Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.3 (complex I)
 8,901 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
NDUFS6 protein 11.8
NUCM 11.8
EF-hand domain-containing protein 1 11.8
NADH-ubiquinone oxidoreductase 11.8
PRO1853 11.8
LYR motif containing 2 11.8
B14.5b 11.8
NDUFA7 11.8
NADH dehydrogenase 11.8
NDUFS6 subunit 11.8
KBTBD3 11.8
actin-related protein T2 11.8
NADH-coenzyme Q reductase 11.8
NDUFV2 protein 11.8
LYRM3 11.8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 11.8
transmembrane protein 126B 11.8
outer dense fiber protein 2 11.8
ATP5G 11.8
MTND4L 11.8
PSST subunit 11.7
NDUFS7 11.7
TMEM126B 11.6
NDUFS6 11.5
NDUFS4 11.5
FOXRED1 11.5
NADH-ubiquinone reductase 11.5
NDUFAF1 11.4
complex I assembly factor 11.4
complex I) 11.4
C20orf7 11.4
NADH-ubiquinone oxidoreductase chain 1 11.4
NDUFS5 11.4
TYKY 11.4
ACAD9 protein 11.4
NDUFS8 11.4
NDUFS2 11.3
iron-sulfur protein 3 11.3
PSST 11.3
NDUFC2 11.3
more...
Disease
MTND6*LDYT14459A 11.8
Hereditary optic atrophy 11.8
early parkinson's 11.8
Infantile cardiomyopathy 11.8
Complex I deficiency 11.0
GOA1 10.8
Metabolic myopathy 10.2
Brisket disease 10.2
Hyper-beta-alaninemia 10.2
3-Hydroxyisobutyric aciduria 9.8
SCAE 9.8
Disorders of mitochondrial metabolism 9.8
Leber's hereditary optic neuropathy 9.3
LSFC 9.0
nanophyetiasis 9.0
Distal Myopathy 9.0
Leigh syndrome 9.0
CMT2K 8.8
Chromophobe cell renal carcinoma 8.6
MELAS 8.5
mitochondrial disease 8.4
mitochondrial encephalomyopathy 8.4
DEFECT 8.3
Fecal peritonitis 8.3
MELAS 8.3
SPG7 8.1
Neonatal anoxia 8.0
mitochondrial myopathy 7.9
MILS 7.7
PDH deficiency 7.6
SCA28 7.6
MERRF 7.4
HPA1 7.4
Fazio-Londe 7.3
Chronic progressive external ophthalmoplegia 7.3
EBSS 7.3
encephalomyelopathy 7.2
MNGIE 7.2
CMT4A 7.2
Pearson's syndrome 7.1
more...
Symptom
Respiration stimulated 10.8
External ophthalmoplegia 9.0
Exercise intolerance 7.3
Cold intolerance 5.7
hypotonia 5.2
ophthalmoplegia 5.0
adipsia 4.3
impaired motor coordination 4.2
aphagia 4.2
Extrapyramidal symptoms 4.2
dystonia 4.1
hyperoxia 4.0
athetosis 3.8
male subfertility 3.8
Decreased activity 3.7
visual hallucination 3.6
cerebellar ataxia 3.4
ataxia 3.3
hangover 3.3
myoclonus 3.2
bradykinesia 3.2
paraparesis 3.0
neurological disability 2.9
dysarthria 2.9
motor symptom 2.9
clumsiness 2.7
Anoxia 2.7
ketonuria 2.7
weakness 2.7
spasticity 2.6
collapse 2.6
drooling 2.4
starvation 2.4
consciousness disturbance 2.1
muscle cramps 2.0
chorea 1.8
emaciation 1.8
eds 1.8
cachexia 1.7
hepatomegaly 1.6
more...
Drug
Nanaomycin D 10.2
Mubritinib 9.5
Haloperidol Decanoate 9.2
Duroquinone 9.2
Bupleurum root 8.6
NADH 8.0
Idebenone 7.9
Tuareg 7.2
7-Nitroindazole 6.9
Atabrine 6.9
URF 6.9
Secobarbital 6.5
Demerol 6.4
Parkin 6.3
Parkin 6.3
SMP 6.0
Epidoxorubicin 6.0
FAD 6.0
Demerol 5.8
Vinpocetine 5.6
Abamectin 5.6
ROX 5.6
ROS 5.5
Ciprofibrate 5.5
3,4-Dihydroxyphenylalanine 5.5
2-Methoxyestradiol 5.4
Flavin 5.4
Dronedarone 5.4
Sodium thiosulfate 5.2
Fipronil 5.1
Aricept 5.1
Paliperidone 5.1
Riboflavin 5.0
Flupenthixol 5.0
Sesamol 5.0
Ranolazine 4.8
Ranolazine 4.8
Vanilla 4.7
Florfenicol 4.6
Adenosine triphosphate 4.6
more...
Enzyme
complex I 11.8
NADH dehydrogenase 11.8
diaphorase 10.4
EC 3.2.1.70 10.2
oxaloacetate tautomerase 10.0
sulfane sulfurtransferase 9.5
OxdA 9.2
ubiquinol-cytochrome c oxidoreductase 9.0
succinate dehydrogenase 8.9
EC 1.1.99.16 8.8
4-N-trimethylaminobutyraldehyde dehydrogenase 8.6
malate oxidase 8.6
pterin-4alpha-carbinolamine dehydratase 8.2
cytochrome oxidase 8.1
thiosulfate dehydrogenase 8.1
fumarate reductase 8.0
MPP 7.9
membrane-bound hydrogenase 7.8
glutaconyl-CoA decarboxylase 7.8
bidirectional hydrogenase 7.8
heterodisulfide reductase 7.8
alpha-ketoglutarate dehydrogenase 7.7
aconitase 7.5
6-phosphogluconate dehydratase 7.4
KGOR 7.3
energy-linked transhydrogenase 7.3
transhydrogenase 7.3
BCKDH 7.3
glycine dehydrogenase 7.1
ADP-dependent glucokinase 7.1
glycine dehydrogenase 7.1
electron transfer flavoprotein dehydrogenase 7.1
citrate synthase 7.0
glycerol 3-phosphate dehydrogenase 7.0
ATP synthase 6.9
succinic dehydrogenase 6.9
CPR 6.9
hydroxylamine reductase 6.8
hydroxylamine reductase 6.8
methylmalonyl-CoA epimerase 6.8
more...
Compound
Adriamycin aglycone 11.8
Ubisemiquinone 10.8
Decylubiquinone 10.5
Rotenone 9.9
Syrosingopine 9.8
Rifamycin S 9.8
Fenpyroximate 9.8
4'-Epiadriamycin 9.8
CoQ6 9.7
Bullatacin 9.7
4-chloroquinazoline 9.5
Ethylmalonic acid 9.5
Xanthomegnin 9.5
Rapanone 9.2
AcPyAD 9.2
Rugulosin 9.2
Tirandamycin 9.2
3,4-Dihydroxyphenylacetaldehyde 9.2
Succinic acid monomethyl ester 9.2
1-Methyl-4-phenylpyridinium 9.0
Gracillin 9.0
L-Galactono-1,4-lactone 8.8
Duroquinone 8.7
ubiquinone 8.7
D-Carnitine 8.6
Luteoskyrin 8.6
ubiquinol 8.5
Vitavax 8.5
1,2,3-benzothiadiazole 8.5
Petasin 8.5
Quinalizarin 8.3
1-benzyl-1,2,3,4-tetrahydroisoquinoline 8.3
Squamocin 8.3
Amdro 8.3
Sennoside A 8.3
5-Methoxyindole 8.2
Tetrahydroberberine 8.2
Tetrahydroberberine 8.2
Coproporphyrin III 8.1
NADH 8.0
more...