Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.6.5.2 (NQO1)
 6,196 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Potential masculinization, detoxification, and oxidative stress responses were assessed in domesticated female guppies (Poecilia reticulata) exposed for 42 days to diluted effluent from a modern Swedish kraft pulp mill or a model androgen. Methyltestosterone induced male-like coloration and transformation of the anal fin into a gonopodium-like structure. The effluent did not induce any apparent changes of the anal fin morphology; however, the exposed guppies became more colored than control fish, which could be an androgenic response. A better understanding of the physiological mechanisms involved in these responses would be required for a full evaluation. Both primary effluent and effluent which had undergone activated sludge treatment caused a moderate but significant induction of hepatic ethoxyresorufin-O-deethylase (EROD) activity. However, the general toxicity of both effluents was low, as mortality was negligible even at 25% dilutions. There was a continuous production of offspring in all groups (47-62% female fry), except by methyltestosterone-treated females, which did not reproduce. There were no indications that either effluent caused oxidative stress since hepatic glutathione reductase, glutathione S-transferase and DT-diaphorase activities remained unchanged compared with controls.
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PMID:Studies of masculinization, detoxification, and oxidative stress responses in guppies (Poecilia reticulata) exposed to effluent from a pulp mill. 1205 3