Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.2 (
NQO1
)
6,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Protein inhibitor of neuronal nitric oxide synthase
(
PIN
) is reported as the protein inhibiting neuronal nitric oxide synthase (nNOS) activity by preventing dimerization of nNOS. It was also reported that
PIN
inhibits the activity of all nitric oxide synthase (NOS) isozymes. We examined the effects of facial nerve transection on
PIN
mRNA and NOS expression by in situ hybridization for
PIN
mRNA and nicotinamide adenine dinucleotide phosphate
diaphorase
(NADPH-d) staining.
PIN
mRNA was initially expressed and transiently increased from 3 to 5 days and returned to the basal level at 7 days after axotomy in the motoneurons of the facial nucleus. NADPH-d-positive motoneurons were found from 7 days post-operation in the facial nucleus. These results suggest that
PIN
may interact with NOS from 7 days post-operation.
...
PMID:Changes in mRNA of protein inhibitor of neuronal nitric oxide synthase following facial nerve transection. 1069 46
