Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.3 (
complex I
)
8,901
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neuronal cell death is accompanied by mitochondrial dysfunction with mitochondrial maintenance critical to neuronal survival. The
mitochondrial ubiquitin ligase
MARCH5
has dual roles in the upkeep of mitochondrial function.
MARCH5
is involved in targeted degradation of proteins harmful to mitochondria and impacts mitochondrial morphology upstream of the fission protein Drp1. In a neuronal cell model, dominant-negative
MARCH5
prevents mitochondrial fragmentation during neurodegenerative stress induced by the neuron-specific reactive oxygen generator 6-hydroxydopamine, the
complex I
inhibitor rotenone or Alzheimer's-related amyloid beta peptide. In addition, preservation of mitochondrial function in terms of membrane potential and lower reactive oxygen generation was observed following inactivation of
MARCH5
. Our findings connect
MARCH5
to neuronal stress responses and further emphasize the link between mitochondrial dynamics and function.
...
PMID:MARCH5 inactivation supports mitochondrial function during neurodegenerative stress. 2413 12
