Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.3 (complex I)
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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
NADH dehydrogenase 0.227
complex I) 0.043
NADH-ubiquinone oxidoreductase 0.033
NADH-ubiquinone reductase 0.015
NADH 0.013
ubiquinone 0.010
NDUFS4 0.007
B13 0.005
ND1 0.004
NADH: ubiquinone oxidoreductase 0.003
PSST 0.003
NDUFS3 0.003
NDUFS2 0.003
ND5 0.003
NADH-coenzyme Q reductase 0.003
NDUFV1 0.003
ND4 0.002
NDUFS1 0.002
cytochrome c oxidase 0.002
NDUFS7 0.002
PSST subunit 0.002
NDUFV2 0.002
NDUFS8 0.002
NDUFA1 0.002
ND6 0.002
NDUFB11 0.002
complex I assembly factor 0.002
NDUFAF1 0.002
ND3 0.001
oxidoreductase 0.001
MELAS 0.001
TYKY 0.001
GRIM-19 0.001
ACAD9 0.001
ATP synthase 0.001
NAD 0.001
ATP 0.001
NDUFA4 0.001
OXPHOS 0.001
NDUFS6 0.001
more...
Disease
Leigh syndrome 0.003
Leber's hereditary optic neuropathy 0.003
Complex I deficiency 0.002
mitochondrial disease 0.002
Parkinson's disease 0.001
lactic acidosis 0.001
mitochondrial myopathy 0.001
MELAS 0.001
MELAS 0.001
mitochondrial encephalomyopathy 0.001
GOA1 0.000
optic atrophy 0.000
early parkinson's 0.000
Infantile cardiomyopathy 0.000
MTND6*LDYT14459A 0.000
Hereditary optic atrophy 0.000
Kearns-Sayre syndrome 0.000
OPA1 0.000
parkinsonism 0.000
GSH 0.000
Brisket disease 0.000
Hyper-beta-alaninemia 0.000
Metabolic myopathy 0.000
Disorders of mitochondrial metabolism 0.000
3-Hydroxyisobutyric aciduria 0.000
SCAE 0.000
ischemia 0.000
SPG7 0.000
myopathy 0.000
MERRF 0.000
neuroblastoma 0.000
CMT2K 0.000
encephalopathy 0.000
LSFC 0.000
Distal Myopathy 0.000
nanophyetiasis 0.000
cardiomyopathy 0.000
PDH deficiency 0.000
PARK7 0.000
Chromophobe cell renal carcinoma 0.000
more...
Symptom
Respiration stimulated 0.000
hypotonia 0.000
External ophthalmoplegia 0.000
Exercise intolerance 0.000
ophthalmoplegia 0.000
dystonia 0.000
ataxia 0.000
weakness 0.000
hyperoxia 0.000
collapse 0.000
Cold intolerance 0.000
starvation 0.000
seizures 0.000
cerebellar ataxia 0.000
myoclonus 0.000
spasticity 0.000
dysarthria 0.000
adipsia 0.000
bradykinesia 0.000
impaired motor coordination 0.000
Extrapyramidal symptoms 0.000
aphagia 0.000
paraparesis 0.000
Decreased activity 0.000
athetosis 0.000
male subfertility 0.000
tremor 0.000
visual hallucination 0.000
fatigue 0.000
hangover 0.000
hypothermia 0.000
neurological disability 0.000
functional recovery 0.000
motor symptom 0.000
clumsiness 0.000
Anoxia 0.000
ketonuria 0.000
cachexia 0.000
hepatomegaly 0.000
hypercapnia 0.000
more...
Drug
NADH 0.013
ROS 0.000
FAD 0.000
Parkin 0.000
Parkin 0.000
Nanaomycin D 0.000
Idebenone 0.000
Duroquinone 0.000
Mubritinib 0.000
Haloperidol Decanoate 0.000
Bupleurum root 0.000
ascorbate 0.000
7-Nitroindazole 0.000
URF 0.000
SMP 0.000
Tuareg 0.000
Atabrine 0.000
citric acid 0.000
vitamin E 0.000
Secobarbital 0.000
Demerol 0.000
Riboflavin 0.000
Flavin 0.000
THF 0.000
Epidoxorubicin 0.000
Glutathione 0.000
Vinpocetine 0.000
Abamectin 0.000
Demerol 0.000
ROX 0.000
Adenosine triphosphate 0.000
2-Methoxyestradiol 0.000
Dronedarone 0.000
Fipronil 0.000
Isoniazid 0.000
Ciprofibrate 0.000
3,4-Dihydroxyphenylalanine 0.000
Adriamycin 0.000
Sodium thiosulfate 0.000
Simvastatin 0.000
more...
Enzyme
complex I 1.000
NADH dehydrogenase 0.225
diaphorase 0.089
succinate dehydrogenase 0.015
cytochrome oxidase 0.006
ATP synthase 0.001
MPP 0.001
citrate synthase 0.001
CPR 0.001
aconitase 0.001
alpha-ketoglutarate dehydrogenase 0.000
ubiquinol-cytochrome c oxidoreductase 0.000
fumarate reductase 0.000
NQO1 0.000
succinic dehydrogenase 0.000
pyruvate dehydrogenase 0.000
malate dehydrogenase 0.000
ATPase 0.000
superoxide dismutase 0.000
transhydrogenase 0.000
pyruvate dehydrogenase 0.000
AMP-activated protein kinase 0.000
pyruvate dehydrogenase 0.000
hydrogenase 0.000
hydrogenase 0.000
oxaloacetate tautomerase 0.000
NADPH oxidase 0.000
catalase 0.000
EC 3.2.1.70 0.000
diaphorase 0.000
NADPH oxidase 0.000
isocitrate dehydrogenase 0.000
isocitrate dehydrogenase 0.000
AMPK 0.000
membrane-bound hydrogenase 0.000
sulfane sulfurtransferase 0.000
glycerol-3-phosphate dehydrogenase 0.000
glycerol-3-phosphate dehydrogenase 0.000
heterodisulfide reductase 0.000
OxdA 0.000
more...
Compound
NADH 0.013
ubiquinone 0.009
Rotenone 0.007
ubiquinol 0.002
NAD 0.001
oxygen 0.001
NAD 0.001
ATP 0.001
MPP 0.001
MPP 0.001
FMN 0.001
MPTP 0.001
CoQ 0.001
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 0.000
DNA 0.000
1-Methyl-4-phenylpyridinium 0.000
iron 0.000
ADP 0.000
ADP 0.000
ADP 0.000
succinic acid 0.000
Metformin 0.000
nicotinamide 0.000
Metformin 0.000
FAD 0.000
NADPH 0.000
NADPH 0.000
cyanide 0.000
Adriamycin aglycone 0.000
CoQ6 0.000
Decylubiquinone 0.000
H2O2 0.000
coenzyme Q10 0.000
4-phenylpyridine 0.000
glutamate 0.000
Bullatacin 0.000
TMPD 0.000
Ubisemiquinone 0.000
Antimycin 0.000
2-oxoglutarate 0.000
more...