinase 19 calcineurin 19 hexokinase 19 focal adhesion kinase 18 ACS 18 formate dehydrogenase 18 more...

Compound oxygen 2039 NADH 1615 DNA 1341 ATP 1154 ubiquinone 688 Dec 654 NAD 571 iron 541 glucose 472 NAD 450 hydrogen 332 calcium 319 ADP 291 glutamate 286 ADP 277 ADP 275 sodium 229 Rotenone 224 NADPH 203 NADPH 203 H2O2 193 phosphate 193 GSH 191 GSH 191 MPTP 186 water 185 nitric oxide 183 ubiquinol 179 nicotinamide 175 ammonium 173 cysteine 172 cyanide 161 FMN 143 MPP 117 MPP 117 Clin 109 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 107 nitrogen 103 FAD 98 ethanol 98 arginine 94 alanine 92 leucine 91 SDS 89 CoQ 89 tyrosine 85 potassium 83 2-oxoglutarate 82 succinic acid 82 serine 81 Metformin 79 Metformin 79 NADP 78 sulfate 77 CO2 76 His 74 methionine 73 galactose 72 N-acetylcysteine 68 glycerol 67 superoxide radical 66 acetate 66 nitrate 65 cAMP 63 copper 62 salt 60 pyridine 59 AMP 59 lysine 56 TNF 55 coenzyme Q10 53 glutamine 50 Cardiol 48 CoA 48 manganese 46 threonine 45 Triton X-100 44 COX 43 TCA 43 MTT 40 more...

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