Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.3.1 (NADPH oxidase)
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Human Gene/Protein
THOX2 11.5
LNOX2 11.5
airway lactoperoxidase 11.5
HPX-2 11.5
p40phox 11.1
dual oxidase 11.1
NL7 11.0
THOX1 11.0
p67phox 11.0
p47phox 10.9
p22phox 10.8
p47 10.7
Dual oxidase 10.7
NOXO1 10.7
p47-phox 10.7
NOXA1 10.7
mitogenic oxidase 10.7
p67 10.6
p67-phox 10.5
beta-1,4-GalT IV 10.5
suppressor of actin 1 10.5
peroxidasin homolog-like 10.5
beta4Gal-T6 10.5
Engulfment and cell motility protein 1 10.5
C17orf62 10.5
MAP kinase phosphatase 4 10.5
NOX5 protein 10.5
Endothelial nitric oxidase synthase 10.5
NOX1 10.4
NOX3 10.4
CYBA 10.4
NCF4 10.3
NOX5 10.3
NOX2 10.3
DUOXA1 10.1
P22PHOX 10.1
DUOX1 10.1
CYBB 10.0
NCF2 9.9
CIP-1-associated regulator of cyclin B 9.9
PAFAH2 9.9
DUOX2 9.8
NOX4 9.8
NADPH oxidase 2 9.8
Ras-related C3 botulinum toxin substrate 2 9.5
-14 gene 9.5
SCN1 9.5
NCF1B 9.5
SH3B 9.5
hPLD2 9.5
HFTC 9.5
BDGI 9.5
DPI 9.4
p22 9.4
NADPH oxidase 1 9.3
DUOXA2 9.3
NADPH oxidase organizer 1 9.3
EEIG1 9.1
endothelial nitric oxidase synthase 9.1
hRFI 9.1
NCF1C 9.1
NADPH oxidase 5 9.1
PLB 8.9
ClC4 8.9
TNF receptor-associated factor 4 8.9
PKHDL1 8.9
TRAF3 interacting protein 2 8.9
macrophage expressed gene 1 8.9
HEP27 8.9
MOX1 8.9
ERp27 8.7
Grancalcin 8.7
PGAM-B 8.7
SK 2 8.7
SRPK3 8.7
ACIN1 8.7
Ste20-like protein kinase 8.7
transcription factor NRF 8.5
EFP1 8.5
Paraoxonase 2 8.5
more...
Disease
Chronic clonorchiasis 11.5
HFTC 9.5
inborn immunodeficiency 9.5
SCN1 9.5
Ehrlichia chaffeensis infection 9.1
chronic granulomatous disease 9.1
CGD 9.1
XLG2 9.0
congenital hyperbilirubinemia 8.8
Carotid artery thrombosis 8.7
Suppurative lymphadenitis 8.7
Chronic disseminated candidiasis 8.7
Intrauterine malnutrition 8.3
LFA-1 deficiency 8.1
Burkholderia cepacia infection 7.7
Chronic iron overload 7.6
phagocytic dysfunction 7.5
GTP cyclohydrolase I deficiency 7.5
bacterial colitis 7.0
Heartworm disease 7.0
Leukostasis 6.6
Gram-positive bacterial infection 6.6
TD2 6.5
Glycogen storage disease type Ib 6.4
kidney hypertrophy 6.4
HHT2 6.3
Carotid body 6.2
Carotid body 6.2
Carotid body 6.2
Endothelial dysfunction 6.1
WTS 6.1
CND 6.1
Autonomic imbalance 6.1
Persistent pulmonary hypertension 6.1
neurogenic hypertension 6.0
Pulmonary eosinophilia 6.0
CG3 6.0
Listeria meningitis 5.8
FBD 5.7
human granulocytic ehrlichiosis 5.6
ADA-SCID 5.6
Calcium deficiency 5.6
autoimmune vasculitis 5.6
Oral infection 5.5
AO2 5.5
Left ventricular diastolic dysfunction 5.5
diabetic cardiomyopathy 5.5
Neovascular age-related macular degeneration 5.4
Renal interstitial fibrosis 5.4
periodontosis 5.4
Chronic mucocutaneous candidiasis 5.3
Staphylococcus aureus pneumonia 5.3
silicotuberculosis 5.3
Renovascular hypertension 5.3
Influenza A virus infection 5.2
Cerebral hypoperfusion 5.2
Renal fibrosis 5.1
Estrogen deficiency 5.1
Diffuse panbronchiolitis 5.1
diabetic nephropathy 5.1
Klebsiella pneumoniae infection 5.1
GFD 5.1
Diabetic peripheral neuropathy 5.0
Heymann nephritis 5.0
Aspergillus fumigatus infection 5.0
Male hypogonadism 5.0
hyperhomocysteinemia 5.0
hyperoxaluria 5.0
NAME 4.9
hypertensive cardiomyopathy 4.9
Posterior capsule opacification 4.9
Viral myocarditis 4.9
Microangiopathy 4.8
alcoholic neuropathy 4.8
Lederer 4.8
G6PD deficiency 4.8
ileocolitis 4.8
McLeod syndrome 4.8
Chronic heart failure 4.7
ATM 4.7
more...
Symptom
Macula 6.6
impaired motor coordination 4.9
hyperoxia 4.1
scaly skin 4.0
skin damage 3.9
Noise-induced hearing loss 3.8
hyperesthesia 2.4
POA 2.4
Anoxia 2.4
adenitis 2.3
limb pain 2.1
HSA 1.9
muscle cramps 1.6
DNA marker 1.6
orofacial pain 1.6
microbial colonization 1.4
starvation 1.2
exhaustion 1.0
Neuropathic pain 1.0
respiratory distress 0.9
functional recovery 0.7
collapse 0.7
cachexia 0.6
chills 0.4
rhinorrhea 0.3
acute stress 0.3
bradykinesia 0.3
acidity 0.2
tachypnea 0.2
polyuria -0.1
cancer pain -0.1
colic -0.2
splenomegaly -0.2
weakness -0.3
angina -0.3
anesthesia -0.3
memory loss -0.4
overweight -0.4
hypercapnia -0.5
pelvic pain -0.5
diarrhea -0.5
hypothermia -0.6
hepatosplenomegaly -0.6
seizures -0.7
numbness -0.9
shortness of breath -0.9
thinning -1.0
pain -1.1
sleepiness -1.2
spasm -1.4
cough -1.5
chest pain -1.6
tremor -1.7
analgesia -1.7
low back pain -1.8
constipation -1.9
fatigue -1.9
insomnia -1.9
erythema -2.2
dyspnea -2.3
abdominal pain -2.5
headache -2.7
nausea -3.1
vomiting -3.5
Drug
Alagebrium chloride 10.5
Urocalun 10.5
Fenazox 9.9
CYSTEINE 8.3
Bv2 8.0
Tobramycin sulfate 7.7
Rilonacept 7.5
Idoxifene 7.3
Gentian violet 7.0
ROS 6.7
Epinastine 6.7
Sodium phenylbutyrate 6.7
Angiotensin II 6.6
Sulfaphenazole 6.5
Nebivolol 6.4
Ilomastat 6.2
FML 6.2
Prolastin 6.1
Olmesartan 6.1
Cilomilast 6.1
FAD 6.0
Venofer 5.9
BH4 5.8
Photofrin 5.8
Lantus 5.8
Crotonaldehyde 5.8
Cerezyme 5.7
Tenidap 5.7
Azelnidipine 5.7
NBT 5.6
Chloramine T 5.6
Alarin 5.6
Perhexiline 5.6
Digibind 5.5
Fenoldopam 5.5
Desferal 5.5
Rosuvastatin calcium 5.5
Aliskiren 5.4
Desferal 5.4
Omapatrilat 5.3
Rebamipide 5.2
Peppermint 5.2
NADH 5.2
Gramicidin D 5.2
Hakka 5.2
Gold sodium thiomalate 5.1
Lipitor 5.1
Fusicoccin 5.1
Aminoguanidine 5.1
Olmesartan medoxomil 5.0
Epigallocatechin 5.0
Malonaldehyde 4.8
Cerezyme 4.8
Heme 4.8
Lipitor 4.7
Lipitor 4.7
Nitric Oxide 4.6
Rosuvastatin 4.6
Gemifloxacin 4.6
Sodium citrate 4.6
Sodium citrate 4.6
Red ginseng 4.6
Valsartan 4.6
Pirfenidone 4.6
Indomethacin 4.4
Cilostazol 4.4
Bezafibrate 4.3
Febuxostat 4.3
Ibandronate 4.2
Enalaprilat 4.2
Corn oil 4.2
Zileuton 4.2
Enalaprilat 4.2
Emodin 4.2
Cibacron Blue 4.1
Pravastatin 4.1
GVG 4.1
Ergosterol 4.1
Podophyllum 4.1
Flavin 4.1
more...
Enzyme
NADPH oxidase 11.5
4-HPA 1-hydroxylase 11.5
NADPH oxidase 11.4
lysine N6-hydroxylase 9.5
glycolaldehyde dehydrogenase 9.1
phosphoglucokinase 9.1
fatty acid methyltransferase 9.1
NADPH peroxidase 8.9
4-hydroxyacetophenone monooxygenase 8.5
4-aminobenzoate hydroxylase 8.5
EC 5.1.3.5 8.3
coenzyme A disulfide reductase 7.8
rosmarinic acid synthase 7.7
D-cysteine desulfhydrase 7.5
PqqC 7.3
ent-kaurenoic acid oxidase 7.3
nicotinic acid hydroxylase 7.2
xanthine oxidase 7.2
propionate kinase 7.1
desulfhydrase 6.8
NADH peroxidase 6.8
LTB4 omega-hydroxylase 6.8
phenylacetone monooxygenase 6.8
AAO3 6.7
polyamine oxidase 6.6
SsuE 6.4
AO1 6.3
ent-copalyl diphosphate synthase 6.3
putrescine oxidase 6.3
SsuD 6.3
cinnamoyl-CoA reductase 6.2
p-hydroxybenzoate hydroxylase 6.2
oxalate oxidase 6.2
myo-inositol oxygenase 6.2
NADPH:quinone oxidoreductase 6.1
ascorbate peroxidase 6.1
p-hydroxybenzoate hydroxylase 6.1
DHOdehase 6.1
ent-kaurene oxidase 6.0
staphopain 6.0
glycolate oxidase 6.0
xanthine dehydrogenase 5.9
phospholipase D 5.9
bidirectional hydrogenase 5.9
aureolysin 5.9
NO synthase 5.9
disulfide reductase 5.9
DCF 5.8
12-lipoxygenase 5.8
copalyl diphosphate synthase 5.8
superoxide dismutase 5.8
PdxH 5.8
ceramide kinase 5.7
NSY 5.6
peptidylarginine deiminase 5.6
flavin reductase 5.5
dimethylarginine dimethylaminohydrolase 5.5
aggrecanase-1 5.5
NOS 5.5
ent-kaurene synthase 5.4
riboflavin kinase 5.4
protein kinase C 5.4
glutathione-insulin transhydrogenase 5.3
GTP cyclohydrolase I 5.3
catalase 5.3
thioredoxin reductase 5.2
peroxiredoxin 5.2
pyruvate:ferredoxin oxidoreductase 5.2
inositol 3-kinase 5.2
proline dehydrogenase 5.2
protein L-isoaspartyl methyltransferase 5.2
ABA 8'-hydroxylase 5.2
heme oxygenase 5.2
protein disulfide-isomerase 5.2
15-lipoxygenase 5.1
GPI-specific phospholipase C 5.1
neutral sphingomyelinase 5.1
adrenodoxin reductase 5.1
6-phosphogluconate dehydrogenase 5.1
6-phosphogluconate dehydrogenase 5.0
more...
Compound
N,N-dimethylselenourea 11.5
Apocynin 10.9
Jacareubin 10.5
Proanthocyanidin A2 9.9
Sequoyitol 9.9
C10H12O3 9.9
DPI 9.5
CoQ4 9.1
AcPyAD 8.9
biphenylene 8.8
biphenylene 8.7
beta-Amyrin 8.7
2-aminooctanoic acid 8.7
2-benzylidene-1-indanone 8.7
Diphenyliodonium chloride 8.7
Mepenzolate 8.7
Farrerol 8.5
benzenesulfonyl fluoride 8.5
Neoprontosil 8.5
undecanedioic acid 8.5
Tetrachlorobisphenol A 8.5
1,2,4-trimethylcyclohexane 8.5
Tetrachlorobisphenol A 8.5
1,2,4-trimethylcyclohexane 8.5
2-aminooctanoic acid 8.3
Dunnione 8.3
Tempol 8.3
Aspidin 8.1
ethanimidamide 8.1
Showdomycin 8.0
Daphnoretin 7.9
1,4-phthalazinedione 7.8
taurolithocholate 3-sulfate 7.8
Histamine dihydrochloride 7.8
Indicaxanthin 7.8
Cetiedil 7.8
Sepiapterin 7.7
8-Isoprostane 7.7
2-aminooctanoic acid 7.6
Glutaric acid 7.4
Guanidinosuccinic acid 7.4
Norathyriol 7.4
8-azaspiro[4.5]decane 7.4
superoxide radical 7.3
9-octadecenyl 7.3
Notoginsenoside R1 7.3
9-octadecenyl 7.3
Tiron 7.2
Eupafolin 7.2
butylcyclohexane 7.2
Decursinol 7.1
NADPH 7.1
NADPH 7.1
3,3-dimethyl-1-butanol 7.1
DPPD 7.1
Cypridina luciferin 7.1
Ang II 7.1
Linalyl acetate 7.0
Hydroxyeicosatetraenoic acid 7.0
Taurolithocholate 6.9
Rottlerin 6.9
Aminocyclopropane 6.8
Phenylarsine oxide 6.8
Oxypurinol 6.8
Rottlerin 6.8
C6H5NO2 6.8
Glyceollin 6.8
Glyceollin 6.8
3,4-D 6.8
Rottlerin 6.8
Octyl gallate 6.7
Cucurbitacin I 6.7
Aminoimidazole 6.7
nicotinamide 6.7
Sodium hydrosulfide 6.6
Acetylshikonin 6.6
9-AC 6.6
FMLP 6.5
Chloranil 6.5
fMet 6.5
more...