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Query: EC:1.6.5.2 (
NQO1
)
6,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of
Metanil yellow
, Orange II and their blend on hepatic xenobiotic metabolizing enzymes were compared. Parenteral administration of
Metanil yellow
and Orange II to rats at a dose of 80 mg/kg body weight for 3 days caused a significant induction of ethoxyresorufin-O-deethylase (40-190%), aniline hydroxylase (27-92%), aryl hydrocarbon hydroxylase (50-62%) and aminopyrine N-demethylase (42-49%) activities.
Metanil yellow
and Orange II brought about a substantial increase in cytosolic
quinone reductase
(34-82%) and glutathione S-transferase (23-43%) activities and significant depletion of glutathione levels with a concomitant increase in lipid peroxide formation. A blend (1:1) of
Metanil yellow
and Orange II showed a synergistic or additive effect on these hepatic parameters, suggesting that the addition of these two prohibited dyes together in foodstuffs may give rise to more toxic effects than are produced by each dye individually.
...
PMID:Effect of metanil yellow, orange II and their blend on hepatic xenobiotic metabolizing enzymes in rats. 804 63
Metanil yellow
, a non-permitted colour for food commodities, is used in the leather, paper and textile industries. In this paper the effect of oral and parenteral administration of
Metanil yellow
on hepatic and intestinal biochemical parameters was investigated. Oral administration of
Metanil yellow
(430 mg kg-1 body wt.) for 7 days caused significant depletion of hepatic and intestinal glutathione levels (33-52%) with a concomitant increase in lipid peroxidation (49-121%).
Metanil yellow
treatment for 7 days also led to a significant increase in cytochrome P-450 (P-450)-dependent aryl hydrocarbon hydroxylase (AHH) activity (99-223%) in the liver and intestine. Cytosolic glutathione-S-transferase (GST) (32-136%) and
quinone reductase
(QR) (20-92%) activities were also found to be substantially induced in hepatic and intestinal tissues following oral treatment of
Metanil yellow
. It is interesting to note that oral treatment of
Metanil yellow
showed a greater response in cytosolic enzymes of hepatic tissue as compared to intestine. Single parenteral administration of
Metanil yellow
(80 mg kg-1 body wt.) caused significant induction of P-450 and its dependent monooxygenases. Even after 5 days of single parenteral administration of
Metanil yellow
, hepatic AHH activity showed an elevation of 48% while other monooxygenases were marginally increased. Cytosolic GST and QR showed respective peak inductions of 92% and 60% after 2 and 3 days of parenteral administration of
Metanil yellow
, which levels off after the 5th day. It can be concluded that
Metanil yellow
acts as an inducer of a specific form of microsomal P-450 and cytosolic GST and QR, which may involve a cytosolic Ah receptor.
...
PMID:Effect of oral and parenteral administration of metanil yellow on some hepatic and intestinal biochemical parameters. 904 33
Metanil yellow
, a non-permitted food colour, has been found in various foodstuffs. The induction potential of metanil yellow on hepatic microsomal cytochrome P-450 (P-450)-dependent monooxygenases and cytosolic detoxification enzymes, namely, glutathione S-transferase (GST) and
quinone reductase
(QR), was investigated. Oral administration of metanil yellow (430 mg/kg body weight) to four animals for seven days caused significant induction of hepatic P-450 (48%) and its dependent aryl hydrocarbon hydroxylase (100%) activity and cytosolic GST (136%) and QR (92%) activities. Parenteral administration of metanil yellow (80 mg/kg body weight) to another set of four animals for 3 days resulted in higher induction of ethoxyresorufin-O-deethylase (228%) as compared to other monooxygenases (64-92%), while GST and QR were also found to be induced (59-95%). Spectra of metanil yellow-induced microsomes showed an increase in P-450 with a shift of 2.2 nm in the soret region. The results suggest that metanil yellow acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes and thus may involve the cytosolic aryl hydrocarbon (Ah) receptor for this type of induction.
...
PMID:Metanil yellow: a bifunctional inducer of hepatic phase I and phase II xenobiotic-metabolizing enzymes. 935 Feb 29
