Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.6.5.3 (complex I)
8,901 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein NADH dehydrogenase 2018 NADH 1618 ATP 1154 Mol 866 ubiquinone 690 Sep 592 complex I) 498 NAD 450 cytochrome c 372 cytochrome c oxidase 360 oxidoreductase 309 NADH-ubiquinone oxidoreductase 292 cytochrome 282 reductase 281 ADP 274 ROS 251 superoxide dismutase 234 ATP synthase 228 B13 210 NADPH 203 catalase 202 ATPase 198 ND1 185 GSH 178 polypeptide 171 caspase-3 170 cytochrome b 169 NADH-ubiquinone reductase 166 tRNA 164 citrate synthase 162 membrane-bound 154 insulin 139 NAD+ 138 FMN 137 flavoprotein 136 ND4 131 ND5 130 EPR 125 MPP 117 endoplasmic reticulum 115 ND6 101 FAD 97 lactate dehydrogenase 93 glutathione peroxidase 87 malate dehydrogenase 87 MELAS 86 membrane protein 85 aconitase 84 alpha-synuclein 82 SDS 81 NDUFS4 78 AMP-activated protein kinase 75 ferredoxin 75 ND2 75 ND3 74 Bcl-2 74 tyrosine hydroxylase 72 DT-diaphorase 71 OXPHOS 71 nitric oxide synthase 69 p53 68 quinone oxidoreductase 68 SOD 67 pyruvate dehydrogenase 65 AMPK 63 PGC 63 mTOR 59 alpha-ketoglutarate dehydrogenase 59 ubiquitin 56 AMP 55 TNF 55 Chlamydomonas 54 creatine kinase 54 proteasome 54 MnSOD 53 NADP 50 NADH: ubiquinone oxidoreductase 50 Gen 50 CO2 48 glutathione reductase 46 isocitrate dehydrogenase 45 cytochrome aa3 43 synuclein 43 COX 43 Parkin 42 xanthine oxidase 42 proton pump 42 lipopolysaccharide 41 DJ-1 41 TCA 41 cytokine 40 peroxidase 40 MRI 40 caspase-9 40 acyl-CoA oxidase 39 NDUFS3 39 antioxidant enzyme 39 NMR 39 NDUFV1 39 parkin 38 apoptosis-inducing factor 38 tumor necrosis factor 38 ND4L 38 PSST 37 PINK1 37 threonine 36 NDUFS2 35 NDUFS1 35 TFAM 34 peroxisome proliferator-activated receptor 33 phosphorylating 33 Nrf2 33 fused 33 dimeric 33 mitochondrial transcription factor A 32 Cytochrome c 32 axonal 31 S protein 31 p38 31 JNK 31 pyruvate dehydrogenase complex 30 cytochrome bc1 30 NDUFV2 29 quinone reductase 29 MAPK 29 unknown function 29 inducible nitric oxide synthase 29 peroxisome proliferator-activated receptor gamma 28 PTEN 28 Pseudomonas 28 cox1 27 lipoamide dehydrogenase 27 UCP2 27 ERK1 27 manganese superoxide dismutase 26 heme oxygenase-1 26 aspartate aminotransferase 26 glutathione S-transferase 26 dopamine transporter 26 cytochrome c oxidase subunit I 26 GRIM-19 25 prohibitin 25 NADH-coenzyme Q reductase 25 MAO-B 25 NDUFA1 25 OPA1 24 COI 24 thioredoxin 23 NMDA receptor 23 SOD2 23 alkaline phosphatase 22 NDUFS8 22 collagen 22 SDHB 22 CA1 22 alcohol dehydrogenase 22 PARP 22 interferon 22 NQO1 22 microsomal 22 more...

Disease Parkinson's disease 817 cancer 395 ischemia 240 tumor 234 Leigh syndrome 205 GSH 178 mitochondrial disease 176 lactic acidosis 161 Leber's hereditary optic neuropathy 161 diabetes 156 Alzheimer's disease 142 neuroblastoma 122 parkinsonism 112 stroke 108 cardiomyopathy 93 encephalopathy 90 type 2 diabetes 86 myopathy 82 SDS 81 mitochondrial myopathy 75 obesity 72 heart failure 68 epilepsy 57 optic atrophy 56 depression 54 MELAS 52 cold 52 tumorigenesis 51 breast cancer 50 neuropathy 50 mitochondrial encephalomyopathy 48 hepatocellular carcinoma 47 MELAS 46 sepsis 46 sepsis 46 tumor growth 46 myocardial ischemia 44 schizophrenia 44 Huntington's disease 42 dementia 41 carcinoma 41 hypertrophic cardiomyopathy 40 hypertension 39 tumor progression 38 amyotrophic lateral sclerosis 37 hyperglycemia 36 tuberculosis 36 Complex I deficiency 34 pheochromocytoma 34 Mycobacterium 33 leukemia 33 fatty liver 32 cognitive impairment 31 developmental delay 30 myocardial infarction 30 cerebral ischemia 25 Kearns-Sayre syndrome 25 carcinogenesis 25 OPA1 24 respiratory failure 24 PCC 24 bipolar disorder 24 cardiovascular disease 23 malnutrition 23 lung cancer 23 glioma 22 leukoencephalopathy 22 blindness 21 cholera 21 adenocarcinoma 21 multiple sclerosis 20 enzyme deficiency 20 osteosarcoma 19 deafness 19 Echinococcus 19 Friedreich's ataxia 19 worms 19 malaria 19 dilated cardiomyopathy 18 fits 18 movement disorder 17 Klebsiella 17 HIV 17 progressive supranuclear palsy 17 prostate cancer 17 autism 16 lymphoma 16 glioblastoma 16 renal disease 16 Blocking 16 colorectal cancer 16 neurological disease 15 type 1 diabetes 15 atherosclerosis 15 muscular atrophy 15 hypoglycemia 14 failure to thrive 14 B-cell lymphoma 14 melanoma 14 MCF 14 status epilepticus 14 pancreatic cancer 13 metabolic syndrome 13 NAME 12 chronic obstructive pulmonary disease 12 photosensitivity 12 liver disease 12 metabolic disorder 12 metastases 12 catalepsy 12 diabetic nephropathy 11 anemia 11 Down syndrome 11 gastric cancer 11 immunodeficiency 11 AIDS 11 prolapse 11 renal cell carcinoma 10 West 10 Pineal 10 mental retardation 10 cystic fibrosis 10 glucose intolerance 10 MERRF 10 nystagmus 10 diabetic cardiomyopathy 10 ovarian cancer 10 sideroblastic anemia 9 non-small cell lung cancer 9 pulmonary hypertension 9 Fanconi 9 mental retardation 9 ATM 9 PARK7 9 major depressive disorder 9 hepatitis 9 infectious diseases 9 mental illness 8 colon cancer 8 aggressiveness 8 psychosis 8 mole 8 dehydration 8 alcoholic fatty liver 8 mole 8 leukodystrophy 8 iron deficiency 8 peripheral neuropathy 8 Schistosoma japonicum 8 acute myeloid leukemia 8 spastic paraplegia 7 squamous cell carcinoma 7 encephalomyelitis 7 PPR 7 brain edema 7 Chagas 7 myoclonus epilepsy 7 premature aging 7 hepatitis C 7 chronic hepatitis 7 more...

Symptom weakness 67 seizures 65 hypotonia 62 collapse 47 ataxia 44 dystonia 39 starvation 36 ophthalmoplegia 30 fatigue 25 hyperoxia 23 anesthesia 18 tremor 15 vomiting 13 hypothermia 12 cerebellar ataxia 11 myoclonus 11 spasticity 11 functional recovery 10 diarrhea 8 dysarthria 8 exhaustion 7 pain 6 paraparesis 6 hypercapnia 6 respiratory distress 6 bradykinesia 6 anorexia 6 Exercise intolerance 5 nausea 5 cachexia 5 acidity 5 headache 5 hepatomegaly 5 lethargy 4 thinning 4 myalgia 4 analgesia 3 hemiplegia 3 constipation 3 dyspnea 2 paresis 2 External ophthalmoplegia 2 neurological disability 2 overweight 2 chorea 2 Decreased activity 2 sleepiness 1 ketonuria 1 Anoxia 1 pallor 1 emaciation 1 enuresis 1 adipsia 1 Respiration stimulated 1 hepatosplenomegaly 1 arthralgia 1 consciousness disturbance 1 Ill 1 drooling 1 despair 1 clumsiness 1 chills 1 angina 1 motor symptom 1 insomnia 1 polydipsia 1 hangover 1 spasm 1 splenomegaly 1 nausea and vomiting 1 polyuria 1 athetosis 1 visual hallucination 1 impaired motor coordination 1 exertional dyspnea 1 Cold intolerance 1 muscle cramps 1 aphagia 1 bone pain 1 male subfertility 1 bitter taste 1 eds 1 Extrapyramidal symptoms 1 incoordination 1

Drug NADH 1617 ROS 251 FAD 97 ascorbate 88 vitamin E 44 lysine 42 Parkin 42 Parkin 42 citric acid 33 THF 23 Gel 20 Cardiovasc 19 Glutathione 18 CSF 14 Adriamycin 13 Asn 12 DNase I 11 Indomethacin 11 Ethanol 9 Dermatol 9 Idebenone 8 Heme 7 Simvastatin 7 Riboflavin 7 SMP 7 Fructose 7 Isoniazid 6 Biopolymers 6 Methylene blue 6 Vitamin E 6 Nitric Oxide 6 Adenosine triphosphate 6 ICI 6 Leaf 5 Angiotensin II 5 MAP 5 Arsenic trioxide 5 niacin 5 nitroglycerin 5 ADM 5 Glycerol 5 AZT 5 lactose 5 caffeine 5 Propofol 5 AZT 5 MRC 4 Frontal 4 Flavin 4 AGG 4 Imatinib 4 IL-2 4 PCB 3 Mutagen 3 balanced salt solution 3 Nephron 3 IFN-gamma 3 Fipronil 3 TAT 3 URF 3 ETS 3 IFN-beta 3 ABC 3 7-Nitroindazole 3 NH3 3 TTC 3 PCP 3 p75 3 ALA 3 Tacrolimus 2 Apomorphine 2 Ranolazine 2 Ranolazine 2 Sorafenib 2 Ranitidine 2 Duroquinone 2 ROX 2 Bayer 2 CaCl2 2 CaCl2 2 Glycyrrhiza 2 Vinpocetine 2 Fluorescein 2 Taxol 2 Photofrin 2 Guanidine 2 NBT 2 SPP 2 Papaverine 2 Liraglutide 2 Triclosan 2 Atenolol 2 Spectrum 2 ampicillin 2 Fluorescein 2 Abamectin 2 Honey 2 Spectrum 2 pyridoxal phosphate 2 Glucagon 2 Vitamin A 2 Emodin 2 Caspofungin 2 Rosiglitazone 2 Guanidine 2 Emodin 2 CTX 2 CaCl2 2 RFP 2 CIA 2 9-THC 2 2-Methoxyestradiol 2 Clofibrate 2 Monit 2 Cibacron Blue 2 ISP 2 Dronedarone 2 Fragment 2 Atabrine 2 Vitamin K 2 EHDP 2 Activin 1 Olmesartan 1 Demerol 1 ddI 1 Donepezil 1 BH4 1 Bupivacaine 1 Retinoic acid 1 Podophyllum 1 Bezafibrate 1 ZnCl2 1 Secobarbital 1 Artesunate 1 Geranium 1 ADR 1 Dasatinib 1 Sesamol 1 Gastro 1 PTC 1 DMI 1 Desferal 1 Haloperidol Decanoate 1 Pramipexole 1 NaI 1 AraC 1 Xanthium 1 Erlotinib 1 BLM 1 Rasagiline 1 Alliance 1 Demerol 1 3,4-Dihydroxyphenylalanine 1 Propidium 1 Histamine 1 IPM 1 Photofrin II 1 Iloprost 1 Tocopherol 1 Meth 1 more...

Enzyme complex I 8901 diaphorase 2164 NADH dehydrogenase 2067 succinate dehydrogenase 1057 cytochrome oxidase 696 ATPase 319 superoxide dismutase 302 ATP synthase 243 catalase 215 CPR 176 citrate synthase 166 AMP-activated protein kinase 127 NQO1 122 MPP 122 caspase-3 120 protein kinase 114 lactate dehydrogenase 104 mitogen-activated protein kinase 103 pyruvate dehydrogenase 98 NADPH oxidase 96 NADPH oxidase 91 malate dehydrogenase 89 glutathione peroxidase 89 aconitase 89 AMPK 76 alpha-ketoglutarate dehydrogenase 73 tyrosine hydroxylase 69 pyruvate dehydrogenase 66 pyruvate dehydrogenase 65 AMPK 63 hydrogenase 61 hydrogenase 61 peroxidase 60 succinic dehydrogenase 60 creatine kinase 56 proteasome 55 isocitrate dehydrogenase 47 glutathione reductase 47 fumarate reductase 46 isocitrate dehydrogenase 46 diaphorase 45 xanthine oxidase 42 monoamine oxidase 42 NADPH-diaphorase 37 ERK 35 glutathione S-transferase 35 transhydrogenase 32 protein kinase C 30 glycerol-3-phosphate dehydrogenase 30 glycerol-3-phosphate dehydrogenase 30 NO synthase 29 caspase-9 28 trypsin 28 aspartate aminotransferase 28 RNA polymerase 28 glyceraldehyde-3-phosphate dehydrogenase 27 alanine aminotransferase 25 PARP 25 glyceraldehyde-3-phosphate dehydrogenase 24 ubiquinol-cytochrome c oxidoreductase 24 acyl-CoA dehydrogenase 23 alcohol dehydrogenase 23 alkaline phosphatase 22 phosphatidylinositol 3-kinase 22 acetylcholinesterase 22 glyceraldehyde-3-phosphate dehydrogenase 21 luciferase 21 aldehyde dehydrogenase 21 glyceraldehyde-3-phosphate dehydrogenase 21 glyceraldehyde-3-phosphate dehydrogenase 20 aldehyde dehydrogenase 20 aldehyde dehydrogenase 20 hexokinase 19 pyruvate kinase 19 aldehyde dehydrogenase 19 calcineurin 19 aldehyde dehydrogenase 19 ACS 18 focal adhesion kinase 18 fumarase 18 carbonic anhydrase 18 formate dehydrogenase 18 reverse transcriptase 17 peroxiredoxin 17 glutamate dehydrogenase 16 glutamate dehydrogenase 16 glutamate dehydrogenase 16 formate dehydrogenase 16 caspase-8 16 nitrate reductase 16 nitrate reductase 16 phospholipase A2 16 nitrate reductase 16 formate dehydrogenase 16 acyl-CoA dehydrogenase 15 endonuclease 15 nitrate reductase 15 nitrate reductase 15 NOS 15 nitrate reductase 15 thioredoxin reductase 15 glucose-6-phosphate dehydrogenase 14 phosphoenolpyruvate carboxykinase 14 phosphoenolpyruvate carboxykinase 14 phosphoenolpyruvate carboxykinase 14 phosphofructokinase 13 PDK1 13 MEK 12 acid phosphatase 12 CPT 11 aldolase 10 acetyl-CoA carboxylase 10 guanylate cyclase 10 TPP 9 TPP 9 3-hydroxyacyl-CoA dehydrogenase 9 glucose dehydrogenase 9 heme oxygenase 9 enolase 9 DNA polymerase 9 GSK 9 NADH-cytochrome b5 reductase 9 nitrite reductase 8 nitrite reductase 8 phosphoinositide 3-kinase 8 ACE 8 lactic acid dehydrogenase 8 3-hydroxyacyl-CoA dehydrogenase 8 nitrite reductase 8 ferrochelatase 8 membrane-bound hydrogenase 8 DCF 8 nitrogenase 8 SCS 8 lactic acid dehydrogenase 8 TSP-1 7 dihydroorotate dehydrogenase 7 lactate oxidase 7 caspase-1 7 lactic acid dehydrogenase 7 phosphorylase 7 proline dehydrogenase 7 glycerol 3-phosphate dehydrogenase 7 succinyl-CoA synthetase 7 dihydroorotate dehydrogenase 7 RNase 7 RNase 7 SMP 7 beta-galactosidase 7 lipoxygenase 6 PDH 6 SOR 6 MMP 6 TOR 6 adrenodoxin reductase 6 5'-nucleotidase 6 thrombin 6 heterodisulfide reductase 6 lysozyme 6 transcriptase 5 more...

Compound oxygen 2039 NADH 1615 DNA 1341 ATP 1154 ubiquinone 688 Dec 654 NAD 571 iron 541 glucose 472 NAD 450 hydrogen 332 calcium 319 ADP 291 glutamate 286 ADP 277 ADP 275 sodium 229 Rotenone 224 NADPH 203 NADPH 203 H2O2 193 phosphate 193 GSH 191 GSH 191 MPTP 186 water 185 nitric oxide 183 ubiquinol 179 nicotinamide 175 ammonium 173 cysteine 172 cyanide 161 FMN 143 MPP 117 MPP 117 Clin 109 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 107 nitrogen 103 FAD 98 ethanol 98 arginine 94 alanine 92 leucine 91 SDS 89 CoQ 89 tyrosine 85 potassium 83 2-oxoglutarate 82 succinic acid 82 serine 81 Metformin 79 Metformin 79 NADP 78 sulfate 77 CO2 76 His 74 methionine 73 galactose 72 N-acetylcysteine 68 glycerol 67 superoxide radical 66 acetate 66 nitrate 65 cAMP 63 copper 62 salt 60 pyridine 59 AMP 59 lysine 56 TNF 55 coenzyme Q10 53 glutamine 50 CoA 48 Cardiol 48 manganese 46 threonine 45 Triton X-100 44 COX 43 TCA 43 MTT 40 Ile 38 THF 37 GSSG 36 Asp 33 tryptophan 33 Cytochrome c 32 zinc 32 tryptophan 32 tryptophan 32 tryptophan 32 hexadecyl 31 aldehyde 30 decyl 30 decyl 30 Adriamycin 30 pentose 26 pentose 26 pentose 26 MDA 26 bromide 26 pentose 26 COI 25 urea 25 isoleucine 24 isoleucine 23 proline 23 Coenzyme Q10 23 acetic acid 23 Cyt 23 Quinone 23 alcohol dehydrogenase 23 CCP 22 THF 22 ADP-ribose 22 L-DOPA 22 Melatonin 22 Mg2+ 22 valine 22 uridine 22 Paraquat 21 Paraquat 21 Resveratrol 21 adenylate 21 heptyl 21 heptyl 21 Antimycin 21 ADR 20 phosphocreatine 20 NMDA 20 methanol 19 iodine 19 hydroquinone 19 CAT 19 GTP 19 CAT 19 L-carnitine 19 CAT 19 cadmium 19 glutamic acid 18 TOF 18 NH2 18 Panam 17 silver 17 retinoic acid 17 aldehyde 17 diacetate 17 naphthoquinone 16 naphthoquinone 16 naphthoquinone 16 naphthoquinone 16 nickel 16 PEG 16 Lactate 16 ACS 16 naphthoquinone 16 naphthoquinone 16 EDTA 16 naphthoquinone 16 quinazoline 16 ACS 16 more...

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