Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.6.3.1 (NADPH oxidase)
11,281 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
NADPH 1222
superoxide dismutase 968
p47 929
Mol 810
catalase 733
Sep 725
ROS 696
p47phox 611
angiotensin II 594
nitric oxide synthase 575
p22phox 545
NOX2 511
p38 463
p22 461
Ang II 436
xanthine oxidase 432
cytokine 418
p67 417
MAPK 378
NOX4 360
ERK1 356
inducible nitric oxide synthase 356
TNF 338
insulin 331
lipopolysaccharide 315
myeloperoxidase 304
p67phox 291
NADH 288
tumor necrosis factor 287
caspase-3 272
NAD 251
SOD 249
renin 249
DPI 248
ATP 246
collagen 237
peroxidase 234
GSH 231
membrane-bound 230
PKC 216
ERK 208
IL-6 204
JNK 200
glutathione peroxidase 200
NOX1 198
GTP 191
cytochrome c 191
endothelial nitric oxide synthase 190
eNOS 182
p47-phox 168
NADPH oxidase 2 162
cytochrome b 157
endoplasmic reticulum 156
X-linked 155
p67-phox 155
p40 150
LPS 148
dual oxidase 147
Rho 145
mitogen-activated protein 137
heme oxygenase-1 136
p65 136
GTPase 132
PI3K 130
TNF-alpha 129
reductase 129
extracellular signal-regulated kinase 126
tyrosine kinase 124
FAD 123
TLR4 121
cyclooxygenase 120
cytochrome 118
AT1 114
ANG 111
small GTPase 111
flavoprotein 106
Bcl-2 106
p40phox 104
ATPase 101
p38 mitogen-activated protein kinase 100
more...
Disease
hypertension 846
diabetes 606
atherosclerosis 533
chronic granulomatous disease 508
cancer 401
ischemia 301
tumor 238
GSH 231
cardiovascular disease 226
stroke 200
heart failure 197
hyperglycemia 169
Alzheimer's disease 160
obesity 159
NAME 145
diabetic nephropathy 131
type 2 diabetes 126
Parkinson's disease 120
immunodeficiency 119
ATM 117
sepsis 102
renal disease 101
vascular disease 99
sepsis 96
metabolic syndrome 92
myocardial infarction 90
proteinuria 88
plaque 80
carcinogenesis 73
cerebral ischemia 72
pertussis 69
infectious diseases 62
rheumatoid arthritis 61
hypercholesterolemia 59
pulmonary hypertension 59
Mycobacterium 58
leukemia 58
asthma 56
SDS 54
glomerulosclerosis 54
hepatocellular carcinoma 54
arthritis 53
inflammatory bowel disease 50
HIV 48
myocardial ischemia 47
cognitive impairment 47
Endothelial dysfunction 46
coronary artery disease 45
Blocking 45
tumor progression 43
Infection 42
ventricular hypertrophy 42
CGD 42
tuberculosis 41
pneumonia 41
breast cancer 41
tumorigenesis 40
depression 38
dementia 38
colitis 38
tumor growth 37
bacterial infection 37
hyperhomocysteinemia 36
Epstein 36
adenocarcinoma 36
neuroblastoma 36
type 1 diabetes 35
diabetic retinopathy 34
melanoma 34
prostate cancer 34
liver fibrosis 34
renal failure 33
cold 33
hyperlipidemia 32
cystic fibrosis 32
multiple sclerosis 32
carcinoma 30
fatty liver 30
cardiomyopathy 30
chronic obstructive pulmonary disease 29
more...
Symptom
pain 44
hyperoxia 32
anesthesia 31
starvation 20
collapse 17
seizures 17
diarrhea 14
respiratory distress 13
weakness 11
exhaustion 10
functional recovery 8
skin damage 8
overweight 7
angina 6
acidity 6
fatigue 5
HSA 4
hypothermia 4
Macula 4
splenomegaly 3
cough 3
cachexia 3
headache 3
analgesia 3
chills 2
chest pain 2
abdominal pain 2
impaired motor coordination 2
thinning 2
tremor 2
acute stress 2
sleepiness 2
dyspnea 2
hypercapnia 2
muscle cramps 1
Anoxia 1
orofacial pain 1
hyperesthesia 1
insomnia 1
Neuropathic pain 1
colic 1
nausea 1
numbness 1
scaly skin 1
constipation 1
adenitis 1
DNA marker 1
POA 1
shortness of breath 1
erythema 1
hepatosplenomegaly 1
low back pain 1
limb pain 1
memory loss 1
pelvic pain 1
polyuria 1
vomiting 1
cancer pain 1
rhinorrhea 1
microbial colonization 1
Noise-induced hearing loss 1
spasm 1
tachypnea 1
bradykinesia 1
Drug
ROS 696
NADH 286
Angiotensin II 180
FAD 123
ascorbate 110
Cardiovasc 98
IFN-gamma 58
vitamin E 53
Indomethacin 48
MAP 42
CSF 40
lysine 39
Heme 30
BH4 30
nitroglycerin 28
Ethanol 25
Nitric Oxide 23
NBT 23
Gel 18
Photofrin 18
Dermatol 17
ETA 14
ICI 13
DNase I 12
Glutathione 12
Leaf 11
Histamine 9
IL-2 9
Nebivolol 8
ENT 8
Bifidobacterium 8
Capsicum 7
niacin 7
CAM 7
Simvastatin 7
caffeine 6
Asthma 6
Albumin 6
Glucagon 6
Arsenic trioxide 6
Forskolin 6
p75 5
Olmesartan 5
ACT 5
Epigallocatechin 5
Aminoguanidine 5
Monit 5
Nephron 5
TAT 5
CoCl2 5
Fluorescein 5
Captopril 5
Pravastatin 5
CoCl2 5
Fructose 5
Propofol 5
ALA 4
Aliskiren 4
Desferal 4
Vitamin E 4
TAK 4
Valsartan 4
Adenosine triphosphate 4
Rosuvastatin 4
Desferal 4
Spectrum 4
Rosiglitazone 4
G-CSF 4
Asn 4
ZnCl2 4
ZnCl2 4
Prednisolone 3
TiO2 3
Cibacron Blue 3
Emodin 3
Tocopherol 3
CCL 3
IFN-beta 3
Fenoldopam 3
TMS 3
more...
Enzyme
NADPH oxidase 11281
NADPH oxidase 10176
superoxide dismutase 1153
mitogen-activated protein kinase 1072
catalase 749
protein kinase C 746
peroxidase 546
xanthine oxidase 441
NO synthase 326
protein kinase 322
ERK 288
renin 249
glutathione peroxidase 209
caspase-3 206
MEK 123
phospholipase A2 118
NOS 116
ATPase 113
phospholipase C 107
glutathione reductase 96
complex I 91
phosphatidylinositol 3-kinase 91
phospholipase D 81
focal adhesion kinase 78
AMP-activated protein kinase 71
ascorbate peroxidase 69
ACE 67
lactate dehydrogenase 65
glucose-6-phosphate dehydrogenase 62
diaphorase 61
luciferase 59
thrombin 54
heme oxygenase 53
caspase-1 53
lipoxygenase 51
PARP 51
CPR 51
tyrosine hydroxylase 42
calcineurin 41
elastase 41
phosphoinositide 3-kinase 40
DCF 40
MAP 40
AMPK 37
phosphodiesterase 37
neutrophil elastase 37
peroxiredoxin 35
thioredoxin reductase 33
IKK 32
glutathione S-transferase 32
reverse transcriptase 32
proteasome 32
NQO1 31
AMPK 31
guanylate cyclase 29
NADPH-diaphorase 28
thyroid peroxidase 28
caspase-9 28
xanthine dehydrogenase 27
adenylate cyclase 26
alkaline phosphatase 26
alanine aminotransferase 25
trypsin 25
arginase 24
lysozyme 24
glucose oxidase 22
collagenase 22
aspartate aminotransferase 21
caspase-8 19
succinate dehydrogenase 18
6-phosphogluconate dehydrogenase 17
CaMKII 17
12-lipoxygenase 17
6-phosphogluconate dehydrogenase 17
RNA polymerase 17
diaphorase 17
nitrate reductase 16
nitrate reductase 16
nitrate reductase 16
demethylase 16
more...
Compound
oxygen 5604
NADPH 1224
NADPH 1222
nitric oxide 1013
hydrogen 891
Dec 792
calcium 782
phosphate 674
H2O2 642
acetate 641
glucose 627
nicotinamide 583
DNA 583
sodium 366
superoxide radical 357
Clin 352
cysteine 342
TNF 338
water 335
Ang II 323
tyrosine 302
NADH 287
Phe 283
arginine 270
NAD 259
N-acetylcysteine 257
NAD 251
DPI 248
ATP 248
nitrogen 247
GSH 241
GSH 241
salt 230
PMA 218
PMA 215
Angiotensin II 209
Apocynin 203
GTP 191
iron 157
NADP 154
leucine 143
diacetate 132
serine 129
ethanol 129
sulfate 125
FAD 124
cAMP 122
aldosterone 119
methionine 114
glutamate 103
potassium 100
cGMP 96
Cardiol 94
zinc 93
THP 91
THP 89
nitrate 89
PEG 89
galactose 77
Panam 75
creatinine 74
AMP 71
GDP 71
cyanide 69
Tempol 69
ADP 68
threonine 68
iodine 66
ADP 63
ADP 63
CO2 62
copper 61
SDS 60
manganese 59
Insulin 59
GSSG 59
ACh 58
8-OHdG 58
salicylic acid 57
lysine 56
more...