Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.2 (NQO1)
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Human Gene/Protein
diaphorase 12.3
hydroxysteroid (17-beta) dehydrogenase 2 12.3
quinone reductase 12.3
CRYZL1 12.3
gamma-glutamylcysteine synthetase light subunit 12.3
TIGD1 12.3
CGI-49 12.3
NQO1 12.3
NQO1 protein 12.1
DT-diaphorase 11.9
QR1 11.8
NQO2 11.5
putative carbonyl reductase 11.3
KLHDC8A 11.3
hBR-STL-1 11.3
Diaphorase 11.3
QR2 11.2
NRH:quinone oxidoreductase 2 11.1
MRGPRX3 10.7
mitochondrial ribosomal protein L19 10.7
RNFT2 10.7
UDP glucuronosyltransferase 1 family, polypeptide A1 10.7
quinone oxidoreductase 10.7
glutamate-cysteine ligase modifier subunit 10.7
aflatoxin B1-aldehyde reductase 10.6
GCLM 10.6
GCLC 10.6
sulfotransferase 1C1 10.3
70kD) 10.3
TMCC3 10.3
PP4R4 10.3
GLCLR 10.1
HS3ST3A1 10.0
IRP protein 10.0
SLC31A2 10.0
SQRDL 10.0
P22PHOX 10.0
DTD 10.0
TALDO 9.7
HEP27 9.7
METTL7B 9.7
CX31 9.7
B3GNT6 9.7
DIA1 9.7
glutamate-cysteine ligase 9.6
SRXN1 9.6
PANK3 9.5
CRYZ 9.5
hPMC2 9.5
TP53I11 9.5
neuronal tropomodulin 9.5
glutathione S-transferase M4 9.5
HMOX1 9.5
EPHX1 9.4
NADH2 9.4
PGR5 9.4
P35B 9.3
heme oxygenase (decycling) 1 9.3
solute carrier family 19 member 1 9.3
VKORC1L1 9.3
novel reductase 1 9.3
HYOU1 9.3
glutathione S-transferase A1 9.2
NADH diaphorase 9.2
GluR4c 9.2
protein inhibitor of neuronal nitric oxide synthase 9.2
GPX1 protein 9.2
DDX24 9.2
protein TIP 9.2
CARS2 9.2
NMO1 9.1
GSTA1 9.1
Oxidoreductase 9.1
GNGT1 9.0
STARD6 9.0
TXNRD1 8.9
NF-E2-related factor 2 8.9
CALCRL 8.9
PTP4A2 8.9
LC8a 8.9
more...
Disease
Therapy-related acute myeloid leukemia and myelodysplastic syndrome 10.3
DTD 9.6
Squamous Cell Cancer 8.7
Stenotrophomonas maltophilia infection 8.2
CTPA 8.1
vitamin B deficiency 7.8
Lissauer 7.2
Bordetella infection 7.2
urinary system cancer 7.1
Persistent pulmonary hypertension 6.9
pediatric liver cancer 6.9
Myelodysplastic Syndrome 6.9
DIA 6.8
Reflux nephropathy 6.8
chemical carcinogenesis 6.7
influenzal pneumonia 6.6
XPD 6.2
ARP1 6.2
SAMS 6.1
CGD 6.1
Ileum 6.1
BPSD 6.1
Epididymis 6.1
Epididymis 6.1
erythrasma 6.1
hypoprothrombinemia 6.0
stage I breast cancer 6.0
cerebral hematoma 6.0
pinguecula 5.9
environmental carcinogenesis 5.9
bovine leukemia 5.9
MD1 5.8
adult brain tumor 5.8
GSH 5.8
cardiosclerosis 5.7
Intrahepatic cholestasis 5.7
Microangiopathy 5.7
AIN 5.7
CBS deficiency 5.7
Klebs 5.6
Chronic progressive external ophthalmoplegia 5.5
pediatric HD 5.4
Krabbe disease 5.4
favism 5.3
PARK7 5.3
Prostatitis 5.2
methemoglobinemia 5.2
keratocyst 5.1
SGS 5.1
PFD 5.1
Retinal ischemia 5.1
circulatory disorder 5.1
XPG 5.0
lymphoblastoma 5.0
Aeromonas hydrophila infection 5.0
Farber 5.0
alcoholic cardiomyopathy 5.0
carcinoma of the tongue 5.0
Spinal cord ischemia 4.9
PCC 4.9
DMT1 4.9
childhood ALL 4.9
Alveolar echinococcosis 4.8
HBT 4.8
AML/MDS 4.8
Reactive arthritis 4.8
SGS 4.8
hepatoblastoma 4.7
Choroid 4.7
Choroid 4.7
kidney tumor 4.7
PAPA 4.7
Burnett 4.6
Bardet-Biedl syndrome 4.6
carcinogenesis 4.5
Selenium deficiency 4.5
Ototoxicity 4.5
diabetic hyperglycemia 4.5
skin tumor 4.5
acrocyanosis 4.5
more...
Symptom
Involuntary Movement 4.7
disturbed balance 4.5
ACHE 4.5
hyperoxia 4.4
Decreased activity 3.3
ketonuria 3.2
menopausal symptoms 2.7
dry eye 2.6
orofacial pain 2.4
dry skin 2.3
eds 2.3
hot flashes 2.3
urinary frequency 2.2
abnormal gait 2.2
nasal congestion 2.2
pallor 2.0
tachypnea 2.0
Mills 2.0
chronic constipation 2.0
fasciculation 2.0
tonic-clonic seizure 2.0
hepatomegaly 1.8
anosmia 1.8
functional recovery 1.6
memory loss 1.5
twitching 1.3
masculinization 1.0
starvation 0.9
thinning 0.9
ophthalmoplegia 0.6
cyanosis 0.5
acidity 0.4
exhaustion 0.2
acute stress 0.2
respiratory distress 0.1
constipation 0.0
seizures -0.1
cachexia -0.1
lethargy -0.1
fatigue -0.2
hypothermia -0.2
hypotonia -0.2
hemoptysis -0.3
spasticity -0.3
myalgia -0.4
anorexia -0.4
arthralgia -0.5
ataxia -0.6
dystonia -0.7
pain -0.7
weakness -0.9
collapse -0.9
diarrhea -0.9
vomiting -1.0
nausea -1.2
agitation -1.2
anesthesia -1.3
sleepiness -1.3
erythema -1.4
stigma -1.4
dyspnea -1.4
analgesia -1.5
overweight -2.4
headache -2.4
abdominal pain -2.6
Drug
BZQ 10.5
Duroquinone 9.7
Cocarboxylase 9.5
Apaziquone 9.5
Fidarestat 8.5
Fidarestat 8.5
Equilenin 8.2
Motexafin gadolinium 7.6
NADH 7.5
Atabrine 7.4
Idebenone 7.4
Vitamin K 7.3
FAD 7.1
Ciprofibrate 7.0
Ponalrestat 6.9
Benzofuran 6.7
Solon 6.7
Coal tar 6.4
Dextran sulfate sodium 6.3
Malarone 6.3
Flavin 6.2
Cibacron Blue 6.2
Ramelteon 6.0
Tirapazamine 5.9
Phenprocoumon 5.8
Valproic Acid 5.8
Compound 16 5.6
Sesamol 5.5
Safflower 5.4
Compound 15 5.4
Trypanothione 5.4
Tannic acid 5.3
ROS 5.3
Roflumilast 5.3
Roflumilast 5.3
Rutin 5.3
Podophyllotoxin 5.2
Vanilla 5.2
Heme 5.2
Premarin 5.1
Dithranol 5.1
Nitazoxanide 5.0
Fenbendazole 5.0
NBT 5.0
Podophyllum 5.0
Bexarotene 4.9
Glutathione 4.9
Vardenafil 4.9
Arsenic trioxide 4.8
Artemether 4.8
Novantrone 4.7
Ethylenediamine 4.6
Trifluoperazine 4.5
Atovaquone 4.5
PE2 4.5
Glycyrrhiza 4.4
Emodin 4.4
Primaquine 4.4
Desferal 4.4
CDX 4.3
Photofrin II 4.3
Geranium 4.3
Desferal 4.2
Furan 4.2
Salicylate 4.2
Emodin 4.2
DEX 4.1
Photofrin 4.1
Myricetin 4.1
Kainic acid 4.0
Nitric Oxide 4.0
Rimonabant 4.0
CDX 3.9
BH4 3.8
SMP 3.7
Natalizumab 3.7
Riboflavin 3.7
GEO 3.7
Cilostazol 3.6
ascorbate 3.6
more...
Enzyme
4NQO reductase 12.3
malate-lactate transhydrogenase 12.3
NQO1 12.3
diaphorase 11.8
asparagusate dehydrogenase 11.3
NADPH-diaphorase 11.3
NQO2 11.1
quercetin 3-O-methyltransferase 10.7
diaphorase 10.7
vitamin K epoxidase 10.4
EC 1.1.1.108 10.3
p-benzoquinone reductase 10.0
12alpha-hydroxysteroid dehydrogenase 10.0
NADPH:quinone oxidoreductase 9.9
D-sorbitol dehydrogenase 9.5
bidirectional hydrogenase 9.3
thiosulfate dehydrogenase 9.2
ferric leghemoglobin reductase 9.0
N,O-acetyltransferase 9.0
NADH-cytochrome b5 reductase 8.9
NAD+ synthetase 8.8
4-hydroxyproline 2-epimerase 8.7
adrenodoxin reductase 8.6
4-nitrophenol hydroxylase 8.6
gamma-glutamylcysteine synthetase 8.4
4-hydroxybutyrate dehydrogenase 8.3
nicotinic acid hydroxylase 8.1
glutathione oxidase 8.0
2-nitropropane dioxygenase 7.9
D-galactose dehydrogenase 7.9
acylcarnitine hydrolase 7.9
thiosulfate dehydrogenase 7.9
energy-linked transhydrogenase 7.9
dihydrodipicolinate reductase 7.7
microsomal epoxide hydrolase 7.7
dihydrodiol dehydrogenase 7.7
hydroxyprostaglandin dehydrogenase 7.7
allantoate amidohydrolase 7.7
benzaldehyde dehydrogenase 7.7
benzaldehyde dehydrogenase 7.7
sulfur reductase 7.7
myrosinase 7.6
carbonyl reductase 7.6
heme oxygenase 7.5
flavin reductase 7.5
chorismate synthase 7.5
3beta-HSDH 7.5
ECH 7.3
heterodisulfide reductase 7.3
EC 1.1.1.47 7.3
dCTP deaminase 7.2
NADH dehydrogenase 7.1
putrescine oxidase 7.1
beta-hydroxybutyrate dehydrogenase 7.1
cysteine synthase 7.0
isoflavone reductase 7.0
dCTP deaminase 7.0
nicotinamide adenine dinucleotide glycohydrolase 7.0
azoreductase 7.0
tryptophan aminotransferase 7.0
NAD+ kinase 6.9
ubiquinol-cytochrome c oxidoreductase 6.9
succinic dehydrogenase 6.9
CPR 6.9
glutathione S-transferase 6.9
fumarate reductase 6.8
UDP-glucuronosyltransferase 6.8
soluble epoxide hydrolase 6.8
dihydroneopterin aldolase 6.7
glutathione reductase 6.7
EC 1.7.7.1 6.7
glycine reductase 6.7
transhydrogenase 6.7
aryl hydrocarbon hydroxylase 6.7
glycerol-3-phosphate oxidase 6.6
FTR 6.5
aldehyde reductase 6.5
aldehyde reductase 6.5
fructose-6-phosphate phosphoketolase 6.5
LGT 6.5
more...
Compound
Ixocarpalactone A 12.3
S-Methylisothiourea sulfate 12.3
Optochin hydrochloride 12.3
Vitamin K hydroquinone 11.3
C10H11N 11.3
C11H8N2O2 11.3
C14H10O3 11.3
Asparagusate 11.3
CB 1954 11.2
1-bromoheptane 10.9
3-Nitrofluoranthene 10.7
Lavendamycin 10.7
2,3-dihydroxypropanoic acid 10.7
2,3-dimethoxynaphthoquinone 10.7
2,3-dihydroxypropanoic acid 10.7
Aureusidin 10.3
5,10-dihydroindeno[1,2-b]indole 10.3
Dunnione 10.2
spirost-5-en-3-ol 10.0
4-nitroso-1-naphthol 10.0
Menadiol 10.0
CoQ4 10.0
C11H8O3 10.0
beta-Lapachone 9.8
11H-benzo[b]fluoren-11-one 9.7
Trichloropropene oxide 9.7
AZR 9.6
BHC 9.5
6,7-dichloro-5,8-quinolinedione 9.5
TNBT 9.4
4-amino-1-naphthol 9.4
Farrerol 9.3
Aurofusarin 9.3
C15H14O3 9.3
Duroquinone 9.2
CoQ6 9.2
Oltipraz 9.2
DL-alpha-Lipoic acid 9.2
Nomilin 9.0
AZQ 8.8
Bruceine D 8.7
4-ethoxybenzoic acid 8.7
Glucoraphanin 8.7
Cyanidin 3-O-beta-D-glucoside 8.6
Ethyl gallate 8.6
Quinone 8.6
NMOR 8.6
Metanil yellow 8.6
Obacunone 8.5
Diisodecyl phthalate 8.5
dihydrolipoamide 8.5
Vitavax 8.5
Cyclobenzaprine 8.4
2-tert-butyl-4-methylphenol 8.3
Isoorientin 8.3
Cyclocytidine 8.3
2-Nitroimidazole 8.3
Porfiromycin 8.3
Cycloartenol 8.3
Ferredoxin 8.3
1,2,3,4-TCDD 8.2
Isoprothiolane 8.2
Resorufin 8.2
Epiandrosterone 8.2
Phenanthrenequinone 8.1
nicotinamide 8.1
Naphthazarin 8.1
Benzanthrone 8.1
p-Nitrobenzoic acid 8.1
NAD 8.1
1,2,4-benzotriazine 8.0
7-Ethoxyresorufin 8.0
C5H5NO 8.0
Naphthazarin 8.0
Rutaecarpine 8.0
Sulforaphane 8.0
Musk ambrette 7.9
Rutaecarpine 7.9
Equilenin 7.9
Diallyl sulfide 7.9
more...