Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.2 (
NQO1
)
6,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Butylated hydroxyanisole (BHA) and its analogs were evaluated for their relative activity to induce hepatic
DT-diaphorase
(EC 1.6.99.2) after dietary administration (at concentrations of 11.1 or 27.7 micromol/g diet for 3 days) to mice. Of the compounds tested, only BHA and 2-tert-amyl-
4-methoxyphenol
, 4-methoxyphenols with 2-tert-alkyl side chains, were active in inducing
DT-diaphorase
activity. None of the remaining six compounds showed any significant sign of inducing activity. No simple explanation for these rather strict structural requirements can be offered at the present time.
...
PMID:Induction of hepatic DT-diaphorase in mice by butylated hydroxyanisole analogs: a structure-activity study. 1276 Apr 86
