Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.3 (complex I)
8,901 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
NADH dehydrogenase 2018
NADH 1618
ATP 1154
Mol 866
ubiquinone 690
Sep 592
complex I) 498
NAD 450
cytochrome c 372
cytochrome c oxidase 360
oxidoreductase 309
NADH-ubiquinone oxidoreductase 292
cytochrome 282
reductase 281
ADP 274
ROS 251
superoxide dismutase 234
ATP synthase 228
B13 210
NADPH 203
catalase 202
ATPase 198
ND1 185
GSH 178
polypeptide 171
caspase-3 170
cytochrome b 169
NADH-ubiquinone reductase 166
tRNA 164
citrate synthase 162
membrane-bound 154
insulin 139
NAD+ 138
FMN 137
flavoprotein 136
ND4 131
ND5 130
EPR 125
MPP 117
endoplasmic reticulum 115
more...
Disease
Parkinson's disease 817
cancer 395
ischemia 240
tumor 234
Leigh syndrome 205
GSH 178
mitochondrial disease 176
Leber's hereditary optic neuropathy 161
lactic acidosis 161
diabetes 156
Alzheimer's disease 142
neuroblastoma 122
parkinsonism 112
stroke 108
cardiomyopathy 93
encephalopathy 90
type 2 diabetes 86
myopathy 82
SDS 81
mitochondrial myopathy 75
obesity 72
heart failure 68
epilepsy 57
optic atrophy 56
depression 54
MELAS 52
cold 52
tumorigenesis 51
breast cancer 50
neuropathy 50
mitochondrial encephalomyopathy 48
hepatocellular carcinoma 47
tumor growth 46
sepsis 46
sepsis 46
MELAS 46
schizophrenia 44
myocardial ischemia 44
Huntington's disease 42
dementia 41
more...
Symptom
weakness 67
seizures 65
hypotonia 62
collapse 47
ataxia 44
dystonia 39
starvation 36
ophthalmoplegia 30
fatigue 25
hyperoxia 23
anesthesia 18
tremor 15
vomiting 13
hypothermia 12
cerebellar ataxia 11
myoclonus 11
spasticity 11
functional recovery 10
dysarthria 8
diarrhea 8
exhaustion 7
hypercapnia 6
pain 6
bradykinesia 6
paraparesis 6
respiratory distress 6
anorexia 6
cachexia 5
nausea 5
Exercise intolerance 5
acidity 5
headache 5
hepatomegaly 5
lethargy 4
thinning 4
myalgia 4
analgesia 3
hemiplegia 3
constipation 3
External ophthalmoplegia 2
more...
Drug
NADH 1617
ROS 251
FAD 97
ascorbate 88
vitamin E 44
lysine 42
Parkin 42
Parkin 42
citric acid 33
THF 23
Gel 20
Cardiovasc 19
Glutathione 18
CSF 14
Adriamycin 13
Asn 12
Indomethacin 11
DNase I 11
Ethanol 9
Dermatol 9
Idebenone 8
Heme 7
Fructose 7
Simvastatin 7
Riboflavin 7
SMP 7
Vitamin E 6
ICI 6
Methylene blue 6
Adenosine triphosphate 6
Nitric Oxide 6
Biopolymers 6
Isoniazid 6
ADM 5
niacin 5
AZT 5
Leaf 5
lactose 5
MAP 5
Arsenic trioxide 5
more...
Enzyme
complex I 8901
diaphorase 2164
NADH dehydrogenase 2067
succinate dehydrogenase 1057
cytochrome oxidase 696
ATPase 319
superoxide dismutase 302
ATP synthase 243
catalase 215
CPR 176
citrate synthase 166
AMP-activated protein kinase 127
MPP 122
NQO1 122
caspase-3 120
protein kinase 114
lactate dehydrogenase 104
mitogen-activated protein kinase 103
pyruvate dehydrogenase 98
NADPH oxidase 96
NADPH oxidase 91
malate dehydrogenase 89
glutathione peroxidase 89
aconitase 89
AMPK 76
alpha-ketoglutarate dehydrogenase 73
tyrosine hydroxylase 69
pyruvate dehydrogenase 66
pyruvate dehydrogenase 65
AMPK 63
hydrogenase 61
hydrogenase 61
peroxidase 60
succinic dehydrogenase 60
creatine kinase 56
proteasome 55
isocitrate dehydrogenase 47
glutathione reductase 47
fumarate reductase 46
isocitrate dehydrogenase 46
more...
Compound
oxygen 2039
NADH 1615
DNA 1341
ATP 1154
ubiquinone 688
Dec 654
NAD 571
iron 541
glucose 472
NAD 450
hydrogen 332
calcium 319
ADP 291
glutamate 286
ADP 277
ADP 275
sodium 229
Rotenone 224
NADPH 203
NADPH 203
phosphate 193
H2O2 193
GSH 191
GSH 191
MPTP 186
water 185
nitric oxide 183
ubiquinol 179
nicotinamide 175
ammonium 173
cysteine 172
cyanide 161
FMN 143
MPP 117
MPP 117
Clin 109
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 107
nitrogen 103
FAD 98
ethanol 98
more...