Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.7.1 (methylenetetrahydrofolate reductase)
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Human Gene/Protein
adrenergic, beta-3-, receptor 13.9
cholesteryl ester transfer protein, plasma 13.9
5,10-methylenetetrahydrofolate reductase 13.9
CDK5 regulatory subunit associated protein 1 13.9
methylenetetrahydrofolate reductase 13.9
intrinsic factor-vitamin B12 receptor 12.9
methionine synthase reductase 12.6
5-methyltetrahydrofolate-homocysteine methyltransferase 12.4
Leukocyte immunoglobulin-like receptor A3 12.3
alpha-1A-adrenergic receptor 12.3
serine hydroxymethyltransferase 1 12.2
glutathione S-transferase class theta 11.9
cytoplasmic serine hydroxymethyltransferase 11.7
methylenetetrahydrofolate dehydrogenase 11.3
FTHFD 11.3
Cytosolic serine hydroxymethyltransferase 11.3
methionine synthase 11.3
MTR 11.2
MTHFR 11.2
MTHFD1 11.1
more...
Disease
Dihydrofolate reductase deficiency 12.9
Factor II mutation 11.9
adult meningioma 11.9
glutamate formiminotransferase deficiency 11.6
methionine synthase deficiency 11.5
Mesenteric infarction 10.9
Placental infarction 10.7
hyperhomocysteinemia 10.6
CBS deficiency 10.2
homocystinemia 10.0
NFLD 10.0
Left main coronary artery disease 9.9
Factor V Leiden mutation 9.8
homocystinuria 9.7
Activated protein C resistance 9.6
Primary angle-closure glaucoma 9.3
Bipolar II disorder 9.1
cblF 9.1
folate deficiency 9.0
Thrombophilia 9.0
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Symptom
Livedoid 8.2
photopsia 6.8
hand pain 6.2
inanition 6.1
metamorphopsia 5.9
Decreased activity 4.8
limb pain 4.5
paraparesis 4.0
hypotonia 3.7
hypertonia 3.6
dysarthria 3.6
photophobia 3.3
spasticity 2.8
spasm 2.6
pallor 2.6
numbness 2.5
overweight 2.5
headache 2.3
ataxia 2.2
memory loss 2.1
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Drug
Folic Acid 8.9
Hakka 8.6
Lamisil 7.7
Lamisil 7.6
Vitamin B12 7.5
Cobalamin 7.4
Deoxyadenosine 6.9
GVG 6.5
Vitamin B 5.9
Pyridoxal 5.9
pyridoxal phosphate 5.7
THF 5.6
Gemfibrozil 5.5
FAD 5.4
Pemetrexed 5.2
Leucovorin 4.9
Troglitazone 4.8
Fragment 4.7
Riboflavin 4.3
TEL 4.3
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Enzyme
methylenetetrahydrofolate reductase 13.9
methylenetetrahydrofolate reductase 13.9
methionine synthase reductase 12.7
methylenetetrahydrofolate dehydrogenase 11.8
methylenetetrahydrofolate dehydrogenase 11.7
methionine synthase 11.4
methionine synthase 11.3
5,10-methenyltetrahydrofolate synthetase 10.9
homocysteine methyltransferase 10.7
formyltetrahydrofolate synthetase 10.4
cystathionine beta-synthase 9.9
glutamate formiminotransferase 9.9
10-formyltetrahydrofolate dehydrogenase 9.4
choline dehydrogenase 9.2
betaine-homocysteine methyltransferase 9.1
cyclohydrolase 9.1
AICAR transformylase 9.1
serine hydroxymethyltransferase 8.9
homoserine transacetylase 8.8
formylmethanofuran dehydrogenase 8.8
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Compound
Menoctone 11.9
homocysteine 10.0
Homocysteine 9.9
Homocysteine 9.9
CH3-THF 9.6
5,10-methenyltetrahydrofolate 9.5
PGA 8.7
Diamant 8.5
Thiouracil 8.3
Tetrahydrocurcumin 8.2
5,10-methylene-THF 7.9
5-formyltetrahydrofolate 7.9
Benazepril 7.8
dUMP 7.5
Cobalamin 7.4
10-formyltetrahydrofolate 7.2
betaine 7.2
Deoxyadenosine 7.0
adenosylmethionine 7.0
S-adenosylhomocysteine 6.9
more...