Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.2 (
NQO1
)
6,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C,
Porfiromycin
, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol). Sensitivity has been compared with the intra-cellular levels of
DT-diaphorase
, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of
DT-diaphorase
and sensitivity to Mitomycin C or
Porfiromycin
. However, for EO9 those cell lines showing highest levels of
DT-diaphorase
activity tend to be the most sensitive.
...
PMID:The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase? 151 Jun 92
