Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.2 (
NQO1
)
6,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on
CYP2C8, CYP2C19, CYP4F11, CYP4F2,
PROS
, and
GGCX, VKORC1, CYP2C18,
NQO1
. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including,
CYP1A1, CYP3A4, CYP3A5
, and
F8
, and a low proportion of novel-to-known variants on
CYP2E1, VKORC1
, and
SULT1A1/2
. Using a Bayesian approach, we identified variants influencing acenocumarol dosing on,
VKORC1 (2), SULT1A1 (1)
, and
CYP2D8P (1)
explaining 40-55% of dose variability. A collection of pharmacogenetic variation on 110 genes related to the PK/PD of coumarins is also presented. Our results offer an initial insight into the use of a targeted NGS approach in the pharmacogenomics of coumarins in Mexican Mestizos.
...
PMID:Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol. 2921 11
