Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.7.1 (methylenetetrahydrofolate reductase)
 2,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
methylenetetrahydrofolate reductase 2013
5,10-methylenetetrahydrofolate reductase 299
MTHFR 230
prothrombin 193
Mol 172
B12 164
factor V Leiden 162
Sep 151
methionine synthase 150
methionine synthase reductase 94
factor V 87
MTRR 83
thymidylate synthase 82
MTR 71
protein C 63
cystathionine beta-synthase 63
protein S 56
plasminogen activator inhibitor-1 53
reduced folate carrier 45
plasminogen activator inhibitor 40
methylenetetrahydrofolate dehydrogenase 33
antithrombin 33
fibrinogen 33
apolipoprotein E 27
methyltransferase 26
reductase 25
dihydrofolate reductase 24
antithrombin III 23
Methylenetetrahydrofolate reductase 23
CBS 23
insulin 21
Polymerase 20
C-reactive protein 18
UTR 17
serine hydroxymethyltransferase 17
She 17
dihydropyrimidine dehydrogenase 17
glutathione S-transferase 17
factor VIII 17
glycoprotein 16
cystathionine-beta-synthase 16
SAM 16
HDL 16
FAD 15
endothelial nitric oxide synthase 15
MTHFD1 15
MRI 14
NADPH 14
B-12 14
RFC 13
SLC19A1 13
GSTT1 13
hemoglobin 13
thrombin 12
apolipoprotein 12
ANOVA 12
RFC1 12
GSTM1 12
factor VII 11
angiotensinogen 11
5-methyltetrahydrofolate-homocysteine methyltransferase 11
catechol-O-methyltransferase 10
p53 10
CRP 10
Met 10
NADH 10
FOLR1 10
TYMS 10
Lp(a) 10
thymidylate synthetase 10
albumin 10
APOE 9
GSTP1 9
plasminogen 9
glycoprotein IIIa 8
eNOS 8
flavoprotein 8
cytokine 8
RFC) 8
transcobalamin II 8
more...
Disease
hyperhomocysteinemia 327
cancer 234
stroke 163
cardiovascular disease 125
vascular disease 92
atherosclerosis 92
coronary artery disease 85
hypertension 83
colorectal cancer 75
tumor 69
acute lymphoblastic leukemia 59
diabetes 58
folate deficiency 58
breast cancer 58
carcinogenesis 56
homocystinuria 54
schizophrenia 53
myocardial infarction 48
deep vein thrombosis 39
preeclampsia 38
Alzheimer's disease 35
Down syndrome 35
systemic lupus erythematosus 34
abortion 32
lymphoma 31
lupus 31
renal disease 30
lupus 30
obesity 27
childhood ALL 27
dementia 25
rheumatoid arthritis 25
migraine 24
gastric cancer 22
pulmonary embolism 22
leukemia 21
Thrombophilia 20
coronary heart disease 20
colon cancer 19
osteoporosis 19
cognitive impairment 18
vitamin B12 deficiency 17
male infertility 17
metabolic syndrome 17
cleft palate 16
infertility 16
lung cancer 16
type 2 diabetes 16
Parkinson's disease 15
carcinoma 15
malnutrition 14
acute myocardial infarction 14
adenoma 14
depression 14
sickle cell disease 14
epilepsy 14
anemia 13
diabetic nephropathy 13
heart disease 13
renal failure 13
developmental delay 12
bipolar disorder 12
essential hypertension 12
hepatocellular carcinoma 11
cerebral infarction 11
tumorigenesis 10
megaloblastic anemia 10
squamous cell carcinoma 10
arteriosclerosis 9
cirrhosis 9
psychosis 9
eclampsia 9
adenocarcinoma 9
autism 9
plaque 9
genetic disorder 8
transient ischemic attack 8
bladder cancer 8
polycystic ovary syndrome 8
retinopathy 8
more...
Symptom
headache 18
seizures 15
overweight 10
pain 8
hypotonia 5
fatigue 5
ataxia 5
vomiting 5
abdominal pain 5
weakness 5
tremor 4
angina 4
nausea 4
spasm 3
paraparesis 3
spasticity 3
dysarthria 3
dyspnea 2
chest pain 2
numbness 2
cough 2
metamorphopsia 1
hemoptysis 1
anesthesia 1
hand pain 1
hypothermia 1
limb pain 1
photophobia 1
pallor 1
hepatomegaly 1
cachexia 1
hypertonia 1
paresis 1
stigma 1
anorexia 1
neck pain 1
cyanosis 1
lethargy 1
diarrhea 1
insomnia 1
photopsia 1
dizziness 1
memory loss 1
inanition 1
Decreased activity 1
hemiplegia 1
Livedoid 1
Drug
THF 26
FAD 15
Vitamin B12 15
Cardiovasc 10
NADH 10
pyridoxal phosphate 9
CSF 6
lysine 5
Vitamin B 5
Fragment 4
Monit 4
vitamin E 3
Nephron 3
ascorbate 3
Cobalamin 3
Dermatol 2
CTX 2
Bevacizumab 2
Hakka 2
Nephron 2
Folic Acid 2
CTX 1
CTA 1
DDAVP 1
Gemfibrozil 1
MDS 1
Asn 1
CTX 1
Indomethacin 1
Pyridoxal 1
GVG 1
TEL 1
niacin 1
Arsenic trioxide 1
Lamisil 1
IL-2 1
Fructose 1
DDAVP 1
TAC 1
Fluorescein 1
Deoxyadenosine 1
Ethanol 1
ICI 1
AZT 1
Amiloride 1
Pemetrexed 1
ENT 1
Oxaliplatin 1
Portal 1
Paraffin 1
Fluorescein 1
PTH 1
ROS 1
Leucovorin 1
Troglitazone 1
Riboflavin 1
Lamisil 1
Leaf 1
Simvastatin 1
AZT 1
Enzyme
methylenetetrahydrofolate reductase 2116
methylenetetrahydrofolate reductase 2116
methionine synthase 152
methionine synthase 147
methionine synthase reductase 89
thymidylate synthase 83
APC 80
cystathionine beta-synthase 63
methylenetetrahydrofolate dehydrogenase 33
methylenetetrahydrofolate dehydrogenase 26
dihydrofolate reductase 25
ACE 22
serine hydroxymethyltransferase 19
glutathione S-transferase 18
homocysteine methyltransferase 18
dihydropyrimidine dehydrogenase 17
cyclohydrolase 16
dihydropyrimidine dehydrogenase 15
methionine adenosyltransferase 14
formyltetrahydrofolate synthetase 13
thrombin 12
NQO1 9
thiopurine methyltransferase 8
aldehyde dehydrogenase 8
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
ERK 7
tissue plasminogen activator 7
aldehyde dehydrogenase 7
aspartate aminotransferase 6
betaine-homocysteine methyltransferase 6
paraoxonase 5
cystathionine gamma-synthase 5
calcineurin 5
phosphatidylethanolamine N-methyltransferase 5
glutathione reductase 5
paraoxonase 5
renin 4
thymidine phosphorylase 4
folylpolyglutamate synthetase 4
endonuclease 4
superoxide dismutase 4
DNA methyltransferase 4
cystathionine gamma-lyase 4
lipase 4
ATPase 4
glycine N-methyltransferase 4
P-glycoprotein 3
peroxidase 3
diaphorase 3
alcohol dehydrogenase 3
cholesterol acyltransferase 3
alkaline phosphatase 3
CAD 3
UDP-glucuronosyltransferase 3
conjugase 3
10-formyltetrahydrofolate dehydrogenase 3
CAD 3
5,10-methenyltetrahydrofolate synthetase 3
carboxypeptidase G2 3
PTA 3
glucose-6-phosphate dehydrogenase 3
AGT 3
prostate-specific membrane antigen 3
focal adhesion kinase 3
CAD 3
methionyl-tRNA synthetase 3
furin 3
proprotein convertase 3
subtilisin 3
asparaginase 3
choline dehydrogenase 3
thromboplastin 3
lactate dehydrogenase 2
glutathione peroxidase 2
catalase 2
protein phosphatase 2A 2
lysyl oxidase 2
phospholipase A2 2
more...
Compound
homocysteine 780
DNA 337
methionine 241
Dec 164
Clin 160
PGA 127
Homocysteine 83
Homocysteine 83
adenosylmethionine 71
betaine 46
alanine 44
creatinine 37
valine 27
Cardiol 25
CBS 23
S-adenosylhomocysteine 22
water 21
glucose 21
cysteine 20
Methotrexate 20
serine 19
oxygen 18
FAD 16
NADPH 14
His 14
NADPH 14
nitric oxide 13
CH3-THF 12
calcium 12
Pac 12
acetate 11
sodium 11
phosphate 11
Methionine 10
NADH 10
glutamate 10
TMP 9
5,10-methenyltetrahydrofolate 9
Choline 8
nicotinamide 8
folinic acid 8
NAD 8
urea 8
arginine 8
5-FU 8
dUMP 8
5-formyltetrahydrofolate 7
lysine 7
NAD 7
hydrogen 7
vitamin D 7
formaldehyde 7
ethanol 7
formaldehyde 6
threonine 5
pyrimidine 5
CO2 5
NADP 5
sulfate 5
ATP 5
leucine 5
pyrimidine 5
nicotinic acid 5
Valproic acid 4
Hemoglobin 4
H2S 4
Gly 4
iron 4
uridine 4
aldosterone 4
tryptophan 4
tryptophan 4
Asp 4
dihydrofolate 4
tryptophan 4
tryptophan 4
isoleucine 3
THF 3
PDT 3
Cholesterol 3
more...