Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.7.1 (methylenetetrahydrofolate reductase)
 2,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
methylenetetrahydrofolate reductase 2013
5,10-methylenetetrahydrofolate reductase 299
MTHFR 230
prothrombin 193
Mol 172
B12 164
factor V Leiden 162
Sep 151
methionine synthase 150
methionine synthase reductase 94
factor V 87
MTRR 83
thymidylate synthase 82
MTR 71
protein C 63
cystathionine beta-synthase 63
protein S 56
plasminogen activator inhibitor-1 53
reduced folate carrier 45
plasminogen activator inhibitor 40
fibrinogen 33
methylenetetrahydrofolate dehydrogenase 33
antithrombin 33
apolipoprotein E 27
methyltransferase 26
reductase 25
dihydrofolate reductase 24
Methylenetetrahydrofolate reductase 23
CBS 23
antithrombin III 23
insulin 21
Polymerase 20
C-reactive protein 18
She 17
UTR 17
dihydropyrimidine dehydrogenase 17
serine hydroxymethyltransferase 17
glutathione S-transferase 17
factor VIII 17
glycoprotein 16
SAM 16
cystathionine-beta-synthase 16
HDL 16
MTHFD1 15
endothelial nitric oxide synthase 15
FAD 15
NADPH 14
MRI 14
B-12 14
GSTT1 13
RFC 13
SLC19A1 13
hemoglobin 13
GSTM1 12
thrombin 12
ANOVA 12
RFC1 12
apolipoprotein 12
5-methyltetrahydrofolate-homocysteine methyltransferase 11
factor VII 11
angiotensinogen 11
p53 10
thymidylate synthetase 10
FOLR1 10
CRP 10
Met 10
Lp(a) 10
TYMS 10
albumin 10
catechol-O-methyltransferase 10
NADH 10
plasminogen 9
GSTP1 9
APOE 9
SHMT1 8
RFC) 8
glycoprotein IIIa 8
coagulation factor V 8
transcobalamin II 8
flavoprotein 8
cytokine 8
eNOS 8
beta-fibrinogen 7
ACE 7
aldehyde dehydrogenase 7
IL-6 7
collagen 7
1A1 7
APC 7
NAD 7
ITGB3 7
ARMS 6
Pol 6
HLA 6
von Willebrand factor 6
folate receptor 6
CSF 6
cytochrome P450 6
vitamin D receptor 6
S-adenosylhomocysteine hydrolase 6
angiotensin II 6
thiopurine methyltransferase 6
apoE 6
Prothrombin 6
TCN2 6
thrombomodulin 6
oxidoreductase 6
formyltetrahydrofolate synthetase 6
chronic renal failure 6
Glycine N-methyltransferase 5
Gen 5
chromosome 21 5
glutathione reductase 5
LDL receptor 5
ERCC1 5
vascular endothelial growth factor 5
VIII 5
cyclin D1 5
DHFR 5
p16 5
hormone receptor 5
CYP1A1 5
aspartate aminotransferase 5
kit 5
ATP 5
tumor necrosis factor 5
methylenetetrahydrofolate dehydrogenase 1 5
Angiotensin-converting enzyme 5
paraoxonase 5
tissue plasminogen activator 4
PLA 4
folylpolyglutamate synthetase 4
XRCC1 4
MDR1 4
MMACHC 4
endonuclease 4
DNMT1 4
interleukin-6 4
cystathionine gamma-lyase 4
NQO1 4
non-Hodgkin's lymphoma 4
ESR1 4
cytochrome P-450 4
adiponectin 4
thymidine phosphorylase 4
factor XI 4
serine hydroxymethyltransferase 1 4
DNA methyltransferase 4
HFE 4
ATPase 4
NADP 4
renin 4
COMT 4
phosphatidylethanolamine N-methyltransferase 4
proinsulin 4
NOS3 4
Men 4
brain-derived neurotrophic factor 4
superoxide dismutase 4
PAI 4
polypeptide 4
betaine-homocysteine methyltransferase 4
low density lipoprotein receptor 4
BHMT 4
PON1 4
apolipoprotein B 4
gut 3
CAD 3
GPIIb 3
p14 3
alkaline phosphatase 3
MRP1 3
PPARD 3
oestrogen receptor 3
ERCC4 3
MAT2A 3
NAT2 3
MTX 3
AT1 3
novel gene 3
cytoplasmic serine hydroxymethyltransferase 3
methionyl-tRNA synthetase 3
P450 3
PRISM 3
DNMT3B 3
LIPC 3
CYP1A2 3
ATP-binding cassette transporter A1 3
paraoxonase 1 3
nitric oxide synthase 3
dilute 3
peroxisome proliferator-activated receptor gamma 3
hepatic lipase 3
choline dehydrogenase 3
threonine 3
AGT 3
caldesmon 3
P-glycoprotein 3
tissue factor 3
ferredoxin 3
MTHFS 3
ALL 3
alcohol dehydrogenase 3
dimeric 3
PLP 3
proton-coupled folate transporter 3
LIF 3
thromboplastin 3
JAK2 3
cholesteryl ester transfer protein 3
amyloid precursor protein 3
endothelial lipase 3
neu 3
TIM 3
GADD45 3
adenomatous polyposis coli 2
low-density lipoprotein receptor 2
ADH3 2
San 2
beta-globin 2
Q10 2
hMLH1 2
hemochromatosis 2
creatine kinase 2
CDKN2A 2
pseudogene 2
member 1 2
ADRB3 2
glutamate carboxypeptidase II 2
intrinsic factor 2
Factor VIII 2
TOF 2
CO2 2
VEGF 2
tissue factor pathway inhibitor 2
SHMT 2
CACNA1A 2
phospholipase A2 2
androgen receptor 2
Catechol-O-methyltransferase 2
NADH diaphorase 2
myeloperoxidase 2
glutamate-cysteine ligase 2
MAT1A 2
spermatozoa 2
API 2
Reelin 2
SBP 2
DBP 2
XRCC3 2
K-ras 2
FMRP 2
myelin basic protein 2
IL-4 2
peroxisome proliferator-activated receptor 2
caspase-3 2
c-myc 2
NSCL 2
cytochrome 2
lysyl oxidase 2
lymphoid 2
interacting protein 2
MEST 2
thiopurine S-methyltransferase 2
cathepsin D 2
myosin regulatory light chain 2
cubilin 2
cystatin C 2
elastin 2
Y chromosome 2
DRD2 2
insulin-like growth factor 2 2
Sp1 2
CIN 2
endothelial protein C receptor 2
ABCB1 2
STAT 2
catalase 2
MMP-2 2
colon carcinoma 2
TGFB1 2
FLAP 2
GSH 2
transforming growth factor alpha 2
PTA 2
Methionine adenosyltransferase 2
MMA 2
membrane-bound 2
glutathione-S-transferase M1 2
DNMT3A 2
DT-diaphorase 2
matrix metalloproteinase 2
glucuronosyltransferase 2
factor XII 2
lactate dehydrogenase 2
prostate-specific membrane antigen 2
formyltetrahydrofolate dehydrogenase 2
E-selectin 2
XPD 2
estrogen receptor 2
Ku86 2
UGT1A1 2
TNF-alpha 2
lipoprotein lipase 2
leptin 2
HTR2C 2
xenobiotic 2
DMA 2
ITGA2 2
transcriptional activator 2
neurofibromatosis type 1 2
E3 ubiquitin ligase 2
calcineurin 2
GSTO1 2
GST 2
CYP1B1 2
Serine hydroxymethyltransferase 2
Nicotinamide N-methyltransferase 2
glucose-6-phosphate dehydrogenase 2
IFN 2
methionine adenosyltransferase II 2
IL-10 2
beta2-glycoprotein I 2
dopamine beta-hydroxylase 2
phosphorylating 2
betaine homocysteine methyltransferase 2
erythrocyte glutathione peroxidase 2
lysozyme 2
interferon 2
folate-binding protein 2
cyclooxygenase-2 2
solute carrier 2
TNF 2
TGFBR2 2
CN2 2
cytosolic serine hydroxymethyltransferase 2
oxidized low-density lipoprotein receptor 2
epidermal growth factor receptor 2
quinone oxidoreductase 2
version 1 2
apolipoprotein A1 2
S protein 2
AT1R 2
GTL2 2
carnitine palmitoyltransferase 1A 2
GABA 2
HPA 2
phosphodiesterase 2
Protein S 2
ALDH2 2
glutathione peroxidase 2
GP1BA 2
human leukocyte antigen 2
IVF 2
MMP9 2
methylguanine-DNA methyltransferase 2
peptidase 1
c-Myc 1
von Willebrand factor-cleaving protease 1
cyclooxygenase 1
NR2A 1
multidrug resistance-associated protein 1
vascular endothelium 1
HNPCC 1
RET proto-oncogene 1
ornithine decarboxylase 1 1
MT1 1
glycine decarboxylase 1
RACE 1
PPARG 1
MLH1 1
InsP3R1 1
LC3 1
FMN 1
MAT2B 1
aldo-keto reductase 1
FOLR2 1
AS3MT 1
ANKK1 1
microsomal triglyceride transfer protein 1
SLCO1B1 1
Paraoxonase 1
HDL2 1
CTX 1
GGT 1
adrenergic, beta-3-, receptor 1
SPG 1
glutathione S-transferase class theta 1
TNF receptor 1
cblB 1
damage-regulated autophagy modulator 1
tyrosine kinase 3 1
membrane glycoprotein 1
LCT 1
APL 1
solute carrier family 6 member 4 1
APOC3 1
SLC6A4 1
PLA1 1
INK4a 1
microsomal epoxide hydrolase 1
ESX 1
CNTNAP4 1
disrupted in schizophrenia 1 1
complement factor H 1
natriuretic peptide 1
serotonin transporter 1
hemophilia A 1
IL-15 1
IL-18 1
mannose binding lectin 1
Msx2 1
HLA class II 1
factor XIIIa 1
c-fms 1
GTP cyclohydrolase I 1
IgA 1
SPA 1
G6Pase 1
granulocyte 1
bleomycin hydrolase 1
E-cadherin 1
interferon regulatory factor-1 1
endoplasmic reticulum 1
solute carrier family 19 member 1 1
SULT1A2 1
FVIII 1
POR 1
CD59 1
coagulation factor VIII 1
HER2 1
PCK1 1
cell adhesion molecule 1 1
HGF 1
microtubule-associated protein 1
kallikrein 1
ERK 1
prolyl-tRNA synthetase 1
choline kinase 1
CHC 1
dopamine D2 receptor 1
platelet factor 4 1
flavin-containing monooxygenase 1
CETP 1
tRNA 1
HTN 1
MDS 1
C protein 1
HAI 1
FilGAP 1
NET 1
FBP 1
GMA 1
bradykinin 1
CPS1 1
DRD4 1
D2R 1
E2F1 1
FLT3 receptor tyrosine kinase 1
CD14 1
ChAT 1
LSM2 1
PLA2 1
PLAGL1 1
WAVE 1
stromelysin 1
Tryptophan hydroxylase 1
interleukin 6 1
vasopressin 1
TGF-beta type II receptor 1
fibronectin 1
SAS 1
transforming growth factor beta receptor II 1
echinoderm microtubule-associated protein-like 1
PIQ 1
chaperonin 1
GCH1 1
AP1 1
factor H 1
thrombospondin 1
serine/threonine-protein kinase 1
SIDS 1
FDG 1
parathormone 1
cancer susceptibility 1
kallistatin 1
CPA 1
CENP-Q 1
GPI 1
osteoprotegerin 1
BCRP 1
TGFA 1
fidgetin 1
BAFF 1
IL-17F 1
chemokine 1
lymphotoxin 1
F13A1 1
NHL 1
Partitioning defective 3-like protein 1
X11 1
RUNX3 1
Choline acetyltransferase 1
PCI 1
Uracil-DNA glycosylase 1
DLD 1
ABR 1
PLAT 1
LCMT1 1
annexin A5 1
Engrailed-2 1
synaptophysin 1
ATP1A2 1
ASD 1
BRCA1 1
PTHR 1
TB2 1
acyl-CoA oxidase 1
HNF1A 1
SIRT1 1
thrombopoietin receptor 1
glucose-6-phosphatase 1
phenylalanine hydroxylase 1
Myf-6 1
MPL 1
cblA 1
ubiquinone 1
MCP 1
UGT 1
nephropathic cystinosis 1
lipase 1
Fe65 1
CAST 1
OPG 1
CXCL13 1
CPU 1
factor B 1
XIAP 1
CRH 1
retinoic acid receptor 1
IL12RB1 1
SAGE 1
carcinoembryonic antigen 1
LRP1 1
KRAS 1
beta-catenin 1
calmodulin 1 1
NaSi-1 1
p62 1
sex hormone-binding globulin 1
ROS 1
estrogen receptor alpha 1
ESR 1
estrogen receptor 1 1
BCL3 1
p16INK4a 1
transcobalamin I 1
TEL 1
ARF 1
inosine triphosphatase 1
FADH2 1
ELAM-1 1
Reduced folate carrier 1
NOS1 1
P100 1
endothelin-1 1
anonymous 1
NPPA 1
Leukocyte immunoglobulin-like receptor A3 1
CD28 1
dopamine D4 receptor 1
kinesin 1
GroES 1
tumour suppressor 1
HMP 1
PTPN6 1
E12 1
fatty acid synthase 1
IRS-1 1
IL-1 1
PGM 1
interleukin-10 1
ASC 1
choline acetylase 1
DAPK 1
CHL 1
COL18A1 1
N-acetyltransferase 1 1
L-asparaginase 1
AP2 1
metallothionein 1
Reduced Folate Carrier 1
tumor necrosis factor beta 1
GABRB3 1
DLK1 1
Wilson disease 1
TIMP3 1
HLA-G 1
JNK 1
pepsinogen A 1
mer 1
SP1 1
T-cadherin 1
phosphoenolpyruvate carboxykinase 1
lipoxygenase 1
EPAS1 1
cholesteryl ester transfer protein, plasma 1
NOS2 1
AAG 1
UGT1 1
AML1 1
CUBN 1
MyoD 1
GJA4 1
vascular endothelial growth factor A 1
aldose reductase 1
peptide transporter 1 1
segregation distortion 1
IL-8 1
IGF-1 1
WMS 1
AAA 1
DNA polymerase 1
Cad 1
DACT2 1
EPHX1 1
hepatocyte nuclear factor 1 alpha 1
arginine vasopressin 1
DNA repair enzyme 1
AT2 1
glycoprotein VI 1
FTCD 1
platelet collagen receptor 1
Breast Cancer Resistance Protein 1
N-acetyltransferase 2 1
alpha-2-macroglobulin 1
RAR 1
napsin A 1
T10 1
SOC 1
diaphorase 1
IL-2 1
c-kit 1
RARA 1
Glycerol kinase 1
glycerol kinase 1
multidrug resistance protein 1
Ins 1
CAPE 1
KIT 1
CDKN2B 1
CD320 1
ApoA-I 1
XPC 1
CYP2B6 1
TMN 1
nodal 1
osteocalcin 1
ERBB2 1
insulin-like growth factor 1
UMP synthase 1
LPS 1
Fibrinopeptide A 1
adenosyltransferase 1
anaplastic lymphoma kinase 1
CK7 1
ADRA1A 1
N-acetyltransferase 1
PEMT 1
SRO 1
MAP7 1
BHMT2 1
CTLA4 1
NAT1 1
Dnmt1 1
NIPA1 1
hOGG1 1
cystic fibrosis transmembrane conductance regulator 1
hGH 1
PLK1 1
aldehyde oxidase 1
leptin receptor 1
MAGEA1 1
antichymotrypsin 1
CYP2D6 1
CYP2A6 1
ERCC2 1
SRB 1
MRP2 1
ATP7B 1
Hsa 1
progesterone receptor 1
MINT2 1
lactase 1
Apo(a) 1
APBB1 1
Adiponectin 1
A-II 1
CTP:phosphocholine cytidylyltransferase 1
ICD 1
FAC 1
TNFRSF8 1
Tumor necrosis factor alpha 1
PAI1 1
polo-like kinase 1 1
nuclear receptor 1
tumor necrosis factor alpha 1
LEPR 1
ferritin 1
twist 1
PHA 1
NF1 1
asp 1
presenilin 2 1
SCD1 1
adenosine receptor 1
Apolipoprotein A-IV 1
RASSF1A 1
CD55 1
fat mass and obesity associated 1
NAD+ 1
thrombin receptor 1
UGT1A7 1
IGF2 1
PGF 1
proto-oncogene 1
divalent metal transporter 1 1
coagulation factor II 1
cysteine dioxygenase 1
DPYD 1
APOA5 1
CTH 1
adhesion molecule 1
leukemia inhibitory factor 1
dimethylglycine dehydrogenase 1
Myf-5 1
BRAF 1
D-serine 1
thrombin-activatable fibrinolysis inhibitor 1
5-HT2C 1
COL1A1 1
SNRPN 1
RANTES) 1
FIX 1
LEP 1
GNB3 1
P-selectin 1
TDT 1
CYP19 1
synapsin I 1
porphobilinogen synthase 1
CCR-5 1
N-acetylaspartate 1
heparin cofactor II 1
CED 1
ACTN3 1
catechol O-methyltransferase 1
A-1 1
MHC 1
Cytokine 1
CYP2E1 1
hemoglobin beta chain 1
alpha-adducin 1
PBS 1
KCNIP4 1
methylmalonyl-CoA mutase 1
MAO-A 1
beta 3-adrenergic receptor 1
alpha-1A-adrenergic receptor 1
NTP 1
GSD 1
glutathione S-transferase omega 1 1
type I protein C 1
NR1 1
TPH 1
CYP2C19 1
cryptic 1
lectin 1
SCA6 1
constitutive nitric oxide synthase 1
UDP glucuronosyltransferase 1
glucocorticoid receptor 1
SHMT2 1
MIM 1
Bot 1
IGS 1
alpha-1-antitrypsin 1
PDE5 1
AST 1
HOXB3 1
alpha 4 1
glucose-6-phosphate 1-dehydrogenase 1
CBFA2T3 1
Caldesmon 1
neurotrophic factor 1
vWF 1
Interleukin-16 1
guanine nucleotide binding protein 1
creatine transporter 1
AMH 1
PCK2 1
platelet-activating factor acetylhydrolase 1
histone 1
Neuropeptide W 1
exonuclease 1 1
sulfotransferase 1
GPR8 1
dopamine receptor D3 1
PRICKLE2 1
neurofibromatosis 1
AMN 1
leucine carboxyl methyltransferase 1
SAA1 1
CDC2 1
GART 1
GPIa 1
pyruvate carboxylase 1
gephyrin 1
transcriptional factor 1
UDP-glucuronosyltransferase 1A1 1
MOv18 1
MAX 1
folate binding protein 1
IBD 1
transmembrane protein 1
histone-lysine N-methyltransferase 1
UBE4B 1
guanidinoacetate methyltransferase 1
CCR4 1
macrophage migration inhibitory factor 1
ALPL 1
cblF 1
factor IX 1
GSK 1
ADORA2A 1
transforming growth factor beta 3 1
FSGS 1
10-formyltetrahydrofolate dehydrogenase 1
CYP17 1
Rec 1
FSAP 1
interferon gamma 1
lymphocyte antigen 1
SDS 1
IFNG 1
hENT1 1
MRP8 1
RASGRP1 1
CDK5 regulatory subunit associated protein 1 1
POLG 1
GCP2 1
urokinase plasminogen activator 1
DNA polymerase alpha 1
N-acetyltransferase-1 1
CYP7A1 1
erythroid 1
thyroid transcription factor-1 1
DCP1 1
FGB 1
CDX2 1
apolipoprotein A-I 1
sarcosine dehydrogenase 1
beta polypeptide 1
FTHFD 1
AS3 1
HLA-DRB1 1
intercellular adhesion molecule-1 1
tyrosine hydroxylase 1
nerve growth factor 1
insulin-like growth factor-I 1
TdT 1
HBB 1
plasma protein C 1
PTH 1
APOA1 1
cytokeratin 1
AMR 1
apolipoprotein A5 1
ribosomal protein S4 1
AKT 1
collagen type I alpha 1 1
LSM1 1
SMAD4 1
Beclin-1 1
A-T 1
SAH 1
ICAM1 1
CHD 1
A-I 1
NBS1 1
LCAT 1
NPB 1
FR-beta 1
cblD 1
non-functional 1
CYP2C9 1
BSS 1
SULT1A1 1
FAP 1
cage 1
sICAM-1 1
butyrylcholinesterase 1
Leukemia inhibitory factor 1
MLL 1
ALR2 1
intrinsic factor-vitamin B12 receptor 1
angiotensin I-converting enzyme 1
Cytosolic serine hydroxymethyltransferase 1
insulin receptor 1
AGTRAP 1
p15 1
presenilin 1 1
Disease
hyperhomocysteinemia 327
cancer 234
stroke 163
cardiovascular disease 125
atherosclerosis 92
vascular disease 92
coronary artery disease 85
hypertension 83
colorectal cancer 75
tumor 69
acute lymphoblastic leukemia 59
breast cancer 58
folate deficiency 58
diabetes 58
carcinogenesis 56
homocystinuria 54
schizophrenia 53
myocardial infarction 48
deep vein thrombosis 39
preeclampsia 38
Down syndrome 35
Alzheimer's disease 35
systemic lupus erythematosus 34
abortion 32
lymphoma 31
lupus 31
renal disease 30
lupus 30
obesity 27
childhood ALL 27
rheumatoid arthritis 25
dementia 25
migraine 24
pulmonary embolism 22
gastric cancer 22
leukemia 21
coronary heart disease 20
Thrombophilia 20
colon cancer 19
osteoporosis 19
cognitive impairment 18
male infertility 17
metabolic syndrome 17
vitamin B12 deficiency 17
type 2 diabetes 16
infertility 16
cleft palate 16
lung cancer 16
carcinoma 15
Parkinson's disease 15
acute myocardial infarction 14
adenoma 14
depression 14
malnutrition 14
epilepsy 14
sickle cell disease 14
heart disease 13
anemia 13
diabetic nephropathy 13
renal failure 13
essential hypertension 12
developmental delay 12
bipolar disorder 12
cerebral infarction 11
hepatocellular carcinoma 11
squamous cell carcinoma 10
tumorigenesis 10
megaloblastic anemia 10
adenocarcinoma 9
eclampsia 9
autism 9
psychosis 9
cirrhosis 9
arteriosclerosis 9
plaque 9
bladder cancer 8
rectal cancer 8
myocardial ischemia 8
fits 8
thrombocytopenia 8
antiphospholipid syndrome 8
cerebral ischemia 8
B-cell lymphoma 8
prostate cancer 8
retinopathy 8
transient ischemic attack 8
multiple myeloma 8
CBS deficiency 8
hemiparesis 8
azoospermia 8
genetic disorder 8
neutropenia 8
polycystic ovary syndrome 8
fatty liver 7
Factor V Leiden mutation 7
peripheral vascular disease 7
mental retardation 7
malabsorption 7
thalassemia 7
hypercholesterolemia 7
West 7
APC 7
abdominal aortic aneurysm 7
acute myeloid leukemia 7
mental illness 7
Ischemic stroke 7
inflammatory bowel disease 7
chronic renal failure 7
hyperlipidemia 7
mental retardation 7
ischemia 7
neurological disease 6
dyslipidemia 6
major depressive disorder 6
Budd-Chiari syndrome 6
diabetic retinopathy 6
multiple sclerosis 6
cervical intraepithelial neoplasia 6
Hodgkin's disease 6
ovarian cancer 6
memory impairment 6
coagulopathy 5
Autism 5
cardiovascular risk factor 5
leukoencephalopathy 5
adult ALL 5
childhood cancer 5
graft-versus-host disease 5
sensorineural hearing loss 5
peripheral neuropathy 5
neuropathy 5
Activated protein C resistance 5
follicular lymphoma 5
methylmalonic acidemia 5
chronic myeloid leukemia 5
esophageal cancer 5
oral cancer 5
type 1 diabetes 5
vasculitis 5
esophageal cancer 4
metabolic disorder 4
cervical cancer 4
renal impairment 4
proteinuria 4
heart failure 4
psoriasis 4
pancreatic cancer 4
chronic disease 4
hemolytic uremic syndrome 4
non-Hodgkin's lymphoma 4
chronic hepatitis 4
metastases 4
encephalopathy 4
non-small cell lung cancer 4
glaucoma 4
alcoholism 4
acute leukemia 4
abruptio placentae 4
venous stasis 4
leukopenia 4
lung carcinoma 3
cardiomyopathy 3
ATM 3
Best 3
glioblastoma multiforme 3
cerebral palsy 3
renal insufficiency 3
prematurity 3
movement disorder 3
endometrial cancer 3
oligospermia 3
Epstein 3
essential thrombocythemia 3
choline deficiency 3
cleft lip/palate 3
myelosuppression 3
sepsis 3
primary central nervous system lymphoma 3
hemoglobinopathies 3
LCP 3
Cerebral venous thrombosis 3
hepatitis 3
Perthes disease 3
ulcerative colitis 3
encephalomalacia 3
unipolar depression 3
hypertension in pregnancy 3
celiac disease 3
liver cancer 3
ischemic optic neuropathy 3
parkinsonism 3
nephrotic syndrome 3
Endothelial dysfunction 3
gangrene 3
liver cancer 3
liver fibrosis 3
hyperuricemia 3
riboflavin deficiency 3
hypovitaminosis 3
Crohn's disease 3
glioma 3
sepsis 3
Thrombus 3
failure to thrive 3
paraplegia 3
CIN II 3
methionine synthase deficiency 3
skin cancer 3
thyroid cancer 3
schizoaffective disorder 3
homocystinemia 3
Leukemia 3
myelopathy 3
amyotrophic lateral sclerosis 3
epithelial ovarian cancer 2
MCF 2
severe mental retardation 2
beta thalassemia 2
neurofibromatosis 2
postmenopausal bone loss 2
diplopia 2
polycythemia 2
membranous nephropathy 2
CIN I 2
enzyme deficiency 2
systemic disease 2
GSH 2
virus infection 2
MEST 2
hepatitis B 2
Esophageal squamous cell carcinoma 2
von Willebrand disease 2
blindness 2
arteriopathy 2
Ludwig 2
tuberculosis 2
hypogonadotropic hypogonadism 2
chronic lymphocytic leukemia 2
xeroderma pigmentosum 2
HPA 2
atrial septal defect 2
ventricular septal defect 2
Mycobacterium 2
cerebral thrombosis 2
Hepatotoxicity 2
myelodysplastic syndrome 2
Angelman syndrome 2
transitional cell carcinoma 2
autoimmune disease 2
RDA 2
hemochromatosis 2
amaurosis 2
psychiatric diagnosis 2
chronic lymphocytic leukemia 2
dysplasia 2
hematologic malignancies 2
lymphoproliferative disorders 2
PC deficiency 2
macular degeneration 2
CIN 2
hepatitis C 2
MMA 2
hemolytic anemia 2
Lynch syndrome 2
infectious diseases 2
Age-related macular degeneration 2
pulmonary hypertension 2
atrophic gastritis 2
Imerslund 2
neurofibromatosis type 1 2
HIV 2
mesenteric thrombosis 2
hypothyroidism 2
sarcoma 2
Poland 2
varices 2
primary myelofibrosis 2
Nonalcoholic fatty liver 2
HELLP syndrome 2
microalbuminuria 2
hemiplegic migraine 2
Deep vein thrombosis 2
arthritis 2
meningioma 2
chronic pain 2
cystic fibrosis 2
polycythemia vera 2
liver disease 2
unstable angina 2
Portal vein thrombosis 2
basal cell carcinoma 2
XPD 2
IVF 2
Placenta 2
Posterior 2
viral hepatitis 2
trisomy 2
malignant hypertension 1
scoliosis 1
optic atrophy 1
dental caries 1
Behcet's disease 1
PSS 1
scotoma 1
FRAXA 1
Acute mesenteric ischemia 1
vaccinia 1
HCA 1
renal cell carcinoma 1
hypogonadism 1
Pulmonary thromboembolism 1
hypopituitarism 1
osteoarthritis 1
APL 1
Brown 1
Bernard-Soulier syndrome 1
melanoma 1
perforated duodenal ulcer 1
HBB 1
AAA 1
leg ulcers 1
mitochondrial myopathy 1
psychological distress 1
ICD 1
human papilloma virus 1
Primary angle-closure glaucoma 1
Diabetic peripheral neuropathy 1
Acute encephalopathy 1
ileitis 1
venous disease 1
Autism spectrum disorder 1
Fabry 1
rare disease 1
glioblastoma 1
diabetic ketoacidosis 1
immunodeficiency 1
learning disability 1
diabetic neuropathy 1
short bowel syndrome 1
DVT 1
FHA 1
Peripheral arterial disease 1
Cholangiocarcinoma 1
optic nerve glioma 1
thalassemia major 1
brain edema 1
Infection 1
alcohol effect 1
chronic pancreatitis 1
hand-foot syndrome 1
fallopian tube 1
Williams syndrome 1
glomerulonephritis 1
Hepatocellular carcinoma 1
thrombocytosis 1
Tag 1
idiopathic disorder 1
Shiga 1
smallpox 1
acute renal failure 1
disseminated intravascular coagulation 1
immune deficiency 1
Focal segmental glomerulosclerosis 1
familial adenomatous polyposis 1
G6PD deficiency 1
MDS 1
Demented 1
Hereditary spastic paraplegia 1
neurogenic bladder 1
Lymphoblastic lymphoma 1
immaturity 1
eosinophilia 1
neoplastic transformation 1
HDL3 1
irritable bowel syndrome 1
ADHD 1
Central retinal artery occlusion 1
menstrual migraine 1
Shigella 1
NFLD 1
STEMI 1
Primary open-angle glaucoma 1
ankylosing spondylitis 1
dyskinesia 1
complicated pregnancy 1
alcoholic fatty liver 1
vitamin A deficiency 1
favism 1
vitamin B deficiency 1
abdominal obesity 1
gastroparesis 1
mild mental retardation 1
scalded skin syndrome 1
gout 1
subarachnoid hemorrhage 1
anaplastic large cell lymphoma 1
Congenital heart disease 1
ectopic pregnancy 1
Chronic infection 1
polyneuropathy 1
Esophageal adenocarcinoma 1
carcinomatosis 1
sensory disturbance 1
priapism 1
polyarteritis nodosa 1
macular edema 1
Graves' disease 1
cancer recurrence 1
hallucinations 1
protein deficiency 1
asthma 1
moyamoya 1
hamartoma 1
chronic obstructive pulmonary disease 1
trisomy 2 1
Wolfram syndrome 1
bone disease 1
developmental disabilities 1
papillary thyroid cancer 1
osteoporotic fracture 1
B-ALL 1
Lupus 1
HCG 1
Sjogren's syndrome 1
DBA 1
WMS 1
WMS 1
myopathy 1
MRT 1
worms 1
Lyme disease 1
Mycoplasma 1
fibromyalgia 1
myelitis 1
tumor progression 1
CIN 1 1
lymphoblastic leukemia 1
HNPCC 1
vitamin B6 deficiency 1
chorioamnionitis 1
Cholangiocarcinoma 1
Helicobacter pylori infection 1
myeloproliferative disorders 1
APL 1
APOA1 1
marginal zone lymphoma 1
peritonitis 1
Edwards 1
pancreatitis 1
brain tumor 1
chromosome disorder 1
AMN 1
arthropathy 1
glomerulosclerosis 1
sudden infant death syndrome 1
adult meningioma 1
Chimera 1
childhood NHL 1
NHL 1
EIA 1
Haemophilia 1
lymphoblastoma 1
secondary polycythemia 1
CTX 1
pancytopenia 1
Migraine with aura 1
HSP 1
TTP 1
pernicious anemia 1
Turner syndrome 1
chronic schizophrenia 1
SDS 1
leukemogenesis 1
bronchopulmonary dysplasia 1
premature labor 1
hypertensive retinopathy 1
fragile X syndrome 1
phenylketonuria 1
colitis 1
SEM 1
IMT 1
stomatitis 1
myeloid leukemia 1
stage IV NSCLC 1
colon neoplasm 1
bacterial vaginosis 1
Erdheim-Chester disease 1
phlebitis 1
renal artery stenosis 1
coma 1
anxiety disorders 1
malaria 1
Meningioma 1
cold 1
Placental infarction 1
head and neck cancer 1
erectile dysfunction 1
respiratory failure 1
confusion 1
Robin 1
addiction 1
bilateral breast cancer 1
Squamous Cell Carcinoma 1
Vascular dementia 1
Malignancy 1
portal hypertension 1
Retinal vein occlusion 1
interstitial nephritis 1
claudication 1
nephrosclerosis 1
laryngeal cancer 1
FFI 1
cystathioninuria 1
uremia 1
acute promyelocytic leukemia 1
minimal residual disease 1
Essential tremor 1
Left main coronary artery disease 1
cholesterolemia 1
aggressiveness 1
coprophagy 1
neuroblastoma 1
melancholia 1
Mesenteric infarction 1
Protein S deficiency 1
neurofibroma 1
iron deficiency 1
mammary tumor 1
cataract 1
HBB 1
Factor II mutation 1
TMN 1
maple syrup urine disease 1
adult T-cell leukemia/lymphoma 1
gastroenteritis 1
acute chest syndrome 1
human papilloma virus 1
diabetes insipidus 1
Meningioma 1
secondary amenorrhea 1
HBB 1
neuroticism 1
residual disease 1
aortic stenosis 1
Barrett's esophagus 1
invasive cervical cancer 1
Horner's syndrome 1
haemophilia 1
gastrointestinal disease 1
thalassemia minor 1
AIN 1
Marfan syndrome 1
PHA 1
Hashimoto's thyroiditis 1
carotid artery stenosis 1
chronic renal insufficiency 1
Bipolar II disorder 1
cognitive deficit 1
leukodystrophy 1
Gaucher disease 1
hydrocephalus 1
Cryptococcus neoformans 1
hydronephrosis 1
mastitis 1
pyoderma gangrenosum 1
Colon cancer 1
sarcoidosis 1
carpal tunnel syndrome 1
cerebral vasospasm 1
glucose intolerance 1
aphasia 1
FHM 1
epiphysis 1
B-cell lymphomas 1
sleep apnea 1
IgA nephropathy 1
HDL2 1
mental handicap 1
nystagmus 1
Dihydrofolate reductase deficiency 1
laryngeal cancer 1
morbid obesity 1
Krabbe disease 1
glutamate formiminotransferase deficiency 1
Familial hypercholesterolemia 1
habitual abortion 1
acute myocarditis 1
obsessive-compulsive disorder 1
tonsillitis 1
hyperinsulinemia 1
pyruvate kinase deficiency 1
cblF 1
cystitis 1
lactic acidosis 1
cytomegalovirus 1
solid tumor 1
gastrointestinal infection 1
deafness 1
oligodendroglioma 1
ARF 1
PLAT 1
unilateral blindness 1
Klinefelter's syndrome 1
Alcoholic liver disease 1
dehydration 1
iron deficiency anemia 1
Headache Disorders 1
gestational trophoblastic disease 1
paranoid schizophrenia 1
APL 1
HGF 1
Colorectal Cancer 1
aplastic anemia 1
status epilepticus 1
small cell lung cancer 1
arachnodactyly 1
pneumonia 1
senile dementia 1
Symptom
headache 18
seizures 15
overweight 10
pain 8
hypotonia 5
fatigue 5
ataxia 5
vomiting 5
abdominal pain 5
weakness 5
tremor 4
angina 4
nausea 4
spasm 3
paraparesis 3
spasticity 3
dysarthria 3
dyspnea 2
chest pain 2
numbness 2
cough 2
metamorphopsia 1
hemoptysis 1
anesthesia 1
hand pain 1
hypothermia 1
limb pain 1
photophobia 1
pallor 1
hepatomegaly 1
cachexia 1
hypertonia 1
paresis 1
stigma 1
anorexia 1
neck pain 1
cyanosis 1
lethargy 1
diarrhea 1
insomnia 1
photopsia 1
dizziness 1
memory loss 1
inanition 1
Decreased activity 1
hemiplegia 1
Livedoid 1
Drug
THF 26
FAD 15
Vitamin B12 15
Cardiovasc 10
NADH 10
pyridoxal phosphate 9
CSF 6
lysine 5
Vitamin B 5
Fragment 4
Monit 4
vitamin E 3
Nephron 3
ascorbate 3
Cobalamin 3
Dermatol 2
CTX 2
Bevacizumab 2
Hakka 2
Nephron 2
Folic Acid 2
CTX 1
CTA 1
DDAVP 1
Gemfibrozil 1
MDS 1
Asn 1
CTX 1
Indomethacin 1
Pyridoxal 1
GVG 1
TEL 1
niacin 1
Arsenic trioxide 1
Lamisil 1
IL-2 1
Fructose 1
DDAVP 1
TAC 1
Fluorescein 1
Deoxyadenosine 1
Ethanol 1
ICI 1
AZT 1
Amiloride 1
Pemetrexed 1
ENT 1
Oxaliplatin 1
Portal 1
Paraffin 1
Fluorescein 1
PTH 1
ROS 1
Leucovorin 1
Troglitazone 1
Riboflavin 1
Lamisil 1
Leaf 1
Simvastatin 1
AZT 1
Enzyme
methylenetetrahydrofolate reductase 2116
methylenetetrahydrofolate reductase 2116
methionine synthase 152
methionine synthase 147
methionine synthase reductase 89
thymidylate synthase 83
APC 80
cystathionine beta-synthase 63
methylenetetrahydrofolate dehydrogenase 33
methylenetetrahydrofolate dehydrogenase 26
dihydrofolate reductase 25
ACE 22
serine hydroxymethyltransferase 19
glutathione S-transferase 18
homocysteine methyltransferase 18
dihydropyrimidine dehydrogenase 17
cyclohydrolase 16
dihydropyrimidine dehydrogenase 15
methionine adenosyltransferase 14
formyltetrahydrofolate synthetase 13
thrombin 12
NQO1 9
thiopurine methyltransferase 8
aldehyde dehydrogenase 8
tissue plasminogen activator 7
ERK 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
betaine-homocysteine methyltransferase 6
aspartate aminotransferase 6
glutathione reductase 5
paraoxonase 5
paraoxonase 5
phosphatidylethanolamine N-methyltransferase 5
cystathionine gamma-synthase 5
calcineurin 5
DNA methyltransferase 4
superoxide dismutase 4
renin 4
cystathionine gamma-lyase 4
lipase 4
endonuclease 4
glycine N-methyltransferase 4
folylpolyglutamate synthetase 4
ATPase 4
thymidine phosphorylase 4
peroxidase 3
P-glycoprotein 3
conjugase 3
CAD 3
CAD 3
10-formyltetrahydrofolate dehydrogenase 3
cholesterol acyltransferase 3
proprotein convertase 3
subtilisin 3
carboxypeptidase G2 3
PTA 3
5,10-methenyltetrahydrofolate synthetase 3
glucose-6-phosphate dehydrogenase 3
choline dehydrogenase 3
diaphorase 3
focal adhesion kinase 3
UDP-glucuronosyltransferase 3
furin 3
AGT 3
methionyl-tRNA synthetase 3
prostate-specific membrane antigen 3
thromboplastin 3
asparaginase 3
alkaline phosphatase 3
CAD 3
alcohol dehydrogenase 3
lactate dehydrogenase 2
protein phosphatase 2A 2
lipoprotein lipase 2
dopamine beta-hydroxylase 2
lysozyme 2
catalase 2
glutathione peroxidase 2
alanine aminotransferase 2
creatine kinase 2
cathepsin D 2
protein kinase C 2
phosphodiesterase 2
phospholipase A2 2
glycinamide ribonucleotide transformylase 2
AICAR transformylase 2
lysyl oxidase 2
DNA polymerase 2
phosphoenolpyruvate carboxykinase 1
GSK 1
microsomal epoxide hydrolase 1
NADPH-diaphorase 1
kallikrein 1
TdT 1
GTP cyclohydrolase I 1
NOS 1
gamma-glutamyl transpeptidase 1
cholinesterase 1
trypsin 1
phosphoenolpyruvate carboxykinase 1
S-adenosylmethionine decarboxylase 1
lipoxygenase 1
acetate kinase 1
choline acetyltransferase 1
inosine triphosphatase 1
formylmethanofuran dehydrogenase 1
transcriptase 1
reverse transcriptase 1
homoserine transacetylase 1
lecithin:cholesterol acyltransferase 1
guanidinoacetate methyltransferase 1
heterodisulfide reductase 1
cysteine dioxygenase 1
formate dehydrogenase 1
lactase 1
jararhagin 1
glycerol kinase 1
luciferase 1
sucrase 1
choline kinase 1
pyruvate carboxylase 1
lactonase 1
RNA polymerase 1
beta-galactosidase 1
phenylalanine hydroxylase 1
PGM 1
flavin-containing monooxygenase 1
chaperonin 1
DNA ligase 1
AST 1
histone-lysine N-methyltransferase 1
invertase 1
phosphorylase 1
sarcosine dehydrogenase 1
AOR 1
caspase-3 1
nicotinamide N-methyltransferase 1
aldose reductase 1
dimethylglycine dehydrogenase 1
protein kinase 1
glucose-6-phosphatase 1
urokinase-type plasminogen activator 1
N-acetyltransferase 1
caffeoyl-CoA O-methyltransferase 1
methyl coenzyme M reductase 1
tryptophan hydroxylase 1
formate dehydrogenase 1
catechol O-methyltransferase 1
NO synthase 1
diaphorase 1
proteasome 1
LexA repressor 1
PRT 1
gamma-glutamylcysteine synthetase 1
CYP7A1 1
monoamine oxidase 1
polo-like kinase 1 1
CSAD 1
ADH3 1
delta-aminolevulinic acid dehydratase 1
S-adenosyl-L-homocysteine hydrolase 1
ribonucleotide reductase 1
formate dehydrogenase 1
bleomycin hydrolase 1
glycine decarboxylase 1
glutamate formiminotransferase 1
phosphoenolpyruvate carboxykinase 1
tyrosine hydroxylase 1
DNA ligase 1
fatty acid desaturase 1
thrombin-activatable fibrinolysis inhibitor 1
mitogen-activated protein kinase 1
aldehyde oxidase 1
Compound
homocysteine 780
DNA 337
methionine 241
Dec 164
Clin 160
PGA 127
Homocysteine 83
Homocysteine 83
adenosylmethionine 71
betaine 46
alanine 44
creatinine 37
valine 27
Cardiol 25
CBS 23
S-adenosylhomocysteine 22
glucose 21
water 21
cysteine 20
Methotrexate 20
serine 19
oxygen 18
FAD 16
His 14
NADPH 14
NADPH 14
nitric oxide 13
CH3-THF 12
calcium 12
Pac 12
sodium 11
phosphate 11
acetate 11
Methionine 10
glutamate 10
NADH 10
TMP 9
5,10-methenyltetrahydrofolate 9
urea 8
nicotinamide 8
5-FU 8
NAD 8
arginine 8
Choline 8
dUMP 8
folinic acid 8
NAD 7
vitamin D 7
ethanol 7
lysine 7
formaldehyde 7
hydrogen 7
5-formyltetrahydrofolate 7
formaldehyde 6
CO2 5
NADP 5
pyrimidine 5
leucine 5
ATP 5
sulfate 5
threonine 5
pyrimidine 5
nicotinic acid 5
aldosterone 4
Asp 4
Gly 4
tryptophan 4
tryptophan 4
Valproic acid 4
iron 4
H2S 4
uridine 4
Hemoglobin 4
dihydrofolate 4
tryptophan 4
tryptophan 4
Heparin 3
isoleucine 3
Cobalamin 3
Warfarin 3
zinc 3
dUTP 3
alcohol dehydrogenase 3
Ile 3
Cholesterol 3
PLP 3
PDT 3
DSM 3
EDTA 3
salt 3
MTX 3
Optimal 3
EDTA 3
Phe 3
MMA 3
nitrogen 3
H2S 3
THF 3
L-DOPA 3
isoleucine 3
aspartic acid 2
Azathioprine 2
Valproic acid 2
pentosidine 2
Formate 2
copper 2
dimethylarsinic acid 2
DMA 2
dimethylarsinic acid 2
TOF 2
Cystathionine 2
FMN 2
DMA 2
Angiotensin II 2
DBP 2
methane 2
MMA 2
dimethylarsinic acid 2
DBP 2
MMA 2
noradrenaline 2
dimethylarsinic acid 2
CTX 2
TNF 2
10-formyltetrahydrofolate 2
DMA 2
aspartic acid 2
tyrosine 2
Bantu 2
GSH 2
GSH 2
dimethylarsinic acid 2
aspartic acid 2
dimethylarsinic acid 2
nickel 2
proline 2
THF 2
5-HT 2
Ascorbic acid 2
benzene 2
ammonia 2
Abbott 2
hydroxyindoleacetic acid 2
Cystathionine 2
Insulin 2
glutamine 2
PMA 2
GABA 2
GABA 2
aspartic acid 2
Norepinephrine 1
selenium 1
MCP 1
glutamic acid 1
homoserine 1
gamma-aminobutyric acid 1
prostaglandin F2alpha 1
DMSO 1
C 10 1
CPA 1
Letter 1
retinol 1
ASC 1
SAH 1
Riboflavin 1
Genistein 1
Diabetol 1
Acyl-CoA 1
nicotinic acid 1
HCA 1
5,10-methylene-THF 1
N-acetylaspartate 1
PGE2 1
homoserine 1
Salt 1
NH2 1
Coenzyme Q10 1
retinoic acid 1
naphthoquinone 1
HBB 1
CPA 1
HCB 1
naphthoquinone 1
TBI 1
MTT 1
T 1 1
acetic acid 1
norvaline 1
Deoxyadenosine 1
SDS 1
butyric acid 1
Agarose 1
nicotinic acid 1
Thyroid 1
Arsenite 1
naphthoquinone 1
Valine 1
Paraquat 1
Diabetol 1
naphthoquinone 1
naphthoquinone 1
Tetrahydrocurcumin 1
vanadium 1
L-threonine 1
Uracil 1
H2O2 1
Glycine, 1
MDA 1
Glycine, 1
DEAE 1
TEL 1
TIB 1
EPC 1
butyric acid 1
ubiquinone 1
ADP 1
CPA 1
naphthoquinone 1
CoA 1
FAP 1
Benzene 1
TCN 1
Diamant 1
MSM 1
Creatine 1
butyric acid 1
Luminal 1
nicotinic acid 1
Estrogen 1
bromide 1
pteridine 1
Vitamin D 1
naphthoquinone 1
Pyridoxine 1
salicylic acid 1
Indomethacin 1
AZT 1
pyridine 1
A 42 1
neopterin 1
d4T 1
homoserine 1
Benazepril 1
Thiouracil 1
Pyridoxal 1
11-dehydro-thromboxane 1
AICAR 1
Estrogen 1
xylose 1
TDT 1
2-mercaptoethanol 1
Capecitabine 1
TBE 1
Sulfasalazine 1
Phosphatidylcholine 1
Purine 1
FAP 1
Menoctone 1
Lignin 1
Dopamine 1
C 10 1
Statin 1
ICI 1
PGE 1
Evans Blue 1
6-12 1
cAMP 1
Fructose 1
TTP 1
N2O 1
AAA 1
CoM 1
Parenteral 1
ASA 1
glycerol 1
asparagine 1
phosphoric acid 1
coenzyme Q10 1
Taurine 1
T10 1
CPA 1
5-hydroxytryptophan 1
acrylamide 1
toluene 1
ACh 1
norvaline 1
NMDA 1
Paraquat 1
phosphocreatine 1