Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.3 (
complex I
)
8,901
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
NADH dehydrogenase
2018
NADH
1618
ATP
1154
Mol
866
ubiquinone
690
Sep
592
complex I)
498
NAD
450
cytochrome c
372
cytochrome c oxidase
360
oxidoreductase
309
NADH-ubiquinone oxidoreductase
292
cytochrome
282
reductase
281
ADP
274
ROS
251
superoxide dismutase
234
ATP synthase
228
B13
210
NADPH
203
catalase
202
ATPase
198
ND1
185
GSH
178
polypeptide
171
caspase-3
170
cytochrome b
169
NADH-ubiquinone reductase
166
tRNA
164
citrate synthase
162
membrane-bound
154
insulin
139
NAD+
138
FMN
137
flavoprotein
136
ND4
131
ND5
130
EPR
125
MPP
117
endoplasmic reticulum
115
more...
Disease
Parkinson's disease
817
cancer
395
ischemia
240
tumor
234
Leigh syndrome
205
GSH
178
mitochondrial disease
176
Leber's hereditary optic neuropathy
161
lactic acidosis
161
diabetes
156
Alzheimer's disease
142
neuroblastoma
122
parkinsonism
112
stroke
108
cardiomyopathy
93
encephalopathy
90
type 2 diabetes
86
myopathy
82
SDS
81
mitochondrial myopathy
75
obesity
72
heart failure
68
epilepsy
57
optic atrophy
56
depression
54
MELAS
52
cold
52
tumorigenesis
51
breast cancer
50
neuropathy
50
mitochondrial encephalomyopathy
48
hepatocellular carcinoma
47
tumor growth
46
sepsis
46
sepsis
46
MELAS
46
schizophrenia
44
myocardial ischemia
44
Huntington's disease
42
dementia
41
more...
Symptom
weakness
67
seizures
65
hypotonia
62
collapse
47
ataxia
44
dystonia
39
starvation
36
ophthalmoplegia
30
fatigue
25
hyperoxia
23
anesthesia
18
tremor
15
vomiting
13
hypothermia
12
cerebellar ataxia
11
myoclonus
11
spasticity
11
functional recovery
10
dysarthria
8
diarrhea
8
exhaustion
7
hypercapnia
6
pain
6
bradykinesia
6
paraparesis
6
respiratory distress
6
anorexia
6
cachexia
5
nausea
5
Exercise intolerance
5
acidity
5
headache
5
hepatomegaly
5
lethargy
4
thinning
4
myalgia
4
analgesia
3
hemiplegia
3
constipation
3
External ophthalmoplegia
2
more...
Drug
NADH
1617
ROS
251
FAD
97
ascorbate
88
vitamin E
44
lysine
42
Parkin
42
Parkin
42
citric acid
33
THF
23
Gel
20
Cardiovasc
19
Glutathione
18
CSF
14
Adriamycin
13
Asn
12
Indomethacin
11
DNase I
11
Ethanol
9
Dermatol
9
Idebenone
8
Heme
7
Fructose
7
Simvastatin
7
Riboflavin
7
SMP
7
Vitamin E
6
ICI
6
Methylene blue
6
Adenosine triphosphate
6
Nitric Oxide
6
Biopolymers
6
Isoniazid
6
ADM
5
niacin
5
AZT
5
Leaf
5
lactose
5
MAP
5
Arsenic trioxide
5
more...
Enzyme
complex I
8901
diaphorase
2164
NADH dehydrogenase
2067
succinate dehydrogenase
1057
cytochrome oxidase
696
ATPase
319
superoxide dismutase
302
ATP synthase
243
catalase
215
CPR
176
citrate synthase
166
AMP-activated protein kinase
127
MPP
122
NQO1
122
caspase-3
120
protein kinase
114
lactate dehydrogenase
104
mitogen-activated protein kinase
103
pyruvate dehydrogenase
98
NADPH oxidase
96
NADPH oxidase
91
malate dehydrogenase
89
glutathione peroxidase
89
aconitase
89
AMPK
76
alpha-ketoglutarate dehydrogenase
73
tyrosine hydroxylase
69
pyruvate dehydrogenase
66
pyruvate dehydrogenase
65
AMPK
63
hydrogenase
61
hydrogenase
61
peroxidase
60
succinic dehydrogenase
60
creatine kinase
56
proteasome
55
isocitrate dehydrogenase
47
glutathione reductase
47
fumarate reductase
46
isocitrate dehydrogenase
46
more...
Compound
oxygen
2039
NADH
1615
DNA
1341
ATP
1154
ubiquinone
688
Dec
654
NAD
571
iron
541
glucose
472
NAD
450
hydrogen
332
calcium
319
ADP
291
glutamate
286
ADP
277
ADP
275
sodium
229
Rotenone
224
NADPH
203
NADPH
203
phosphate
193
H2O2
193
GSH
191
GSH
191
MPTP
186
water
185
nitric oxide
183
ubiquinol
179
nicotinamide
175
ammonium
173
cysteine
172
cyanide
161
FMN
143
MPP
117
MPP
117
Clin
109
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
107
nitrogen
103
FAD
98
ethanol
98
more...