Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.6.3.1 (
NADPH oxidase
)
11,281
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
NADPH oxidase
is an important source of superoxide in the central nervous system. Although
NADPH oxidase
is localized near the postsynaptic site in neurons, little is known about the pathophysiological role of
NADPH oxidase
in synapses after cerebral ischemia and reperfusion. In the present study, we sought to determine the role of
NADPH oxidase
in oxidative damage to postsynaptic density (PSD) proteins, which were isolated from rats subjected to transient focal cerebral ischemia and reperfusion. The amounts of carbonylated PSD proteins were increased after transient focal cerebral ischemia and reperfusion. This change was accompanied by an increase in the level of
NADPH oxidase
subunits in the PSD. The administration of apocynin, an
NADPH oxidase
inhibitor, attenuated both the protein carbonylation in the PSD and cerebral infarct volume. We further demonstrated that the decreases seen in the amounts of PSD-associated proteins, such as neuroligin, N-cadherin, and
SAP102
, in the PSD were prevented by treatment with apocynin. These results suggest that pronounced activation of
NADPH oxidase
in the PSD after cerebral ischemia and reperfusion may be related to the focal oxidative damage to synaptic functions and subsequent development of ischemia and reperfusion-induced cerebral injury.
...
PMID:NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion. 2126 62
