Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.5.2 (
NQO1
)
6,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Women are increasingly using botanical dietary supplements (BDS) to reduce menopausal
hot flashes
. Although licorice (
Glycyrrhiza
sp.) is one of the frequently used ingredients in BDS, the exact plant species is often not identified. We previously showed that in breast epithelial cells (MCF-10A),
Glycyrrhiza glabra
(GG) and
G. inflata
(GI), and their compounds differentially modulated P450 1A1 and P450 1B1 gene expression, which are responsible for estrogen detoxification and genotoxicity, respectively. GG and isoliquiritigenin (LigC) increased
CYP1A1
, whereas GI and its marker compound, licochalcone A (LicA), decreased
CYP1A1
and
CYP1B1
The objective of this study was to determine the distribution of the bioactive licorice compounds, the metabolism of LicA, and whether GG, GI, and/or pure LicA modulate NAD(P)H quinone oxidoreductase (
NQO1
) in an ACI rat model. In addition, the effect of licorice extracts and compounds on biomarkers of estrogen chemoprevention (
CYP1A1
) as well as carcinogenesis (
CYP1B1
) was studied. LicA was extensively glucuronidated and formed GSH adducts; however, free LicA as well as LigC were bioavailable in target tissues after oral intake of licorice extracts. GG, GI, and LicA caused induction of
NQO1
activity in the liver. In mammary tissue, GI increased
CYP1A1
and decreased
CYP1B1
, whereas GG only increased
CYP1A1
LigC may have contributed to the upregulation of
CYP1A1
after GG and GI administration. In contrast, LicA was responsible for GI-mediated downregulation of
CYP1B1
These studies highlight the polypharmacologic nature of botanicals and the importance of standardization of licorice BDS to specific
Glycyrrhiza
species and to multiple constituents.
...
PMID:Evidence for Chemopreventive and Resilience Activity of Licorice:
Glycyrrhiza Glabra
and G.
Inflata
Extracts Modulate Estrogen Metabolism in ACI Rats. 3028 22
