Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.7.1 (methylenetetrahydrofolate reductase)
 2,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
methylenetetrahydrofolate reductase 2013
5,10-methylenetetrahydrofolate reductase 299
MTHFR 230
prothrombin 193
Mol 172
B12 164
factor V Leiden 162
Sep 151
methionine synthase 150
methionine synthase reductase 94
factor V 87
MTRR 83
thymidylate synthase 82
MTR 71
cystathionine beta-synthase 63
protein C 63
protein S 56
plasminogen activator inhibitor-1 53
reduced folate carrier 45
plasminogen activator inhibitor 40
fibrinogen 33
methylenetetrahydrofolate dehydrogenase 33
antithrombin 33
apolipoprotein E 27
methyltransferase 26
reductase 25
dihydrofolate reductase 24
antithrombin III 23
CBS 23
Methylenetetrahydrofolate reductase 23
insulin 21
Polymerase 20
C-reactive protein 18
serine hydroxymethyltransferase 17
She 17
glutathione S-transferase 17
UTR 17
factor VIII 17
dihydropyrimidine dehydrogenase 17
cystathionine-beta-synthase 16
SAM 16
glycoprotein 16
HDL 16
endothelial nitric oxide synthase 15
MTHFD1 15
FAD 15
MRI 14
NADPH 14
B-12 14
hemoglobin 13
SLC19A1 13
GSTT1 13
RFC 13
ANOVA 12
RFC1 12
GSTM1 12
thrombin 12
apolipoprotein 12
factor VII 11
angiotensinogen 11
5-methyltetrahydrofolate-homocysteine methyltransferase 11
Lp(a) 10
Met 10
NADH 10
TYMS 10
catechol-O-methyltransferase 10
thymidylate synthetase 10
p53 10
CRP 10
FOLR1 10
albumin 10
APOE 9
GSTP1 9
plasminogen 9
SHMT1 8
coagulation factor V 8
cytokine 8
flavoprotein 8
RFC) 8
glycoprotein IIIa 8
transcobalamin II 8
eNOS 8
aldehyde dehydrogenase 7
1A1 7
NAD 7
IL-6 7
collagen 7
APC 7
ITGB3 7
beta-fibrinogen 7
ACE 7
vitamin D receptor 6
CSF 6
thiopurine methyltransferase 6
oxidoreductase 6
HLA 6
apoE 6
angiotensin II 6
S-adenosylhomocysteine hydrolase 6
thrombomodulin 6
Prothrombin 6
von Willebrand factor 6
Pol 6
ARMS 6
cytochrome P450 6
TCN2 6
chronic renal failure 6
formyltetrahydrofolate synthetase 6
folate receptor 6
Angiotensin-converting enzyme 5
vascular endothelial growth factor 5
Gen 5
tumor necrosis factor 5
hormone receptor 5
LDL receptor 5
p16 5
Glycine N-methyltransferase 5
CYP1A1 5
kit 5
VIII 5
glutathione reductase 5
aspartate aminotransferase 5
ATP 5
ERCC1 5
methylenetetrahydrofolate dehydrogenase 1 5
DHFR 5
cyclin D1 5
paraoxonase 5
chromosome 21 5
polypeptide 4
PAI 4
non-Hodgkin's lymphoma 4
adiponectin 4
NOS3 4
proinsulin 4
NADP 4
folylpolyglutamate synthetase 4
cystathionine gamma-lyase 4
HFE 4
PLA 4
PON1 4
NQO1 4
DNA methyltransferase 4
tissue plasminogen activator 4
ATPase 4
low density lipoprotein receptor 4
COMT 4
interleukin-6 4
DNMT1 4
superoxide dismutase 4
apolipoprotein B 4
factor XI 4
cytochrome P-450 4
BHMT 4
brain-derived neurotrophic factor 4
MDR1 4
betaine-homocysteine methyltransferase 4
endonuclease 4
Men 4
ESR1 4
more...
Disease
hyperhomocysteinemia 327
cancer 234
stroke 163
cardiovascular disease 125
atherosclerosis 92
vascular disease 92
coronary artery disease 85
hypertension 83
colorectal cancer 75
tumor 69
acute lymphoblastic leukemia 59
breast cancer 58
folate deficiency 58
diabetes 58
carcinogenesis 56
homocystinuria 54
schizophrenia 53
myocardial infarction 48
deep vein thrombosis 39
preeclampsia 38
Alzheimer's disease 35
Down syndrome 35
systemic lupus erythematosus 34
abortion 32
lupus 31
lymphoma 31
lupus 30
renal disease 30
childhood ALL 27
obesity 27
dementia 25
rheumatoid arthritis 25
migraine 24
pulmonary embolism 22
gastric cancer 22
leukemia 21
coronary heart disease 20
Thrombophilia 20
colon cancer 19
osteoporosis 19
cognitive impairment 18
vitamin B12 deficiency 17
metabolic syndrome 17
male infertility 17
type 2 diabetes 16
cleft palate 16
infertility 16
lung cancer 16
Parkinson's disease 15
carcinoma 15
acute myocardial infarction 14
sickle cell disease 14
depression 14
epilepsy 14
malnutrition 14
adenoma 14
renal failure 13
diabetic nephropathy 13
anemia 13
heart disease 13
bipolar disorder 12
essential hypertension 12
developmental delay 12
cerebral infarction 11
hepatocellular carcinoma 11
megaloblastic anemia 10
squamous cell carcinoma 10
tumorigenesis 10
arteriosclerosis 9
cirrhosis 9
adenocarcinoma 9
eclampsia 9
autism 9
plaque 9
psychosis 9
multiple myeloma 8
retinopathy 8
bladder cancer 8
polycystic ovary syndrome 8
thrombocytopenia 8
fits 8
cerebral ischemia 8
rectal cancer 8
B-cell lymphoma 8
antiphospholipid syndrome 8
transient ischemic attack 8
azoospermia 8
CBS deficiency 8
neutropenia 8
hemiparesis 8
myocardial ischemia 8
prostate cancer 8
genetic disorder 8
mental illness 7
Factor V Leiden mutation 7
inflammatory bowel disease 7
APC 7
Ischemic stroke 7
West 7
chronic renal failure 7
peripheral vascular disease 7
fatty liver 7
abdominal aortic aneurysm 7
mental retardation 7
thalassemia 7
hyperlipidemia 7
acute myeloid leukemia 7
hypercholesterolemia 7
malabsorption 7
ischemia 7
mental retardation 7
neurological disease 6
multiple sclerosis 6
dyslipidemia 6
cervical intraepithelial neoplasia 6
diabetic retinopathy 6
ovarian cancer 6
Budd-Chiari syndrome 6
major depressive disorder 6
memory impairment 6
Hodgkin's disease 6
neuropathy 5
graft-versus-host disease 5
Autism 5
sensorineural hearing loss 5
vasculitis 5
type 1 diabetes 5
cardiovascular risk factor 5
Activated protein C resistance 5
leukoencephalopathy 5
esophageal cancer 5
methylmalonic acidemia 5
oral cancer 5
childhood cancer 5
chronic myeloid leukemia 5
adult ALL 5
follicular lymphoma 5
peripheral neuropathy 5
coagulopathy 5
proteinuria 4
alcoholism 4
cervical cancer 4
pancreatic cancer 4
venous stasis 4
metabolic disorder 4
metastases 4
renal impairment 4
glaucoma 4
chronic hepatitis 4
non-small cell lung cancer 4
chronic disease 4
acute leukemia 4
abruptio placentae 4
hemolytic uremic syndrome 4
esophageal cancer 4
encephalopathy 4
non-Hodgkin's lymphoma 4
heart failure 4
psoriasis 4
leukopenia 4
more...
Symptom
headache 18
seizures 15
overweight 10
pain 8
hypotonia 5
fatigue 5
ataxia 5
vomiting 5
abdominal pain 5
weakness 5
tremor 4
angina 4
nausea 4
spasm 3
paraparesis 3
spasticity 3
dysarthria 3
dyspnea 2
chest pain 2
numbness 2
cough 2
metamorphopsia 1
hemoptysis 1
anesthesia 1
hand pain 1
hypothermia 1
limb pain 1
photophobia 1
pallor 1
hepatomegaly 1
cachexia 1
hypertonia 1
paresis 1
stigma 1
anorexia 1
neck pain 1
cyanosis 1
lethargy 1
diarrhea 1
insomnia 1
photopsia 1
dizziness 1
memory loss 1
inanition 1
Decreased activity 1
hemiplegia 1
Livedoid 1
Drug
THF 26
FAD 15
Vitamin B12 15
Cardiovasc 10
NADH 10
pyridoxal phosphate 9
CSF 6
lysine 5
Vitamin B 5
Fragment 4
Monit 4
vitamin E 3
Nephron 3
ascorbate 3
Cobalamin 3
Dermatol 2
CTX 2
Bevacizumab 2
Hakka 2
Nephron 2
Folic Acid 2
CTX 1
CTA 1
DDAVP 1
Gemfibrozil 1
MDS 1
Asn 1
CTX 1
Indomethacin 1
Pyridoxal 1
GVG 1
TEL 1
niacin 1
Arsenic trioxide 1
Lamisil 1
IL-2 1
Fructose 1
DDAVP 1
TAC 1
Fluorescein 1
Deoxyadenosine 1
Ethanol 1
ICI 1
AZT 1
Amiloride 1
Pemetrexed 1
ENT 1
Oxaliplatin 1
Portal 1
Paraffin 1
Fluorescein 1
PTH 1
ROS 1
Leucovorin 1
Troglitazone 1
Riboflavin 1
Lamisil 1
Leaf 1
Simvastatin 1
AZT 1
Enzyme
methylenetetrahydrofolate reductase 2116
methylenetetrahydrofolate reductase 2116
methionine synthase 152
methionine synthase 147
methionine synthase reductase 89
thymidylate synthase 83
APC 80
cystathionine beta-synthase 63
methylenetetrahydrofolate dehydrogenase 33
methylenetetrahydrofolate dehydrogenase 26
dihydrofolate reductase 25
ACE 22
serine hydroxymethyltransferase 19
glutathione S-transferase 18
homocysteine methyltransferase 18
dihydropyrimidine dehydrogenase 17
cyclohydrolase 16
dihydropyrimidine dehydrogenase 15
methionine adenosyltransferase 14
formyltetrahydrofolate synthetase 13
thrombin 12
NQO1 9
thiopurine methyltransferase 8
aldehyde dehydrogenase 8
ERK 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
tissue plasminogen activator 7
aldehyde dehydrogenase 7
betaine-homocysteine methyltransferase 6
aspartate aminotransferase 6
glutathione reductase 5
paraoxonase 5
cystathionine gamma-synthase 5
calcineurin 5
paraoxonase 5
phosphatidylethanolamine N-methyltransferase 5
renin 4
endonuclease 4
folylpolyglutamate synthetase 4
cystathionine gamma-lyase 4
DNA methyltransferase 4
glycine N-methyltransferase 4
lipase 4
superoxide dismutase 4
ATPase 4
thymidine phosphorylase 4
peroxidase 3
P-glycoprotein 3
CAD 3
CAD 3
CAD 3
thromboplastin 3
proprotein convertase 3
subtilisin 3
carboxypeptidase G2 3
PTA 3
glucose-6-phosphate dehydrogenase 3
choline dehydrogenase 3
focal adhesion kinase 3
AGT 3
diaphorase 3
furin 3
prostate-specific membrane antigen 3
methionyl-tRNA synthetase 3
5,10-methenyltetrahydrofolate synthetase 3
UDP-glucuronosyltransferase 3
conjugase 3
alkaline phosphatase 3
asparaginase 3
alcohol dehydrogenase 3
cholesterol acyltransferase 3
10-formyltetrahydrofolate dehydrogenase 3
lactate dehydrogenase 2
protein phosphatase 2A 2
lipoprotein lipase 2
dopamine beta-hydroxylase 2
lysozyme 2
alanine aminotransferase 2
creatine kinase 2
cathepsin D 2
glutathione peroxidase 2
catalase 2
protein kinase C 2
phosphodiesterase 2
phospholipase A2 2
glycinamide ribonucleotide transformylase 2
AICAR transformylase 2
lysyl oxidase 2
DNA polymerase 2
phosphoenolpyruvate carboxykinase 1
GSK 1
microsomal epoxide hydrolase 1
NADPH-diaphorase 1
kallikrein 1
TdT 1
GTP cyclohydrolase I 1
NOS 1
gamma-glutamyl transpeptidase 1
cholinesterase 1
trypsin 1
phosphoenolpyruvate carboxykinase 1
S-adenosylmethionine decarboxylase 1
lipoxygenase 1
acetate kinase 1
choline acetyltransferase 1
inosine triphosphatase 1
formylmethanofuran dehydrogenase 1
transcriptase 1
reverse transcriptase 1
homoserine transacetylase 1
lecithin:cholesterol acyltransferase 1
guanidinoacetate methyltransferase 1
heterodisulfide reductase 1
formate dehydrogenase 1
CYP7A1 1
delta-aminolevulinic acid dehydratase 1
bleomycin hydrolase 1
beta-galactosidase 1
lactonase 1
chaperonin 1
AST 1
histone-lysine N-methyltransferase 1
invertase 1
phosphorylase 1
sucrase 1
PGM 1
flavin-containing monooxygenase 1
caspase-3 1
nicotinamide N-methyltransferase 1
aldose reductase 1
dimethylglycine dehydrogenase 1
protein kinase 1
sarcosine dehydrogenase 1
glucose-6-phosphatase 1
urokinase-type plasminogen activator 1
AOR 1
N-acetyltransferase 1
caffeoyl-CoA O-methyltransferase 1
tryptophan hydroxylase 1
formate dehydrogenase 1
catechol O-methyltransferase 1
NO synthase 1
diaphorase 1
methyl coenzyme M reductase 1
proteasome 1
LexA repressor 1
PRT 1
gamma-glutamylcysteine synthetase 1
monoamine oxidase 1
polo-like kinase 1 1
CSAD 1
S-adenosyl-L-homocysteine hydrolase 1
ribonucleotide reductase 1
formate dehydrogenase 1
glycine decarboxylase 1
glutamate formiminotransferase 1
phosphoenolpyruvate carboxykinase 1
tyrosine hydroxylase 1
more...
Compound
homocysteine 780
DNA 337
methionine 241
Dec 164
Clin 160
PGA 127
Homocysteine 83
Homocysteine 83
adenosylmethionine 71
betaine 46
alanine 44
creatinine 37
valine 27
Cardiol 25
CBS 23
S-adenosylhomocysteine 22
glucose 21
water 21
Methotrexate 20
cysteine 20
serine 19
oxygen 18
FAD 16
NADPH 14
His 14
NADPH 14
nitric oxide 13
calcium 12
CH3-THF 12
Pac 12
acetate 11
sodium 11
phosphate 11
Methionine 10
glutamate 10
NADH 10
5,10-methenyltetrahydrofolate 9
TMP 9
urea 8
folinic acid 8
arginine 8
dUMP 8
5-FU 8
Choline 8
NAD 8
nicotinamide 8
lysine 7
vitamin D 7
formaldehyde 7
NAD 7
5-formyltetrahydrofolate 7
hydrogen 7
ethanol 7
formaldehyde 6
nicotinic acid 5
sulfate 5
threonine 5
leucine 5
CO2 5
pyrimidine 5
NADP 5
ATP 5
pyrimidine 5
uridine 4
Hemoglobin 4
tryptophan 4
aldosterone 4
tryptophan 4
Gly 4
tryptophan 4
iron 4
H2S 4
Valproic acid 4
tryptophan 4
dihydrofolate 4
Asp 4
PDT 3
Optimal 3
isoleucine 3
PLP 3
L-DOPA 3
Heparin 3
Warfarin 3
THF 3
zinc 3
dUTP 3
alcohol dehydrogenase 3
Ile 3
Cholesterol 3
EDTA 3
salt 3
MTX 3
Phe 3
nitrogen 3
H2S 3
Cobalamin 3
DSM 3
MMA 3
EDTA 3
isoleucine 3
GSH 2
benzene 2
Valproic acid 2
5-HT 2
Ascorbic acid 2
Azathioprine 2
GABA 2
Cystathionine 2
aspartic acid 2
hydroxyindoleacetic acid 2
Insulin 2
pentosidine 2
Formate 2
Abbott 2
copper 2
dimethylarsinic acid 2
DMA 2
dimethylarsinic acid 2
aspartic acid 2
DMA 2
methane 2
Angiotensin II 2
dimethylarsinic acid 2
DBP 2
aspartic acid 2
noradrenaline 2
10-formyltetrahydrofolate 2
dimethylarsinic acid 2
Bantu 2
DMA 2
TNF 2
CTX 2
TOF 2
tyrosine 2
MMA 2
GSH 2
DBP 2
MMA 2
dimethylarsinic acid 2
nickel 2
proline 2
THF 2
Cystathionine 2
ammonia 2
glutamine 2
dimethylarsinic acid 2
FMN 2
GABA 2
aspartic acid 2
PMA 2
glutamic acid 1
Norepinephrine 1
gamma-aminobutyric acid 1
PGE 1
Evans Blue 1
C 10 1
CPA 1
Letter 1
SAH 1
cAMP 1
more...