Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.7.1 (methylenetetrahydrofolate reductase)
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Human Gene/Protein
cholesteryl ester transfer protein, plasma 13.9
5,10-methylenetetrahydrofolate reductase 13.9
adrenergic, beta-3-, receptor 13.9
methylenetetrahydrofolate reductase 13.9
CDK5 regulatory subunit associated protein 1 13.9
intrinsic factor-vitamin B12 receptor 12.9
methionine synthase reductase 12.6
5-methyltetrahydrofolate-homocysteine methyltransferase 12.4
Leukocyte immunoglobulin-like receptor A3 12.3
alpha-1A-adrenergic receptor 12.3
serine hydroxymethyltransferase 1 12.2
glutathione S-transferase class theta 11.9
cytoplasmic serine hydroxymethyltransferase 11.7
methylenetetrahydrofolate dehydrogenase 11.3
FTHFD 11.3
Cytosolic serine hydroxymethyltransferase 11.3
methionine synthase 11.3
MTR 11.2
MTHFR 11.2
MTHFD1 11.1
solute carrier family 6 member 4 11.1
methylenetetrahydrofolate dehydrogenase 1 11.1
MTRR 11.0
solute carrier family 19 member 1 10.9
cystathionine-beta-synthase 10.9
MTHFS 10.8
LCMT1 10.7
CNTNAP4 10.7
reduced folate carrier 10.7
TCN2 10.7
AGTRAP 10.6
SLC19A1 10.5
cystathionine beta-synthase 10.5
factor V Leiden 10.4
Partitioning defective 3-like protein 10.4
SHMT1 10.3
formyltetrahydrofolate dehydrogenase 10.2
methionine adenosyltransferase II 10.2
RFC1 10.2
Methylenetetrahydrofolate reductase 10.0
formyltetrahydrofolate synthetase 10.0
N-acetyltransferase-1 10.0
Reduced Folate Carrier 9.8
APBB1 9.8
CENP-Q 9.8
BHMT2 9.8
ornithine decarboxylase 1 9.7
Reduced folate carrier 9.7
KCNIP4 9.7
betaine homocysteine methyltransferase 9.6
leucine carboxyl methyltransferase 9.6
FTCD 9.6
UBE4B 9.6
cytosolic serine hydroxymethyltransferase 9.6
TYMS 9.5
GJA4 9.4
glutathione S-transferase omega 1 9.4
PRICKLE2 9.4
betaine-homocysteine methyltransferase 9.3
FR-beta 9.3
factor V 9.3
cblD 9.2
glucose-6-phosphate 1-dehydrogenase 9.2
choline dehydrogenase 9.2
FOLR2 9.2
beta-fibrinogen 9.2
MAP7 9.1
serine hydroxymethyltransferase 9.1
BHMT 9.1
GP1BA 9.1
CD320 9.0
calmodulin 1 9.0
FOLR1 9.0
TNFRSF8 8.9
MMACHC 8.9
DACT2 8.9
coagulation factor V 8.9
hemoglobin beta chain 8.8
LSM2 8.8
MAGEA1 8.8
type I protein C 8.8
glycoprotein IIIa 8.8
transforming growth factor beta receptor II 8.7
SHMT 8.7
thymidylate synthase 8.7
MAT2B 8.7
phosphatidylethanolamine N-methyltransferase 8.6
hepatocyte nuclear factor 1 alpha 8.6
MAT2A 8.6
Glycine N-methyltransferase 8.6
fidgetin 8.6
dimethylglycine dehydrogenase 8.6
HOXB3 8.6
dopamine receptor D3 8.6
PTHR 8.5
PEMT 8.5
cblF 8.5
GCP2 8.5
RFC 8.5
damage-regulated autophagy modulator 8.5
FLT3 receptor tyrosine kinase 8.5
GTL2 8.4
ITGB3 8.4
B-12 8.3
histone-lysine N-methyltransferase 8.3
ERCC4 8.3
FilGAP 8.3
RASGRP1 8.3
ADRA1A 8.3
coagulation factor II 8.3
GPR8 8.3
carnitine palmitoyltransferase 1A 8.2
MAT1A 8.1
B12 8.1
NIPA1 8.1
thiopurine methyltransferase 8.1
glutathione-S-transferase M1 8.1
LSM1 8.1
S-adenosylhomocysteine hydrolase 8.0
CBFA2T3 8.0
sarcosine dehydrogenase 8.0
10-formyltetrahydrofolate dehydrogenase 8.0
GART 8.0
LIPC 8.0
CUBN 8.0
SHMT2 8.0
Serine hydroxymethyltransferase 7.9
GSTO1 7.9
DCP1 7.9
Myf-6 7.9
NaSi-1 7.9
Glycerol kinase 7.9
ADRB3 7.8
disrupted in schizophrenia 1 7.8
SULT1A2 7.8
PCK2 7.8
protein S 7.8
glutamate carboxypeptidase II 7.8
dihydropyrimidine dehydrogenase 7.7
Engrailed-2 7.7
ITGA2 7.7
endothelial lipase 7.7
COL18A1 7.7
HTR2C 7.7
inosine triphosphatase 7.7
transforming growth factor beta 3 7.7
NPPA 7.7
prothrombin 7.6
MOv18 7.6
von Willebrand factor-cleaving protease 7.6
Methionine adenosyltransferase 7.6
MEST 7.6
choline acetylase 7.6
folate-binding protein 7.6
PTPN6 7.6
MINT2 7.5
bleomycin hydrolase 7.5
folylpolyglutamate synthetase 7.5
NSCL 7.5
cblA 7.5
more...
Disease
Dihydrofolate reductase deficiency 12.9
Factor II mutation 11.9
adult meningioma 11.9
glutamate formiminotransferase deficiency 11.6
methionine synthase deficiency 11.5
Mesenteric infarction 10.9
Placental infarction 10.7
hyperhomocysteinemia 10.6
CBS deficiency 10.2
homocystinemia 10.0
NFLD 10.0
Left main coronary artery disease 9.9
Factor V Leiden mutation 9.8
homocystinuria 9.7
Activated protein C resistance 9.6
Primary angle-closure glaucoma 9.3
Bipolar II disorder 9.1
cblF 9.1
folate deficiency 9.0
Thrombophilia 9.0
Imerslund 9.0
vitamin B deficiency 8.4
cystathioninuria 8.0
colon neoplasm 8.0
Lymphoblastic lymphoma 7.9
vitamin B12 deficiency 7.7
Protein S deficiency 7.7
choline deficiency 7.6
MEST 7.5
Acute encephalopathy 7.5
PC deficiency 7.5
Cerebral venous thrombosis 7.5
Central retinal artery occlusion 7.5
trisomy 2 7.5
mesenteric thrombosis 7.5
childhood NHL 7.4
childhood ALL 7.4
Retinal vein occlusion 7.3
riboflavin deficiency 7.3
Migraine with aura 7.2
alcohol effect 7.1
megaloblastic anemia 6.9
PLAT 6.9
optic nerve glioma 6.9
favism 6.9
unilateral blindness 6.9
Demented 6.8
methylmalonic acidemia 6.8
adult ALL 6.7
Acute mesenteric ischemia 6.6
encephalomalacia 6.6
lymphoblastoma 6.6
Squamous Cell Carcinoma 6.6
abruptio placentae 6.6
TMN 6.6
idiopathic disorder 6.5
Pulmonary thromboembolism 6.5
Diabetic peripheral neuropathy 6.5
pyruvate kinase deficiency 6.5
Perthes disease 6.4
FHM 6.4
vascular disease 6.3
cerebral thrombosis 6.3
coprophagy 6.3
chromosome disorder 6.3
Ischemic stroke 6.2
hypertension in pregnancy 6.2
menstrual migraine 6.2
cleft lip/palate 6.1
thalassemia minor 6.1
FRAXA 6.0
vitamin B6 deficiency 6.0
stage IV NSCLC 6.0
Budd-Chiari syndrome 5.9
arachnodactyly 5.9
Portal vein thrombosis 5.9
venous stasis 5.9
Deep vein thrombosis 5.8
secondary polycythemia 5.8
eclampsia 5.8
APOA1 5.8
ischemic optic neuropathy 5.7
CIN II 5.7
CIN 1 5.7
hemiplegic migraine 5.7
perforated duodenal ulcer 5.7
Chimera 5.6
habitual abortion 5.6
deep vein thrombosis 5.6
male infertility 5.6
hypertensive retinopathy 5.6
Meningioma 5.5
Meningioma 5.5
postmenopausal bone loss 5.5
LCP 5.4
acute lymphoblastic leukemia 5.4
Primary open-angle glaucoma 5.4
oligospermia 5.3
Vascular dementia 5.3
Hepatotoxicity 5.3
bilateral breast cancer 5.3
preeclampsia 5.3
CIN I 5.3
complicated pregnancy 5.3
cardiovascular risk factor 5.3
Wolfram syndrome 5.3
Hereditary spastic paraplegia 5.3
FFI 5.2
Essential tremor 5.2
Down syndrome 5.2
primary central nervous system lymphoma 5.2
unipolar depression 5.2
amaurosis 5.2
XPD 5.1
beta thalassemia 5.1
Headache Disorders 5.1
RDA 5.1
azoospermia 5.1
WMS 5.0
WMS 5.0
Alcoholic liver disease 5.0
leukoencephalopathy 5.0
Erdheim-Chester disease 4.9
Ludwig 4.9
HNPCC 4.9
lupus 4.9
FHA 4.8
cholesterolemia 4.8
cardiovascular disease 4.8
coronary artery disease 4.8
Angelman syndrome 4.8
scalded skin syndrome 4.8
Peripheral arterial disease 4.8
HELLP syndrome 4.8
hypovitaminosis 4.7
acute chest syndrome 4.7
transient ischemic attack 4.7
CIN 4.6
Esophageal adenocarcinoma 4.6
peripheral vascular disease 4.6
antiphospholipid syndrome 4.6
Focal segmental glomerulosclerosis 4.6
arteriosclerosis 4.6
Endothelial dysfunction 4.6
gastrointestinal infection 4.5
cleft palate 4.5
cerebral infarction 4.5
hand-foot syndrome 4.5
Esophageal squamous cell carcinoma 4.5
developmental delay 4.5
pulmonary embolism 4.5
enzyme deficiency 4.5
migraine 4.4
MMA 4.4
colorectal cancer 4.4
severe mental retardation 4.4
schizoaffective disorder 4.4
melancholia 4.4
lupus 4.4
Thrombus 4.4
more...
Symptom
Livedoid 8.2
photopsia 6.8
hand pain 6.2
inanition 6.1
metamorphopsia 5.9
Decreased activity 4.8
limb pain 4.5
paraparesis 4.0
hypotonia 3.7
hypertonia 3.6
dysarthria 3.6
photophobia 3.3
spasticity 2.8
spasm 2.6
pallor 2.6
numbness 2.5
overweight 2.5
headache 2.3
ataxia 2.2
memory loss 2.1
cyanosis 2.0
neck pain 1.9
hemiplegia 1.9
tremor 1.7
angina 1.5
seizures 1.5
cachexia 1.4
lethargy 1.4
hepatomegaly 1.4
paresis 1.4
nausea 1.4
hemoptysis 1.3
abdominal pain 1.3
vomiting 1.2
weakness 1.0
chest pain 0.8
dizziness 0.6
fatigue 0.5
insomnia 0.5
cough 0.3
stigma 0.2
anorexia 0.1
dyspnea 0.1
hypothermia -0.2
pain -1.1
diarrhea -1.9
anesthesia -2.9
Drug
Folic Acid 8.9
Hakka 8.6
Lamisil 7.7
Lamisil 7.6
Vitamin B12 7.5
Cobalamin 7.4
Deoxyadenosine 6.9
GVG 6.5
Vitamin B 5.9
Pyridoxal 5.9
pyridoxal phosphate 5.7
THF 5.6
Gemfibrozil 5.5
FAD 5.4
Pemetrexed 5.2
Leucovorin 4.9
Troglitazone 4.8
Fragment 4.7
Riboflavin 4.3
TEL 4.3
Bevacizumab 4.1
Oxaliplatin 4.0
DDAVP 4.0
DDAVP 3.9
Arsenic trioxide 3.6
CTA 3.4
TAC 3.2
Simvastatin 3.2
Amiloride 3.1
Fructose 3.0
Paraffin 2.8
NADH 2.8
MDS 2.8
AZT 2.5
Fluorescein 2.5
AZT 2.3
Fluorescein 2.0
niacin 2.0
Portal 1.8
CTX 1.6
CSF 1.5
ICI 1.5
CTX 1.4
CTX 1.4
vitamin E 1.4
Nephron 1.3
Nephron 1.3
Indomethacin 1.3
PTH 1.1
ascorbate 1.0
ENT 0.8
Monit 0.8
Ethanol 0.6
Asn 0.4
lysine 0.4
ROS -0.4
Cardiovasc -0.4
Leaf -0.5
IL-2 -1.0
Dermatol -3.1
Enzyme
methylenetetrahydrofolate reductase 13.9
methylenetetrahydrofolate reductase 13.9
methionine synthase reductase 12.7
methylenetetrahydrofolate dehydrogenase 11.8
methylenetetrahydrofolate dehydrogenase 11.7
methionine synthase 11.4
methionine synthase 11.3
5,10-methenyltetrahydrofolate synthetase 10.9
homocysteine methyltransferase 10.7
formyltetrahydrofolate synthetase 10.4
cystathionine beta-synthase 9.9
glutamate formiminotransferase 9.9
10-formyltetrahydrofolate dehydrogenase 9.4
choline dehydrogenase 9.2
betaine-homocysteine methyltransferase 9.1
cyclohydrolase 9.1
AICAR transformylase 9.1
serine hydroxymethyltransferase 8.9
homoserine transacetylase 8.8
formylmethanofuran dehydrogenase 8.8
cystathionine gamma-synthase 8.7
dimethylglycine dehydrogenase 8.6
glycine N-methyltransferase 8.6
caffeoyl-CoA O-methyltransferase 8.5
thymidylate synthase 8.4
phosphatidylethanolamine N-methyltransferase 8.4
methionine adenosyltransferase 8.3
dihydropyrimidine dehydrogenase 8.1
sarcosine dehydrogenase 8.1
carboxypeptidase G2 8.0
histone-lysine N-methyltransferase 7.9
thiopurine methyltransferase 7.8
dihydropyrimidine dehydrogenase 7.7
glycinamide ribonucleotide transformylase 7.7
CSAD 7.6
bleomycin hydrolase 7.5
folylpolyglutamate synthetase 7.4
nicotinamide N-methyltransferase 7.3
conjugase 7.3
heterodisulfide reductase 7.3
methionyl-tRNA synthetase 6.9
cystathionine gamma-lyase 6.8
guanidinoacetate methyltransferase 6.8
inosine triphosphatase 6.6
jararhagin 6.6
methyl coenzyme M reductase 6.5
APC 6.2
cysteine dioxygenase 6.1
PRT 6.1
dihydrofolate reductase 6.0
LexA repressor 6.0
thrombin-activatable fibrinolysis inhibitor 5.9
AGT 5.9
thymidine phosphorylase 5.9
ADH3 5.8
S-adenosyl-L-homocysteine hydrolase 5.8
paraoxonase 5.5
proprotein convertase 5.4
catechol O-methyltransferase 5.3
paraoxonase 5.2
choline kinase 5.1
lactonase 5.0
acetate kinase 5.0
PTA 4.7
glycine decarboxylase 4.7
prostate-specific membrane antigen 4.7
lysyl oxidase 4.6
aldehyde dehydrogenase 4.6
aldehyde dehydrogenase 4.6
aldehyde dehydrogenase 4.6
aldehyde dehydrogenase 4.5
GTP cyclohydrolase I 4.5
cholesterol acyltransferase 4.5
NQO1 4.5
dopamine beta-hydroxylase 4.4
fatty acid desaturase 4.4
glycerol kinase 4.4
aldehyde oxidase 4.4
microsomal epoxide hydrolase 4.2
ACE 4.2
S-adenosylmethionine decarboxylase 4.1
asparaginase 4.1
delta-aminolevulinic acid dehydratase 4.0
aldehyde dehydrogenase 4.0
CYP7A1 3.9
formate dehydrogenase 3.9
formate dehydrogenase 3.9
furin 3.8
formate dehydrogenase 3.8
UDP-glucuronosyltransferase 3.8
flavin-containing monooxygenase 3.8
lecithin:cholesterol acyltransferase 3.6
DNA methyltransferase 3.6
glutathione S-transferase 3.6
phenylalanine hydroxylase 3.4
PGM 3.4
gamma-glutamylcysteine synthetase 3.4
CAD 3.4
subtilisin 3.4
CAD 3.4
protein phosphatase 2A 3.3
pyruvate carboxylase 3.3
CAD 3.3
polo-like kinase 1 3.3
tissue plasminogen activator 3.2
AOR 3.1
tryptophan hydroxylase 3.1
TdT 3.0
glutathione reductase 3.0
diaphorase 2.9
cathepsin D 2.9
lactase 2.8
chaperonin 2.8
N-acetyltransferase 2.7
sucrase 2.6
glucose-6-phosphate dehydrogenase 2.5
DNA ligase 2.5
DNA ligase 2.5
diaphorase 2.5
thrombin 2.4
ribonucleotide reductase 2.3
glucose-6-phosphatase 2.3
alcohol dehydrogenase 2.3
aldose reductase 2.2
calcineurin 2.1
lipoprotein lipase 2.1
aspartate aminotransferase 2.1
NADPH-diaphorase 1.9
phosphoenolpyruvate carboxykinase 1.8
phosphoenolpyruvate carboxykinase 1.8
thromboplastin 1.8
P-glycoprotein 1.8
phosphoenolpyruvate carboxykinase 1.7
endonuclease 1.7
lipase 1.7
invertase 1.6
phosphorylase 1.4
kallikrein 1.3
AST 1.3
choline acetyltransferase 1.3
GSK 1.1
phospholipase A2 1.1
NOS 1.0
DNA polymerase 0.8
lipoxygenase 0.8
renin 0.8
gamma-glutamyl transpeptidase 0.7
phosphodiesterase 0.7
creatine kinase 0.7
transcriptase 0.7
urokinase-type plasminogen activator 0.5
monoamine oxidase 0.5
lysozyme 0.5
glutathione peroxidase 0.5
cholinesterase 0.2
alanine aminotransferase 0.2
ERK 0.1
lactate dehydrogenase 0.0
beta-galactosidase 0.0
focal adhesion kinase 0.0
more...
Compound
Menoctone 11.9
homocysteine 10.0
Homocysteine 9.9
Homocysteine 9.9
CH3-THF 9.6
5,10-methenyltetrahydrofolate 9.5
PGA 8.7
Diamant 8.5
Thiouracil 8.3
Tetrahydrocurcumin 8.2
5,10-methylene-THF 7.9
5-formyltetrahydrofolate 7.9
Benazepril 7.8
dUMP 7.5
Cobalamin 7.4
10-formyltetrahydrofolate 7.2
betaine 7.2
Deoxyadenosine 7.0
adenosylmethionine 7.0
S-adenosylhomocysteine 6.9
Cystathionine 6.7
C 10 6.7
C 10 6.7
Cystathionine 6.7
TCN 6.6
CBS 6.5
11-dehydro-thromboxane 6.3
Methionine 6.3
folinic acid 6.1
Choline 6.0
dihydrofolate 6.0
methionine 5.9
Methotrexate 5.9
Pyridoxal 5.8
Bantu 5.7
Glycine, 5.6
pentosidine 5.6
TMP 5.6
TIB 5.5
TDT 5.5
FAD 5.4
CoM 5.4
Pyridoxine 5.3
Glycine, 5.3
TBE 5.2
Formate 5.2
norvaline 5.1
norvaline 5.1
Sulfasalazine 5.1
dimethylarsinic acid 5.0
dimethylarsinic acid 5.0
dimethylarsinic acid 5.0
dimethylarsinic acid 5.0
dimethylarsinic acid 5.0
PDT 4.9
Azathioprine 4.9
Acyl-CoA 4.9
Valproic acid 4.9
Capecitabine 4.8
Valine 4.8
dimethylarsinic acid 4.8
valine 4.8
PLP 4.8
Arsenite 4.6
EPC 4.5
MMA 4.4
MTX 4.4
HBB 4.4
Uracil 4.3
pteridine 4.3
TEL 4.2
Riboflavin 4.2
d4T 4.2
SAH 4.2
MMA 4.2
HCA 4.2
Valproic acid 4.2
MMA 4.1
nicotinic acid 4.1
Warfarin 4.1
5-FU 4.1
Evans Blue 4.1
Purine 4.0
DMA 4.0
DMA 3.9
Paraquat 3.9
FAP 3.9
FAP 3.9
T 1 3.9
Creatine 3.8
Paraquat 3.8
HCB 3.7
DMA 3.7
Coenzyme Q10 3.7
Statin 3.6
Lignin 3.5
Benzene 3.4
Agarose 3.4
AICAR 3.3
FMN 3.3
L-threonine 3.3
CPA 3.3
creatinine 3.2
alanine 3.2
Phosphatidylcholine 3.2
CPA 3.2
CPA 3.1
NADPH 3.1
NADPH 3.1
Hemoglobin 3.1
H2S 3.0
Abbott 3.0
MSM 3.0
DBP 3.0
hydroxyindoleacetic acid 2.9
MCP 2.9
Fructose 2.9
nicotinamide 2.9
CPA 2.9
neopterin 2.9
Genistein 2.9
THF 2.8
prostaglandin F2alpha 2.8
NADH 2.8
DBP 2.8
Heparin 2.8
NADP 2.7
Taurine 2.7
ASC 2.7
T10 2.7
coenzyme Q10 2.7
Parenteral 2.6
DNA 2.6
dUTP 2.6
TBI 2.5
formaldehyde 2.5
H2S 2.5
naphthoquinone 2.4
naphthoquinone 2.4
naphthoquinone 2.4
naphthoquinone 2.4
naphthoquinone 2.4
TTP 2.4
naphthoquinone 2.4
Pac 2.4
formaldehyde 2.4
alcohol dehydrogenase 2.4
NAD 2.4
Ascorbic acid 2.4
naphthoquinone 2.4
A 42 2.4
AAA 2.4
nicotinic acid 2.3
nicotinic acid 2.3
L-DOPA 2.3
homoserine 2.3
homoserine 2.3
homoserine 2.3
nicotinic acid 2.3
5-hydroxytryptophan 2.2
more...