Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.3 (complex I)
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Human Gene/Protein
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 11.8
MTND4L 11.8
NADH-coenzyme Q reductase 11.8
actin-related protein T2 11.8
NDUFS6 protein 11.8
NUCM 11.8
NDUFA7 11.8
B14.5b 11.8
PRO1853 11.8
NADH-ubiquinone oxidoreductase 11.8
NDUFS6 subunit 11.8
NDUFV2 protein 11.8
EF-hand domain-containing protein 1 11.8
KBTBD3 11.8
ATP5G 11.8
NADH dehydrogenase 11.8
outer dense fiber protein 2 11.8
transmembrane protein 126B 11.8
LYR motif containing 2 11.8
LYRM3 11.8
more...
Disease
early parkinson's 11.8
Hereditary optic atrophy 11.8
MTND6*LDYT14459A 11.8
Infantile cardiomyopathy 11.8
Complex I deficiency 11.0
GOA1 10.8
Brisket disease 10.2
Hyper-beta-alaninemia 10.2
Metabolic myopathy 10.2
SCAE 9.8
Disorders of mitochondrial metabolism 9.8
3-Hydroxyisobutyric aciduria 9.8
Leber's hereditary optic neuropathy 9.3
Distal Myopathy 9.0
nanophyetiasis 9.0
LSFC 9.0
Leigh syndrome 9.0
CMT2K 8.8
Chromophobe cell renal carcinoma 8.6
MELAS 8.5
more...
Symptom
Respiration stimulated 10.8
External ophthalmoplegia 9.0
Exercise intolerance 7.3
Cold intolerance 5.7
hypotonia 5.2
ophthalmoplegia 5.0
adipsia 4.3
impaired motor coordination 4.2
Extrapyramidal symptoms 4.2
aphagia 4.2
dystonia 4.1
hyperoxia 4.0
athetosis 3.8
male subfertility 3.8
Decreased activity 3.7
visual hallucination 3.6
cerebellar ataxia 3.4
ataxia 3.3
hangover 3.3
myoclonus 3.2
more...
Drug
Nanaomycin D 10.2
Mubritinib 9.5
Duroquinone 9.2
Haloperidol Decanoate 9.2
Bupleurum root 8.6
NADH 8.0
Idebenone 7.9
Tuareg 7.2
7-Nitroindazole 6.9
Atabrine 6.9
URF 6.9
Secobarbital 6.5
Demerol 6.4
Parkin 6.3
Parkin 6.3
SMP 6.0
Epidoxorubicin 6.0
FAD 6.0
Demerol 5.8
Vinpocetine 5.6
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Enzyme
complex I 11.8
NADH dehydrogenase 11.8
diaphorase 10.4
EC 3.2.1.70 10.2
oxaloacetate tautomerase 10.0
sulfane sulfurtransferase 9.5
OxdA 9.2
ubiquinol-cytochrome c oxidoreductase 9.0
succinate dehydrogenase 8.9
EC 1.1.99.16 8.8
4-N-trimethylaminobutyraldehyde dehydrogenase 8.6
malate oxidase 8.6
pterin-4alpha-carbinolamine dehydratase 8.2
cytochrome oxidase 8.1
thiosulfate dehydrogenase 8.1
fumarate reductase 8.0
MPP 7.9
membrane-bound hydrogenase 7.8
glutaconyl-CoA decarboxylase 7.8
heterodisulfide reductase 7.8
more...
Compound
Adriamycin aglycone 11.8
Ubisemiquinone 10.8
Decylubiquinone 10.5
Rotenone 9.9
Syrosingopine 9.8
Rifamycin S 9.8
4'-Epiadriamycin 9.8
Fenpyroximate 9.8
CoQ6 9.7
Bullatacin 9.7
Ethylmalonic acid 9.5
4-chloroquinazoline 9.5
Xanthomegnin 9.5
Succinic acid monomethyl ester 9.2
Rugulosin 9.2
3,4-Dihydroxyphenylacetaldehyde 9.2
Tirandamycin 9.2
Rapanone 9.2
AcPyAD 9.2
1-Methyl-4-phenylpyridinium 9.0
more...