Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.3.1 (
NADPH oxidase
)
11,281
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Histone H2B monoubiquitination (H2Bub1) plays critical roles in regulating growth and development as well as stress responses in Arabidopsis (
Arabidopsis thaliana
). In this study, we used wild-type and HUB1 and HUB2 loss-of-function Arabidopsis plants to elucidate the mechanisms involved in the regulation of the plant's defense responses to
Verticillium dahliae
toxins (Vd-toxins). We demonstrated that HUB-mediated H2Bub1 regulates the expression of the
NADPH oxidase
RbohD
by enhancing the enrichment of histone H3 trimethylated on Lys-4 in response to Vd-toxins.
RbohD
-dependent hydrogen peroxide (H
2
O
2
) signaling is a critical modulator in the defense response against Vd-toxins. Moreover, H2Bub1 also affects posttranscriptional mitogen-activated protein kinase (or MPK) signaling. H2Bub1 was required for the activation of MPK3 and MPK6. MPK3 and MPK6 are involved in regulating
RbohD
-mediated H
2
O
2
production. MPK3 and MPK6 are associated with protein tyrosine phosphatases (PTPs), such as Tyr-specific phosphatase1 and mitogen-activated protein kinases phosphatase1, which negatively regulated H
2
O
2
production. In addition, H2Bub1 is involved in regulating the expression of
WRKY33
WRKY33 directly binds to
RbohD
promoter and functions as a transcription factor to regulate the expression of
RbohD
Collectively, our results indicate that H2Bub1 regulates the
NADPH oxidase
RbohD
-dependent H
2
O
2
production and that the
PTP
-MPK3/6-WRKY pathway plays an important role in the regulation of
RbohD
-dependent H
2
O
2
signaling in defense responses to Vd-toxins in Arabidopsis.
...
PMID:H2Bub1 Regulates
RbohD
-Dependent Hydrogen Peroxide Signal Pathway in the Defense Responses to
Verticillium dahliae
Toxins. 3166
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