Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.6.5.2 (NQO1)
 6,196 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new subdivision, the "marginal division" (MrD), was discovered at the caudal border of the striatum and surrounds the rostral edge of the globus pallidus in the rat brain in our previous studies. The neuronal somata of the MrD are mostly fusiform in shape with their long axes lining dorsoventrally. The MrD is more densely filled with substance P (SP)-, Leucine-enkephalin (L-Enk)-, dynorphin B-, neurotensin-, somatostatin- and cholecystokinin (CCK)-immunoreactive fibers and terminal-like structures than the rest of the striatum. The MrD was confirmed in the cat neostriatum as well. The present study intended to explore whether the MrD exists in the monkey neostriatum (putamen) with Nissl, histochemical and immunohistochemical methods. A band of fusiform neurons were obviously identified at the caudomedial edge of the putamen. These neurons lie outside the lateral medullary lamina and indirectly surround the rostrolateral border of the globus pallidus. The abundance of SP-, L-Enk-, neuropeptide Y-, CCK-, dopamine- and serotonin-positive fibers and terminal-like structures with a few positive fusiform neurons accumulating at the caudomedial border of the putamen obviously distinguishes this zone from the rest of neostriatum and globus pallidus. The acetylcholinesterase (AChE) positive and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) containing fusiform neurons are distinctly visualized in the same zone. The morphological figure and the location of these neurons, and the histochemical and immunohistochemical characteristics of this area coincide well with those of the MrD in the rat and cat striatum. This study thus convincingly identifies the existence of the MrD in the monkey neostriatum. It is fairly asserted that the MrD is a universal structure in the mammalian brain.
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PMID:A new subdivision, marginal division, in the neostriatum of the monkey brain. 1078 7

Recent studies have greatly increased our knowledge of telencephalic organization in ray-finned fishes and terrestrial vertebrates, particularly amphibians. In contrast, little new information has been generated on telencephalic organization in lobe-finned fishes. The coelacanth, Latimeria, and three genera of lungfishes constitute the living lobe-finned fishes. Latimeria is extremely rare and critically endangered, so the living lungfishes, therefore, offer the only feasible source of new information on telencephalic organization in lobe-finned fishes. A re-examination of the cytoarchitectonics of the telencephalon in the Spotted African Lungfish has allowed the generation of a new model of telencephalic organization in lungfishes. To begin to test this model, examination was made of the telencephalic distribution of acetylcholinesterase, enkephalin, the neurotensin-related hexapeptide LANT6, nitric oxide synthase (nicotinamide adenine dinucleotide phosphate-diaphorase), substance P, and tyrosine hydroxylase. This distribution supports the new model and suggests that the medial pallial-subpallial border, the striatopallidal systems, and the amygdalar organization in this lungfish are more similar to these features in terrestrial vertebrates than was previously suspected.
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PMID:Telencephalic organization in the spotted African Lungfish, Protopterus dolloi: a new cytological model. 1924 96