Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.3 (complex I)
 8,901 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ALI1 gene product in Candida maltosa was previously shown to be essential for n-alkane assimilation, possibly as a transcription factor [Hwang et al., Gene 106 (1991) 61-69]. We show that the predicted sequence is highly homologous to a subunit of respiratory complex I from another fungus, Neurospora crassa, and from Bos taurus. The predicted protein contains a motif conserved in this subunit from mitochondria, chloroplasts and bacteria. It also contains an N-terminal sequence that suggests a mitochondrial (mt) localization and a role for mt respiration in n-alkane assimilation.
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PMID:The alkane-inducible Candida maltosa ALI1 gene product is an NADH:ubiquinone oxidoreductase subunit homologue. 829 70