Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.5.2 (NQO1)
 6,196 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Gene frequencies of esterase D, glyoxalase I and uridine monophosphate kinase in Alaskan populations were determined. 2. Improved methods for demonstrating phenotypes of glyoxalase I and uridine monophosphate kinase are presented. 3. Rare variants of adenylate kinase (AK1) and diaphorase (DIA) were found. One of the AK1 variants is new. 4. Gene frequencies were notably diverse within major ethnic groups. This variability was consistent with a population structure composed of small groups that were relatively isolated from one another.
 ...
PMID:Polymorphism of red cell enzymes in Alaskan ethnic groups. 62 78

Twenty-seven blood enzymes and proteins, whose structures are presumably controlled by at least 33 genes, were assayed in Arctic and silver foxes by starch gel electrophoresis. Two types of protein and enzyme electrophoretic patterns were distinguished: one exhibiting a single enzyme, the other several isozymes. The two fox species were found to differ in seven of the 27 enzymes and proteins studied: glucose-6-phosphate dehydrogenase, adenylate kinase, erythrocyte carboxylesterase, diaphorase, prealbumin, transferrin, and albumin. No differences were established between the species for the other enzymes and proteins. The data are interpreted as evidence for the existance of a set of enzymes and proteins differentiating the Arctic from the silver fox.
 ...
PMID:Allelic expression in intergeneric fox hybrids (Alopex lagopus x Vulpes vulpes). I. Comparative electrophoretic studies on blood enzymes and proteins in arctic and silver foxes. 101 23

A comparative study of 27 enzymes and proteins in blue and silver foxes was carried out by means of starch gel electrophoresis. The structure of these enzymes and proteins is determined by about 33 genes. It is shown that a number of blood enzymes and proteins of these species is represented by a single electrophoretic form, while lactate dehydrogenase, carboanhydrase, arylesterase, carboxylesterase, diaphorase, hexokinase and tetrasolium oxidase have several forms. It is also found that these species differ in seven enzymes and proteins: diaphorase, G-6-PD, adenylate kinase, carboxylesterase, albumin, prealbumin, transferrins. Other enzymes and proteins are similar in their electrophoretic mobility. The data obtained afford the evidence that the two species (Vulpes vulpes and Alopex lagopus) differ in a set of enzymes and proteins.
 ...
PMID:[Homologous gene expression in intergeneric fox hybrids (Alopex lagopus x Vulpes vulpes). I. Comparative electrophoretic analysis of blood proteins and enzymes in Arctic and silver foxes]. 121 28

By means of starch electrophoresis, 52 proteins and enzymes of Microtus arvalis and M. subarvalis were studied to establish the extent of their similarity. Out of 52 markers studied, 7 proteins and enzymes had different electrophoretic mobility: glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase (PGD), diaphorase (DP), adenylate kinase (AK), lactate dehydrogenase B (LDHB), alpha-galactosidase (GAL) and hemoglobin (Hb), which make up to 13% of all the enzymes and proteins studied. The differences found between the two species studied by electrophoretic mobility of G6PD, AK, GAL and Hb, as well as the absence of intraspecific polymorphism for the above proteins permit to consider these proteins as species-specific markers, with the help of which M. arvalis and M. subarvalis can be distinguished. It should be emphasized that intraspecific polymorphism was found for PGD, LDHB and DP in M. arvalis, while in M. subarvalis these proteins were monomorphic and identical, in their electrophoretic mobility, to one of electrophoretic variants of M. arvalis. Therefore, only one of allelic variants of PGD, LDHB and DP is species-specific. Estimation of the extent of genetic similarity based on analysis of distribution of gene frequencies for polymorphic loci of M. arvalis and M. subarvalis by means of Nei's method gave the value of 0.312, the genetic distance being 1.164. The data obtained, together with the known cytogenetic data, point to a species rank of the species studied. Moreover, in spite of the morphological similarity between M. arvalis and M. subarvalis, the estimation of genetic similarity proved to be close to that for morphologically contrasting species.
 ...
PMID:[Evaluation of the degree of genetic divergence in the twin species of the common vole Microtus arvalis and Microtus subarvalis (Rodentia)]. 638 3

The electrophoretic mobilities of 52 enzymes and proteins were used as measures of the genetic similarity between the sibling species Microtus arvalis and M. subarvalis. The two vole species differed in the electrophoretic mobilities of seven (glucose-6-phosphate dehydrogenase, adenylate kinase, diaphorase, lactate dehydrogenase-A, alpha-galactosidase, 6-phosphogluconate dehydrogenase, and hemoglobin) of these markers. This allowed us to accept the seven markers assayed as species-specific markers. Based on the frequency distribution of the genes at the polymorphic loci of M. arvalis and M. subarvalis, the degree of their genetic similarity was estimated as 0.312 and the genetic distance as 1.164 by Nei's formula. The estimates for genetic similarity were close to those obtained for species recognized as distinct.
 ...
PMID:An estimation of the degree of the genetic divergence of sibling species Microtus arvalis and Microtus subarvalis (Rodentia) based on electrophoretic analysis. 639 94